Gpr139 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr139
Entrez Gene ID	293545
Full Name	G protein-coupled receptor 139
General protein information	Preferred Names G protein-coupled receptor 139 Names probable G-protein coupled receptor 139 g(q)-coupled orphan receptor GPRg1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q35

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024241.1	NP_001019412.1	probable G-protein coupled receptor 139

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gpr139	NP_001019309.1
Rattus norvegicus (Norway rat)	Gpr139	NP_001019412.1
Macaca mulatta (Rhesus monkey)	GPR139	XP_001085003.1
Canis lupus familiaris (dog)	GPR139	XP_547108.3
Bos taurus (cattle)	GPR139	NP_001179694.1
Homo sapiens (human)	GPR139	NP_001002911.1
Gallus gallus (chicken)	GPR139	XP_428970.3
Pan troglodytes (chimpanzee)	GPR139	XP_001148556.1
Danio rerio (zebrafish)	LOC798482	XP_005163788.1
Xenopus tropicalis (tropical clawed frog)	gpr139	XP_002932269.1

Gene Ontology
Bibliography

Related articles in PubMed

Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.
Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O
eNeuro5(3)(2018 May-Jun)

GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine.
Liu C, Bonaventure P, Lee G, Nepomuceno D, Kuei C, Wu J, Li Q, Joseph V, Sutton SW, Eckert W, Yao X, Yieh L, Dvorak C, Carruthers N, Coate H, Yun S, Dugovic C, Harrington A, Lovenberg TW
Molecular pharmacology88(5)911-25(2015 Nov)

Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development.
Süsens U, Hermans-Borgmeyer I, Urny J, Schaller HC
Neuropharmacology50(4)512-20(2006 Mar)

Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system.
Matsuo A, Matsumoto S, Nagano M, Masumoto KH, Takasaki J, Matsumoto M, Kobori M, Katoh M, Shigeyoshi Y
Biochemical and biophysical research communications331(1)363-9(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gpr139 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr139 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06075	NM_001024241.1 Latest version!	Rattus norvegicus G protein-coupled receptor 139 (Gpr139), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr139 ( NM_001024241.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001019412.1 Rattus norvegicus G protein-coupled receptor 139 (Gpr139), mRNA.

Price & Availability↑

CloneID	ORa06075
Clone ID Related Accession (Same CDS sequence)	NM_001024241.1
Accession Version	NM_001024241.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550246400000
Organism	Rattus norvegicus(Norway rat)
Product	probable G-protein coupled receptor 139
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB196531.1. On May 27, 2005 this sequence version replaced XM_219399.3. ##Evidence-Data-START## Transcript exon combination :: AB196531.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCACA CGCACGCCCA CCTCGCTGCG AATAGCTCAG CTTGCGGCTT GGGCTTCGTG 
CCGGTGGTCT ACTACAGCTT CTTGTTGTGC CTCGGGTTAC CAGCAAATAT CTTGACAGTC 
ATCATCCTCT CTCAACTGGT AGCCAGAAGA CAGAAGTCCT CCTACAACTA TCTTCTGGCA 
CTTGCTGCTG CCGACATCTT GGTCCTCTTT TTCATCGTCT TTGTGGATTT CTTGTTAGAA 
GACTTCATTT TGACCATGCA GATGCCTCCG ATCCCTGACA AGATCATAGA AGTGCTAGAG 
TTCTCCTCCA TCCACACTTC TATTTGGATT ACAGTCCCCT TAACAGTTGA TAGGTATATC 
GCAGTCTGTC ACCCACTCAA ATACCACACA GTTTCCTACC CAGCCAGGAC CCGGAAAGTC 
ATTCTGAGTG TTTATATTAC CTGCTTCCTG ACTAGCATCC CCTACTACTG GTGGCCTAAC 
ATCTGGACTG AAGACTACAT CAGTACCTCC ATGCATCATG TCCTTGTCTG GATCCACTGC 
TTCACCGTGT ACCTGGTGCC CTGCTCCATC TTCTTCATCT TGAACTCAAT CATTGTGTAC 
AAGCTTAGGA GAAAGAGTAA TTTCCGCCTC CGTGGCTATT CCACTGGCAA GACCACTGCC 
ATCTTGTTTA CCATCACCTC CATCTTTGCT ACCCTCTGGG CCCCCCGCAT CATCATGATT 
CTCTACCACC TCTACGGAGC ACCCATCCAG AACCCTTGGC TGGTCCACAT TATGTTGGAT 
GTTGCCAACA TGCTGGCTCT TCTGAACACA GCCATCAACT TCTTCCTCTA CTGCTTCATC 
AGCAAGCGCT TCCGTACCAT GGCAGCTGCT ACACTCAAGG CCTTGTTCAA GTGCCAGAAG 
CAGCCTGTAC AGTTCTACAC CAACCATAAC TTTTCCATAA CAAGTAGTCC CTGGATCTCA 
CCAGCAAACT CACACTGCAT CAAAATGTTG GTGTACCAGT ATGACAAACA TGGGAAGCCT 
ATAAAAGTAT CCCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019412.1
CDS	1..1038
Translation	MEHTHAHLAANSSACGLGFVPVVYYSFLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILTMQMPPIPDKIIEVLEFSSIHTSIWITVPLTVDRYIAVCHPLKYHTVSYPARTRKVILSVYITCFLTSIPYYWWPNIWTEDYISTSMHHVLVWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNPWLVHIMLDVANMLALLNTAINFFLYCFISKRFRTMAAATLKALFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKHGKPIKVSP

