Free Webinar: CRISPR screens decode human T cell function.

Genome engineering has the potential to revolutionize medicine, and Dr. Ralf Schmidt's work has been at the forefront of this transformation.

Join us in upcoming webinar as he describes the development of CRISPR screening platforms in primary human T cells, revealing key regulators of central T cell functions. This includes insights into cytokine production, surface marker regulation, and cytotoxic activity, all with potential therapeutic applications.

In detail, Dr. Schmidt has employed genome-wide CRISPR activation and CRISPR interference to map regulators of T cell cytokine production, identifying targets for cancer cell therapies. Furthermore, his use of base editing has increased screening resolution from the gene to the nucleotide level, identifying alleles that shape T cell functionality.

By projecting these mutations onto the two- and three-dimensional protein space, Dr. Schmidt has identified functional regions within genes, enabling the generation of allelic series to fine-tune T cell activity. Together, these studies aim to provide insights into genetic determinants of T cell functions and inform the design of next-generation genome therapies in T cells.

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Free Webinar: CRISPR screens decode human T cell function.

FREE WEBINAR! CRISPR screens decode human T cell function

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