Mark1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mark1
Entrez Gene ID	117016
Full Name	microtubule affinity regulating kinase 1
General protein information	Preferred Names microtubule affinity regulating kinase 1 Names serine/threonine-protein kinase MARK1 MAP/microtubule affinity-regulating kinase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q26
Summary	phosphorylates the microtubule binding domain of microtubule-associated proteins and facilitates microtubule disruption; plays a role in microtubule dynamics [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008769816.2	XP_008768038.1	serine/threonine-protein kinase MARK1 isoform X1
NM_053947.1	NP_446399.1	serine/threonine-protein kinase MARK1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MARK1	NP_001179204.2
Rattus norvegicus (Norway rat)	Mark1	NP_446399.1
Gallus gallus (chicken)	MARK1	XP_004935368.1
Xenopus tropicalis (tropical clawed frog)	mark1	XP_002936069.2
Macaca mulatta (Rhesus monkey)	LOC710695	XP_002808296.1
Mus musculus (house mouse)	Mark1	NP_663490.2
Homo sapiens (human)	MARK1	NP_061120.3
Pan troglodytes (chimpanzee)	MARK1	XP_001172839.2
Canis lupus familiaris (dog)	MARK1	XP_005640992.1
Danio rerio (zebrafish)	mark1	NP_001107948.1

Gene Ontology
Bibliography

Related articles in PubMed

MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
Bernard LP, Zhang H
PloS one10(5)e0124816(2015)

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.
Gu GJ, Lund H, Wu D, Blokzijl A, Classon C, von Euler G, Landegren U, Sunnemark D, Kamali-Moghaddam M
Neuromolecular medicine15(3)458-69(2013 Sep)

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.
Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA
Cell143(6)966-77(2010 Dec)

Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.
Maussion G, Carayol J, Lepagnol-Bestel AM, Tores F, Loe-Mie Y, Milbreta U, Rousseau F, Fontaine K, Renaud J, Moalic JM, Philippi A, Chedotal A, Gorwood P, Ramoz N, Hager J, Simonneau M
Human molecular genetics17(16)2541-51(2008 Aug)

Microtubule affinity-regulating kinase 1 (MARK1) is activated by electroconvulsive shock in the rat hippocampus.
Jeon S, Kim YS, Park J, Bae CD
Journal of neurochemistry95(6)1608-18(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mark1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mark1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11140	NM_053947.1 Latest version!	Rattus norvegicus microtubule affinity regulating kinase 1 (Mark1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
ORa44079	XM_008769816.2 Latest version!	Rattus norvegicus microtubule affinity regulating kinase 1 (Mark1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mark1 ( NM_053947.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446399.1 Rattus norvegicus microtubule affinity regulating kinase 1 (Mark1), mRNA.

