Foxe3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Foxe3
Entrez Gene ID	171302
Full Name	forkhead box E3
Synonyms	FREAC-8,HFH7,HNF3
General protein information	Preferred Names forkhead box E3 Names forkhead box protein E3 forkhead-related protein FKHL12 forkhead-related transcription factor 8 hepatocyte nuclear factor 3 forkhead homolog 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q35
Summary	transcription factor responsible for tissue specific gene regulation and development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_134339.1	NP_599166.1	forkhead box protein E3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Foxe3	NP_056573.1
Bos taurus (cattle)	FOXE3	NP_001193251.1
Rattus norvegicus (Norway rat)	Foxe3	NP_599166.1
Gallus gallus (chicken)	FOXE3	XP_004936976.1
Canis lupus familiaris (dog)	FOXE3	XP_005629472.1

Gene Ontology
Bibliography

Related articles in PubMed

FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1.
Khan SY, Vasanth S, Kabir F, Gottsch JD, Khan AO, Chaerkady R, Lee MC, Leitch CC, Ma Z, Laux J, Villasmil R, Khan SN, Riazuddin S, Akram J, Cole RN, Talbot CC, Pourmand N, Zaghloul NA, Hejtmancik JF, Riazuddin SA
Nature communications710953(2016 04)

Functional analysis of FOXE3 mutations causing dominant and recessive ocular anterior segment disease.
Islam L, Kelberman D, Williamson L, Lewis N, Glindzicz MB, Nischal KK, Sowden JC
Human mutation36(3)296-300(2015 Mar)

Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3).
Wang Y, Li W, Wang Y, Huang Y
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie250(7)999-1007(2012 Jul)

Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage.
Blixt A, Landgren H, Johansson BR, Carlsson P
Developmental biology302(1)218-29(2007 Feb)

Homozygous nonsense mutation in the FOXE3 gene as a cause of congenital primary aphakia in humans.
Valleix S, Niel F, Nedelec B, Algros MP, Schwartz C, Delbosc B, Delpech M, Kantelip B
American journal of human genetics79(2)358-64(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Foxe3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Foxe3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00024	NM_134339.1 Latest version!	Rattus norvegicus forkhead box E3 (Foxe3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Foxe3 ( NM_134339.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_599166.1 Rattus norvegicus forkhead box E3 (Foxe3), mRNA.

Price & Availability↑

CloneID	ORa00024
Clone ID Related Accession (Same CDS sequence)	NM_134339.1
Accession Version	NM_134339.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576771200000
Organism	Rattus norvegicus(Norway rat)
Product	forkhead box protein E3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07049695.1. On or before Apr 6, 2013 this sequence version replaced XM_233428.2, XM_001069443.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignment of transcripts and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END##

ATGGATGCGC ACGTCGCTTT CTCCGGCTTT CCGACCCTGC CCTCGGTCTC GCCGTCGGGG 
CCGCAGCCTC CATCGCTGGC CGGAGACGAG CCCGGGCGCG AACCAGAGGA GGTGGTGGGC 
GGTGGGGACT CCGAGCCCCC GGCCGCGCCG GGCCCTGGGA GGCGACGTCG GCGGCCGCTA 
CAGCGTGGGA AGCCGCCTTA CTCGTACATC GCTCTTATCG CTATGGCCCT GGCGCACGCT 
CCGGGCCGTC GTCTCACGCT GGCAGCCATC TACCGCTTCA TCACCGAGCG CTTCGCCTTC 
TACCGCGACA GCCCGCGCAA GTGGCAGAAC AGCATCCGCC ACAACCTCAC CCTCAACGAC 
TGCTTCGTCA AGGTGCCGCG CGAGCCGGGC AATCCGGGCA AGGGCAACTA CTGGACGCTC 
GATCCCGCGG CCGCCGACAT GTTCGACAAC GGCAGCTTCC TGCGGCGCCG CAAGCGCTTT 
AAGCGCACCG AGCTGCCCGC GCCGCCGCCA CCGCCCTTTC CCTACGCGCC CTTCCCGCCC 
GCACCTGCAC CTGCGCCCGC ACCGCCCGCG CGCCTCTTCC GCCTGGACAG CCTGCTGGGC 
TTGCAAACCG AGCCGCCAGG ACCCTTGGCG CCCGAGCCGC CTTGCTGCGC CGCGCCCGAC 
GCCTCCTTCC CGCCCTGCGC CGCCGCAGCC TCGCCGCCGC TCTACTCGCC CGCGCCCGAG 
CGCCTGGGGC TGCCCGCGCC GTTGCCGGCG GAGCCTCTCC TGGCCTTGGC AGGATCGGCT 
GGCGCGCTGG GGCCACTCGG CGCCGGAGAA GCCTACCTGA GACAGCCGGG CTTCCCGCCC 
GGGCTGGAGC GCTACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599166.1
CDS	1..861
Translation	MDAHVAFSGFPTLPSVSPSGPQPPSLAGDEPGREPEEVVGGGDSEPPAAPGPGRRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRKRFKRTELPAPPPPPFPYAPFPPAPAPAPAPPARLFRLDSLLGLQTEPPGPLAPEPPCCAAPDASFPPCAAAASPPLYSPAPERLGLPAPLPAEPLLALAGSAGALGPLGAGEAYLRQPGFPPGLERYL

