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Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex
Authors: Yang Yue, Chanjuan Xu, Lijie Wu, Man Na, Kexin Xu, Xuan Chen, Yuxuan Song, Sichun Weng, Lu Xu, Fei Li, Xi Lin, Arthur Wang, Jianfeng Liu, Fei Xu
Journal: Nature Communications
PubMed ID: 40790299
Doi: doi.org/10.1038/s41467-025-62870-z
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Optimised modular anti‐FLAG CAR T cells for solid tumor therapy
Authors: Xiaomeng Zhang, Rachel Xu, Dmitry Zorin, Evan G Pappas, Jiawei Tang, Yuchen Bai, Vicky M Qin, Bianca von Scheidt, Ruihong Huang, Weronika Kulakowska, Charbel Darido, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney
Journal: Clinical & Translational Immunology
PubMed ID: 40851786
Doi: 10.1002/cti2.70046
Products & Services: Recombinant Proteins   Gene Synthesis   
Structural basis for E4 enzyme Ufd2-catalyzed K48/K29 branched ubiquitin chains
Authors: Zebin Tong, Xiangwei Wu, Hongyi Cai, Shidian Wu, Tianyi Zhang, Zhiheng Deng, Ziyu Xu, Rujing Yuan, Huasong Ai, Lei Liu, Man Pan
Journal: Nature Chemical Biology
PubMed ID: 40817136
Doi: 10.1038/s41589-025-01985-2
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A Molecular Mechanism for the Reduction of the Cu Site in Lytic Polysaccharide Monooxygenases by Phenol Reductants
Authors: Langxing Liao, Jian Kuang, Peng Wu, Xianhang Sang, Heng Yin, Changlin Ti, Kingwang Zhang, Wei Peng, Lu Yu, Binju Wang
Journal: JACS Au
Doi: 10.1021/jacsau.5c00562
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The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation
Authors: Sydney S Skirboll, Medha Gangopadhyay, Han N Phan, Joshua Hartsell, Aditi Mudireddy, Dalton Hilovsky, Paul D Swartz, Xiaojing Liu, Yisong Guo, Thomas M Makris
Journal: Journal of the American Chemical Society
PubMed ID: 40774922
Doi: doi.org/10.1021/jacs.5c08814
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Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery
Authors: Elias Adriaenssens, Stefan Schaar, Annan S I Cook, Jan F M Stuke, Justyna Sawa-Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Louise Uoselis, Michael Lazarou, Gerhard Hummer, James H Hurley, Sascha Martens
Journal: Nature Cell Biology
PubMed ID: 40715440
Doi: 10.1038/s41556-025-01712-y
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Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain
Authors: Thales Hein Da Rosa, Sterling H Ramsey, Judy J Lee, Natalia Y Kozlova, Zixuan Zhao, Jaeyeon Kim, Ava C Schneider, Sheng Li, Madhusudhanarao Katiki, Gary S Firestein, Ramachandran Murali, Eugenio Santelli, Stephanie M Stanford, Nunzio Bottini
Journal: The Journal of Biological Chemistry
PubMed ID: 40651610
Doi: 10.1016/j.jbc.2025.110470
Optimization of Multiple Combinations of Early Secretion Pathways to Enhance Extracellular Protein Secretion in Komagataella phaffii
Authors: Hai Xu, Shijie Wang, Kang Li, Zhonghu Bai, Yankun Yang
Journal: Journal of Agricultural and Food Chemistry
PubMed ID: 40616507
Doi: doi.org/10.1021/acs.jafc.5c03402
Products & Services: Gene Synthesis   
CD19-ReTARGTPR: A Novel Fusion Protein for Physiological Engagement of Anti-CMV Cytotoxic T Cells Against CD19-Expressing Malignancies
Authors: Anne Paulien van Wijngaarden, Isabel Britsch, Matthias Peipp, Douwe Freerk Samplonius, Wijnand Helfrich
Journal: Cancers
PubMed ID: 40723184
Products & Services: Gene Synthesis   
A Carbamoyl N-Methyltransferase Catalyzes N-Methylation of the Primary Amide in Ansacarbamitocin Biosynthesis
Authors: Zhongyue Li, Wanting Yang, Zhonglin Sun, Haoxin Wang, Chunhua Lu, Deyu Zhu, Yuemao Shen
Journal: Journal of the American Chemical Society
PubMed ID: 40601550
Doi: 10.1021/jacs.5c05398
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