Price & Availability↑

CloneID	ORa11140
Clone ID Related Accession (Same CDS sequence)	NM_053947.1
Accession Version	NM_053947.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569168000000
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase MARK1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z83868.1. ##Evidence-Data-START## Transcript exon combination :: Z83868.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCGGCGC GGACGCCATT GCCCACGGTG AACGAGCGGG ACACGGAGAA CCATACATCT 
GTGGATGGAT ATACTGAAAC GCATATCCCG CCTACCAAAT CAAGTAGCAG ACAAAACATT 
CCCCGGTGTA GAAACTCCAT TACGTCAGCG ACAGATGAAC AGCCTCACAT CGGAAATTAC 
CGTTTACAGA AAACAATAGG GAAGGGGAAT TTTGCCAAAG TGAAATTGGC AAGGCATGTC 
CTAACAGGTA GAGAGGTAGC TGTGAAAATA ATAGACAAAA CTCAGCTAAA CCCTACCAGT 
CTACAAAAGT TGTTCCGAGA AGTACGAATA ATGAAGATAC TGAACCATCC TAACATAGTG 
AAACTGTTTG AAGTTATTGA AACAGAGAAG ACGCTCTACC TGGTCATGGA ATACGCAAGT 
GGGGGTGAAG TCTTTGATTA CTTAGTTGCC CACGGAAGAA TGAAAGAGAA AGAGGCCCGG 
GCCAAATTCA GGCAGATTGT ATCTGCTGTA CAGTATTGTC ATCAAAAATG CATTGTCCAC 
CGTGATCTTA AGGCTGAAAA CCTTCTCCTT GATGCTGATA TGAATATTAA AATTGCTGAC 
TTTGGTTTTA GCAATGAATT CACAGTGGGG AACAAATTGG ACACATTCTG TGGAAGCCCG 
CCTTATGCTG CCCCTGAGCT TTTCCAAGGC AAGAAGTACG ACGGGCCGGA AGTGGATGTG 
TGGAGTCTAG GCGTCATTCT CTACACGCTG GTCAGTGGCT CCCTGCCTTT CGATGGCCAG 
AATCTAAAGG AGCTCCGGGA GCGGGTCCTG CGAGGGAAGT ACCGTGTTCC TTTCTACATG 
TCCACGGACT GCGAGAACCT CCTGAAGAAA CTGCTAGTGC TGAACCCCAT AAAGAGGGGC 
AGCCTGGAGC AAATAATGAA AGACCGATGG ATGAACGTTG GTCATGAAGA GGAAGAGCTA 
AAACCATATT CTGAGCCTGA GCTTGATCTC AATGATGCAA AAAGAATAGA CATTATGGTC 
ACCATGGGTT TTGCACGAGA TGAAATCAAT GATGCCTTAG TAAGCCAGAA ATATGATGAG 
GTTATGGCTA CTTATATTCT TCTAGGTAGA AAACCACCTG AGTTCGAAGG TGGTGAGTCA 
CTGTCCAGTG GAAACCTTTG TCAGCGATCC CGGCCGAGCA GTGACCTGAA CAACAGCACG 
CTTCAGTCAC CTGCTCACCT GAAGGTCCAG CGAAGCATCT CAGCCAACCA GAAGCAGAGG 
CGCTTCAGTG ACCATGCCGG TCCCTCCATC CCCCCTGCTG TCTCATACAC CAAAAGGCCT 
CAGGCCAACA GCGTGGAGAG TGAACAGAAA GAGGAGTGGG ACAAAGACAC AGCCCGCAGA 
CTTGGCAGCA CCACCGTGGG CTCGAAGAGC GAAGTCACAG CCAGCCCCTT GGTGGGGCCA 
GACAGGAAAA AGTCCTCAGC TGGCCCAAGT AACAACGTAT ATTCTGGCGG TAGCATGACG 
AGGAGAAATA CATATGTGTG TGAGAGGAGC ACGGACCGGT ACGCTGCCTT GCAGAATGGA 
AGAGACAGCA GCCTTACAGA GATGTCTGCC AGCAGCATGT CCTCCACAGG TTCCACTGTG 
GCCTCTGCTG GCCCCTCAGC ACGTCCCCGC CACCAGAAGT CTATGTCAAC CTCTGGCCAC 
CCTATTAAAG TTACACTGCC AACCATTAAA GATGGCTCTG AAGCTTATCG GCCTGGTACA 
GCTCAGAGAG TGCCTGCTGC TTCCCCGTCT GCTCACAGCA TTAGTGCCAG TACTCCTGAC 
AGGACCCGCT TCCCCCGAGG GAGCTCCAGC CGAAGCACTT TCCACGGGGA GCAGCTCCGA 
GAGCGGCGCA GTGCTGCTTA TAGCGGACCA CCTGCCTCCC CGTCCCATGA CACAGCTGCA 
CTTGCACATG CCAGAAGGGG GACGTCAACT GGGATAATCA GCAAAATCAC CTCCAAGTTC 
GTCCGCAGGG ACCCAAGTGA AGGCGAAGCC AGTGGCAGAA CCGACACAGC CAGAGGTTCA 
TCGGGGGAGC CGAAAGACAA GGAAGAGGGT AAGGAGGCCA AGCCGAGGTC GCTGCGCTTC 
ACGTGGAGCA TGAAGACCAC TAGTTCAATG GACCCCAATG ACATGGTGAG AGAGATCCGC 
AAGGTGCTGG ATGCCAACAC CTGTGACTAT GAACAGAGAG AGAGGTTCCT GCTCTTCTGC 
GTTCACGGAG ACGCTCGGCA GGACAGCCTC GTACAGTGGG AGATGGAGGT CTGCAAGTTG 
CCTCGGCTCT CACTCAATGG GGTCCGCTTC AAGCGAATAT CCGGGACATC TATTGCCTTT 
AAGAACATTG CATCCAAAAT AGCAAATGAG CTTAAGCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446399.1
CDS	153..2534
Translation	MSARTPLPTVNERDTENHTSVDGYTETHIPPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDLNDAKRIDIMVTMGFARDEINDALVSQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDTARRLGSTTVGSKSEVTASPLVGPDRKKSSAGPSNNVYSGGSMTRRNTYVCERSTDRYAALQNGRDSSLTEMSASSMSSTGSTVASAGPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTAQRVPAASPSAHSISASTPDRTRFPRGSSSRSTFHGEQLRERRSAAYSGPPASPSHDTAALAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTARGSSGEPKDKEEGKEAKPRSLRFTWSMKTTSSMDPNDMVREIRKVLDANTCDYEQRERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL

