Enhancing Treatments using Targeted Protein Degradation
Discover a webinar delving into targeted protein degradation (TPD), an approach using cellular machinery to selectively remove proteins, promising more effective treatments with minimized side effects. The classical small molecule drug discovery strategies are inhibiting the biological function of proteins of interest, which either block the active pocket or change the protein conformation. However, the significant disadvantages such as limitations in target candidates, dose issues and quick resistance foundations, are calling for a more preferable therapy with fewer side effects.
TPD, a strategy that utilizes the native protein homeostasis (or proteostasis) machinery to deplete proteins of interest (POI), represents a novel and promising therapeutic approach. Among them, ubiquitin-proteasomal degradation (UPD) is the most developed one. The core of UPD is bifunctional molecules, which can be small molecules, molecule chimeras or macromolecules, and harboring the ability to recognize and bind to both the target protein and the crucial components of ubiquitin ligase, by which the target protein is consequently specifically degraded. One bifunctional molecule can trigger multiple rounds of TPD.
Due to its advantages in low application dose and side effects, and the ability to make ‘undruggable’ druggable with less concern about direct activity inhibition, UPD drug development pipelines have increased dramatically in recent years for a variety of indications, including cancer, autoimmunity, neurodegeneration infections as well as agriculture.
To develop UPD drugs, both degrader components as well as target proteins are essential and are the start. Efficient and highly customized protein production will be a strong engine that can boost UPD drug discovery. GenScript has production experience on more than 200 ubiquitin ligase constructs and has provided thousands of high-quality target protein candidates.
Join this webinar to explore insights into TPD and learn new avenues for enhanced treatment efficacy through selective protein removal.
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