Adaptive Immune Response in Narcolepsy Type 1

Narcolepsy — a chronic neurological disorder — affects the brain’s capability in controlling the sleep-wake cycles. People affected with narcolepsy might feel rested after waking up, but then feel very sleepy throughout the day. Most people with narcolepsy also experience interrupted and uneven sleep that can involve waking up repeatedly during the night.

There are two main types of narcolepsy: type 1 and type 2. Narcolepsy type 1 (NT1) is based on the patient either having low levels of a brain hormone — hypocretin — or having excessive daytime sleepiness on a special nap test and reporting cataplexy (a brain disorder where there is a temporary and sudden loss of brain muscle tone and control).

People with narcolepsy type 2 experience extreme daytime sleepiness but usually don’t experience muscle weakness activated by emotions. These patients usually have lighter symptoms and normal levels of hypocretin.

Join this webinar to gain insights into an overview of adaptive immune response in narcolepsy. In this webinar, the featured speaker will discuss determining peptide binding affinity to human leukocyte antigen (HLA). The speaker will also share insights into isolating antigen-HLA-restricted CD4+ T cells using tetramer HLA. Attendees will also learn about single-cell RNA sequencing of CD4+ T cells and cerebrospinal fluid (CSF).

Join Dr. Guo Luo, Immunologist and Instructor, Stanford University School of Medicine, for the live webinar on Friday, October 6, 2023, at 1pm EDT (10am PDT).

Speaker-related Webinars

Adaptive Immune Response in Narcolepsy Type 1

Join this webinar to learn about the adaptive immune response in narcolepsy type 1 (NT1), including peptide binding affinity to human leukocyte antigen (HLA), the isolation of antigen-HLA restricted CD4+ T cells, and single-cell RNA sequencing of CD4+ T c

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