Target ORF information:

RefSeq Version	NM_053947.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus microtubule affinity regulating kinase 1 (Mark1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053947.1

ORF Insert Sequence:

ATGTCGGCGC GGACGCCATT GCCCACGGTG AACGAGCGGG ACACGGAGAA CCATACATCT 
GTGGATGGAT ATACTGAAAC GCATATCCCG CCTACCAAAT CAAGTAGCAG ACAAAACATT 
CCCCGGTGTA GAAACTCCAT TACGTCAGCG ACAGATGAAC AGCCTCACAT CGGAAATTAC 
CGTTTACAGA AAACAATAGG GAAGGGGAAT TTTGCCAAAG TGAAATTGGC AAGGCATGTC 
CTAACAGGTA GAGAGGTAGC TGTGAAAATA ATAGACAAAA CTCAGCTAAA CCCTACCAGT 
CTACAAAAGT TGTTCCGAGA AGTACGAATA ATGAAGATAC TGAACCATCC TAACATAGTG 
AAACTGTTTG AAGTTATTGA AACAGAGAAG ACGCTCTACC TGGTCATGGA ATACGCAAGT 
GGGGGTGAAG TCTTTGATTA CTTAGTTGCC CACGGAAGAA TGAAAGAGAA AGAGGCCCGG 
GCCAAATTCA GGCAGATTGT ATCTGCTGTA CAGTATTGTC ATCAAAAATG CATTGTCCAC 
CGTGATCTTA AGGCTGAAAA CCTTCTCCTT GATGCTGATA TGAATATTAA AATTGCTGAC 
TTTGGTTTTA GCAATGAATT CACAGTGGGG AACAAATTGG ACACATTCTG TGGAAGCCCG 
CCTTATGCTG CCCCTGAGCT TTTCCAAGGC AAGAAGTACG ACGGGCCGGA AGTGGATGTG 
TGGAGTCTAG GCGTCATTCT CTACACGCTG GTCAGTGGCT CCCTGCCTTT CGATGGCCAG 
AATCTAAAGG AGCTCCGGGA GCGGGTCCTG CGAGGGAAGT ACCGTGTTCC TTTCTACATG 
TCCACGGACT GCGAGAACCT CCTGAAGAAA CTGCTAGTGC TGAACCCCAT AAAGAGGGGC 
AGCCTGGAGC AAATAATGAA AGACCGATGG ATGAACGTTG GTCATGAAGA GGAAGAGCTA 
AAACCATATT CTGAGCCTGA GCTTGATCTC AATGATGCAA AAAGAATAGA CATTATGGTC 
ACCATGGGTT TTGCACGAGA TGAAATCAAT GATGCCTTAG TAAGCCAGAA ATATGATGAG 
GTTATGGCTA CTTATATTCT TCTAGGTAGA AAACCACCTG AGTTCGAAGG TGGTGAGTCA 
CTGTCCAGTG GAAACCTTTG TCAGCGATCC CGGCCGAGCA GTGACCTGAA CAACAGCACG 
CTTCAGTCAC CTGCTCACCT GAAGGTCCAG CGAAGCATCT CAGCCAACCA GAAGCAGAGG 
CGCTTCAGTG ACCATGCCGG TCCCTCCATC CCCCCTGCTG TCTCATACAC CAAAAGGCCT 
CAGGCCAACA GCGTGGAGAG TGAACAGAAA GAGGAGTGGG ACAAAGACAC AGCCCGCAGA 
CTTGGCAGCA CCACCGTGGG CTCGAAGAGC GAAGTCACAG CCAGCCCCTT GGTGGGGCCA 
GACAGGAAAA AGTCCTCAGC TGGCCCAAGT AACAACGTAT ATTCTGGCGG TAGCATGACG 
AGGAGAAATA CATATGTGTG TGAGAGGAGC ACGGACCGGT ACGCTGCCTT GCAGAATGGA 
AGAGACAGCA GCCTTACAGA GATGTCTGCC AGCAGCATGT CCTCCACAGG TTCCACTGTG 
GCCTCTGCTG GCCCCTCAGC ACGTCCCCGC CACCAGAAGT CTATGTCAAC CTCTGGCCAC 
CCTATTAAAG TTACACTGCC AACCATTAAA GATGGCTCTG AAGCTTATCG GCCTGGTACA 
GCTCAGAGAG TGCCTGCTGC TTCCCCGTCT GCTCACAGCA TTAGTGCCAG TACTCCTGAC 
AGGACCCGCT TCCCCCGAGG GAGCTCCAGC CGAAGCACTT TCCACGGGGA GCAGCTCCGA 
GAGCGGCGCA GTGCTGCTTA TAGCGGACCA CCTGCCTCCC CGTCCCATGA CACAGCTGCA 
CTTGCACATG CCAGAAGGGG GACGTCAACT GGGATAATCA GCAAAATCAC CTCCAAGTTC 
GTCCGCAGGG ACCCAAGTGA AGGCGAAGCC AGTGGCAGAA CCGACACAGC CAGAGGTTCA 
TCGGGGGAGC CGAAAGACAA GGAAGAGGGT AAGGAGGCCA AGCCGAGGTC GCTGCGCTTC 
ACGTGGAGCA TGAAGACCAC TAGTTCAATG GACCCCAATG ACATGGTGAG AGAGATCCGC 
AAGGTGCTGG ATGCCAACAC CTGTGACTAT GAACAGAGAG AGAGGTTCCT GCTCTTCTGC 
GTTCACGGAG ACGCTCGGCA GGACAGCCTC GTACAGTGGG AGATGGAGGT CTGCAAGTTG 
CCTCGGCTCT CACTCAATGG GGTCCGCTTC AAGCGAATAT CCGGGACATC TATTGCCTTT 
AAGAACATTG CATCCAAAAT AGCAAATGAG CTTAAGCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mark1 ( XM_008769816.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008768038.1 Rattus norvegicus microtubule affinity regulating kinase 1 (Mark1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa44079
Clone ID Related Accession (Same CDS sequence)	XM_008769816.2
Accession Version	XM_008769816.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2541bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase MARK1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008769816.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 6% of CDS bases ##RefSeq-Attributes-END##