Target ORF information:

RefSeq Version	NM_001024241.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor 139 (Gpr139), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024241.1

ORF Insert Sequence:

ATGGAGCACA CGCACGCCCA CCTCGCTGCG AATAGCTCAG CTTGCGGCTT GGGCTTCGTG 
CCGGTGGTCT ACTACAGCTT CTTGTTGTGC CTCGGGTTAC CAGCAAATAT CTTGACAGTC 
ATCATCCTCT CTCAACTGGT AGCCAGAAGA CAGAAGTCCT CCTACAACTA TCTTCTGGCA 
CTTGCTGCTG CCGACATCTT GGTCCTCTTT TTCATCGTCT TTGTGGATTT CTTGTTAGAA 
GACTTCATTT TGACCATGCA GATGCCTCCG ATCCCTGACA AGATCATAGA AGTGCTAGAG 
TTCTCCTCCA TCCACACTTC TATTTGGATT ACAGTCCCCT TAACAGTTGA TAGGTATATC 
GCAGTCTGTC ACCCACTCAA ATACCACACA GTTTCCTACC CAGCCAGGAC CCGGAAAGTC 
ATTCTGAGTG TTTATATTAC CTGCTTCCTG ACTAGCATCC CCTACTACTG GTGGCCTAAC 
ATCTGGACTG AAGACTACAT CAGTACCTCC ATGCATCATG TCCTTGTCTG GATCCACTGC 
TTCACCGTGT ACCTGGTGCC CTGCTCCATC TTCTTCATCT TGAACTCAAT CATTGTGTAC 
AAGCTTAGGA GAAAGAGTAA TTTCCGCCTC CGTGGCTATT CCACTGGCAA GACCACTGCC 
ATCTTGTTTA CCATCACCTC CATCTTTGCT ACCCTCTGGG CCCCCCGCAT CATCATGATT 
CTCTACCACC TCTACGGAGC ACCCATCCAG AACCCTTGGC TGGTCCACAT TATGTTGGAT 
GTTGCCAACA TGCTGGCTCT TCTGAACACA GCCATCAACT TCTTCCTCTA CTGCTTCATC 
AGCAAGCGCT TCCGTACCAT GGCAGCTGCT ACACTCAAGG CCTTGTTCAA GTGCCAGAAG 
CAGCCTGTAC AGTTCTACAC CAACCATAAC TTTTCCATAA CAAGTAGTCC CTGGATCTCA 
CCAGCAAACT CACACTGCAT CAAAATGTTG GTGTACCAGT ATGACAAACA TGGGAAGCCT 
ATAAAAGTAT CCCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.
eNeuro5(3)(2018 May-Jun)
Kononoff J,Kallupi M,Kimbrough A,Conlisk D,de Guglielmo G,George O

GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine.
Molecular pharmacology88(5)911-25(2015 Nov)
Liu C,Bonaventure P,Lee G,Nepomuceno D,Kuei C,Wu J,Li Q,Joseph V,Sutton SW,Eckert W,Yao X,Yieh L,Dvorak C,Carruthers N,Coate H,Yun S,Dugovic C,Harrington A,Lovenberg TW

Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development.
Neuropharmacology50(4)512-20(2006 Mar)
Süsens U,Hermans-Borgmeyer I,Urny J,Schaller HC

Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system.
Biochemical and biophysical research communications331(1)363-9(2005 May)
Matsuo A,Matsumoto S,Nagano M,Masumoto KH,Takasaki J,Matsumoto M,Kobori M,Katoh M,Shigeyoshi Y

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Gpr139 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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