Target ORF information:

RefSeq Version	NM_134339.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus forkhead box E3 (Foxe3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134339.1

ORF Insert Sequence:

ATGGATGCGC ACGTCGCTTT CTCCGGCTTT CCGACCCTGC CCTCGGTCTC GCCGTCGGGG 
CCGCAGCCTC CATCGCTGGC CGGAGACGAG CCCGGGCGCG AACCAGAGGA GGTGGTGGGC 
GGTGGGGACT CCGAGCCCCC GGCCGCGCCG GGCCCTGGGA GGCGACGTCG GCGGCCGCTA 
CAGCGTGGGA AGCCGCCTTA CTCGTACATC GCTCTTATCG CTATGGCCCT GGCGCACGCT 
CCGGGCCGTC GTCTCACGCT GGCAGCCATC TACCGCTTCA TCACCGAGCG CTTCGCCTTC 
TACCGCGACA GCCCGCGCAA GTGGCAGAAC AGCATCCGCC ACAACCTCAC CCTCAACGAC 
TGCTTCGTCA AGGTGCCGCG CGAGCCGGGC AATCCGGGCA AGGGCAACTA CTGGACGCTC 
GATCCCGCGG CCGCCGACAT GTTCGACAAC GGCAGCTTCC TGCGGCGCCG CAAGCGCTTT 
AAGCGCACCG AGCTGCCCGC GCCGCCGCCA CCGCCCTTTC CCTACGCGCC CTTCCCGCCC 
GCACCTGCAC CTGCGCCCGC ACCGCCCGCG CGCCTCTTCC GCCTGGACAG CCTGCTGGGC 
TTGCAAACCG AGCCGCCAGG ACCCTTGGCG CCCGAGCCGC CTTGCTGCGC CGCGCCCGAC 
GCCTCCTTCC CGCCCTGCGC CGCCGCAGCC TCGCCGCCGC TCTACTCGCC CGCGCCCGAG 
CGCCTGGGGC TGCCCGCGCC GTTGCCGGCG GAGCCTCTCC TGGCCTTGGC AGGATCGGCT 
GGCGCGCTGG GGCCACTCGG CGCCGGAGAA GCCTACCTGA GACAGCCGGG CTTCCCGCCC 
GGGCTGGAGC GCTACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1.
Nature communications710953(2016 04)
Khan SY,Vasanth S,Kabir F,Gottsch JD,Khan AO,Chaerkady R,Lee MC,Leitch CC,Ma Z,Laux J,Villasmil R,Khan SN,Riazuddin S,Akram J,Cole RN,Talbot CC,Pourmand N,Zaghloul NA,Hejtmancik JF,Riazuddin SA

Functional analysis of FOXE3 mutations causing dominant and recessive ocular anterior segment disease.
Human mutation36(3)296-300(2015 Mar)
Islam L,Kelberman D,Williamson L,Lewis N,Glindzicz MB,Nischal KK,Sowden JC

Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3).
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie250(7)999-1007(2012 Jul)
Wang Y,Li W,Wang Y,Huang Y

Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage.
Developmental biology302(1)218-29(2007 Feb)
Blixt A,Landgren H,Johansson BR,Carlsson P

Homozygous nonsense mutation in the FOXE3 gene as a cause of congenital primary aphakia in humans.
American journal of human genetics79(2)358-64(2006 Aug)
Valleix S,Niel F,Nedelec B,Algros MP,Schwartz C,Delbosc B,Delpech M,Kantelip B

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Foxe3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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