ATGGCAGTTC CTAACATGGA ACAAAGAATC CCTTCAGCGA GAAGTGAATC AGTGCAACAC 
TCGAGTGATG TAAAGAAGAC CTGCAAAGAT GATGAGGGAA ACGCTTTAGA AATAAGAGAA 
GGGCGTGAAT ACCAGTGCCT GGTTAACGAT CATTTGAAAG GCAGAGCGGA CGCATTGCCC 
ACGGTGAACG AGCGGGACAC GGAGAACCAT ACATCTGTGG ATGGATATAC TGAAACGCAT 
ATCCCGCCTA CCAAATCAAG TAGCAGACAA AACATTCCCC GGTGTAGAAA CTCCATTACG 
TCAGCGACAG ATGAACAGCC TCACATCGGA AATTACCGTT TACAGAAAAC AATAGGGAAG 
GGGAATTTTG CCAAAGTGAA ATTGGCAAGG CATGTCCTAA CAGGTAGAGA GGTAGCTGTG 
AAAATAATAG ACAAAACTCA GCTAAACCCT ACCAGTCTAC AAAAGTTGTT CCGAGAAGTA 
CGAATAATGA AGATACTGAA CCATCCTAAC ATAGTGAAAC TGTTTGAAGT TATTGAAACA 
GAGAAGACGC TCTACCTGGT CATGGAATAC GCAAGTGGGG GTGAAGTCTT TGATTACTTA 
GTTGCCCACG GAAGAATGAA AGAGAAAGAG GCCCGGGCCA AATTCAGGCA GATTGTATCT 
GCTGTACAGT ATTGTCATCA AAAATGCATT GTCCACCGTG ATCTTAAGGC TGAAAACCTT 
CTCCTTGATG CTGATATGAA TATTAAAATT GCTGACTTTG GTTTTAGCAA TGAATTCACA 
GTGGGGAACA AATTGGACAC ATTCTGTGGA AGCCCGCCTT ATGCTGCCCC TGAGCTTTTC 
CAAGGCAAGA AGTACGACGG GCCGGAAGTG GATGTGTGGA GTCTAGGCGT CATTCTCTAC 
ACGCTGGTCA GTGGCTCCCT GCCTTTCGAT GGCCAGAATC TAAAGGAGCT CCGGGAGCGG 
GTCCTGCGAG GGAAGTACCG TGTTCCTTTC TACATGTCCA CGGACTGCGA GAACCTCCTG 
AAGAAACTGC TAGTGCTGAA CCCCATAAAG AGGGGCAGCC TGGAGCAAAT AATGAAAGAC 
CGATGGATGA ACGTTGGTCA TGAAGAGGAA GAGCTAAAAC CATATTCTGA GCCTGAGCTT 
GATCTCAATG ATGCAAAAAG AATAGACATT ATGGTCACCA TGGGTTTTGC ACGAGATGAA 
ATCAATGATG CCTTAGTAAG CCAGAAATAT GATGAGGTTA TGGCTACTTA TATTCTTCTA 
GGTAGAAAAC CACCTGAGTT CGAAGGTGGT GAGTCACTGT CCAGTGGAAA CCTTTGTCAG 
CGATCCCGGC CGAGCAGTGA CCTGAACAAC AGCACGCTTC AGTCACCTGC TCACCTGAAG 
GTCCAGCGAA GCATCTCAGC CAACCAGAAG CAGAGGCGCT TCAGTGACCA TGCCGGTCCC 
TCCATCCCCC CTGCTGTCTC ATACACCAAA AGGCCTCAGG CCAACAGCGT GGAGAGTGAA 
CAGAAAGAGG AGTGGGACAA AGACACAGCC CGCAGACTTG GCAGCACCAC CGTGGGCTCG 
AAGAGCGAAG TCACAGCCAG CCCCTTGGTG GGGCCAGACA GGAAAAAGTC CTCAGCTGGC 
CCAAGTAACA ACGTATATTC TGGCGGTAGC ATGACGAGGA GAAATACATA TGTGTGTGAG 
AGGAGCACGG ACCGGTACGC TGCCTTGCAG AATGGAAGAG ACAGCAGCCT TACAGAGATG 
TCTGCCAGCA GCATGTCCTC CACAGGTTCC ACTGTGGCCT CTGCTGGCCC CTCAGCACGT 
CCCCGCCACC AGAAGTCTAT GTCAACCTCT GGCCACCCTA TTAAAGTTAC ACTGCCAACC 
ATTAAAGATG GCTCTGAAGC TTATCGGCCT GGCAGTACAG CTCAGAGAGT GCCTGCTGCT 
TCCCCGTCTG CTCACAGCAT TAGTGCCAGT ACTCCTGACA GGACCCGCTT CCCCCGAGGG 
AGCTCCAGCC GAAGCACTTT CCACGGGGAG CAGCTCCGAG AGCGGCGCAG TGCTGCTTAT 
AGCGGACCAC CTGCCTCCCC GTCCCATGAC ACAGCTGCAC TTGCACATGC CAGAAGGGGG 
ACGTCAACTG GGATAATCAG CAAAATCACC TCCAAGTTCG TCCGCAGGGA CCCAAGTGAA 
GGCGAAGCCA GTGGCAGAAC CGACACAGCC AGAGGTTCAT CGGGGGAGCC GAAAGACAAG 
GAAGAGGGTA AGGAGGCCAA GCCGAGGTCG CTGCGCTTCA CGTGGAGCAT GAAGACCACT 
AGTTCAATGG ACCCCAATGA CATGGTGAGA GAGATCCGCA AGGTGCTGGA TGCCAACACC 
TGTGACTATG AACAGAGAGA GAGGTTCCTG CTCTTCTGCG TTCACGGAGA CGCTCGGCAG 
GACAGCCTCG TACAGTGGGA GATGGAGGTC TGCAAGTTGC CTCGGCTCTC ACTCAATGGG 
GTCCGCTTCA AGCGAATATC CGGGACATCT ATTGCCTTTA AGAACATTGC ATCCAAAATA 
GCAAATGAGC TTAAGCTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008768038.1
CDS	1..2541
Translation	MAVPNMEQRIPSARSESVQHSSDVKKTCKDDEGNALEIREGREYQCLVNDHLKGRADALPTVNERDTENHTSVDGYTETHIPPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDLNDAKRIDIMVTMGFARDEINDALVSQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDTARRLGSTTVGSKSEVTASPLVGPDRKKSSAGPSNNVYSGGSMTRRNTYVCERSTDRYAALQNGRDSSLTEMSASSMSSTGSTVASAGPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGSTAQRVPAASPSAHSISASTPDRTRFPRGSSSRSTFHGEQLRERRSAAYSGPPASPSHDTAALAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTARGSSGEPKDKEEGKEAKPRSLRFTWSMKTTSSMDPNDMVREIRKVLDANTCDYEQRERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL

Target ORF information:

RefSeq Version	XM_008769816.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus microtubule affinity regulating kinase 1 (Mark1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008769816.2

ORF Insert Sequence:

ATGGCAGTTC CTAACATGGA ACAAAGAATC CCTTCAGCGA GAAGTGAATC AGTGCAACAC 
TCGAGTGATG TAAAGAAGAC CTGCAAAGAT GATGAGGGAA ACGCTTTAGA AATAAGAGAA 
GGGCGTGAAT ACCAGTGCCT GGTTAACGAT CATTTGAAAG GCAGAGCGGA CGCATTGCCC 
ACGGTGAACG AGCGGGACAC GGAGAACCAT ACATCTGTGG ATGGATATAC TGAAACGCAT 
ATCCCGCCTA CCAAATCAAG TAGCAGACAA AACATTCCCC GGTGTAGAAA CTCCATTACG 
TCAGCGACAG ATGAACAGCC TCACATCGGA AATTACCGTT TACAGAAAAC AATAGGGAAG 
GGGAATTTTG CCAAAGTGAA ATTGGCAAGG CATGTCCTAA CAGGTAGAGA GGTAGCTGTG 
AAAATAATAG ACAAAACTCA GCTAAACCCT ACCAGTCTAC AAAAGTTGTT CCGAGAAGTA 
CGAATAATGA AGATACTGAA CCATCCTAAC ATAGTGAAAC TGTTTGAAGT TATTGAAACA 
GAGAAGACGC TCTACCTGGT CATGGAATAC GCAAGTGGGG GTGAAGTCTT TGATTACTTA 
GTTGCCCACG GAAGAATGAA AGAGAAAGAG GCCCGGGCCA AATTCAGGCA GATTGTATCT 
GCTGTACAGT ATTGTCATCA AAAATGCATT GTCCACCGTG ATCTTAAGGC TGAAAACCTT 
CTCCTTGATG CTGATATGAA TATTAAAATT GCTGACTTTG GTTTTAGCAA TGAATTCACA 
GTGGGGAACA AATTGGACAC ATTCTGTGGA AGCCCGCCTT ATGCTGCCCC TGAGCTTTTC 
CAAGGCAAGA AGTACGACGG GCCGGAAGTG GATGTGTGGA GTCTAGGCGT CATTCTCTAC 
ACGCTGGTCA GTGGCTCCCT GCCTTTCGAT GGCCAGAATC TAAAGGAGCT CCGGGAGCGG 
GTCCTGCGAG GGAAGTACCG TGTTCCTTTC TACATGTCCA CGGACTGCGA GAACCTCCTG 
AAGAAACTGC TAGTGCTGAA CCCCATAAAG AGGGGCAGCC TGGAGCAAAT AATGAAAGAC 
CGATGGATGA ACGTTGGTCA TGAAGAGGAA GAGCTAAAAC CATATTCTGA GCCTGAGCTT 
GATCTCAATG ATGCAAAAAG AATAGACATT ATGGTCACCA TGGGTTTTGC ACGAGATGAA 
ATCAATGATG CCTTAGTAAG CCAGAAATAT GATGAGGTTA TGGCTACTTA TATTCTTCTA 
GGTAGAAAAC CACCTGAGTT CGAAGGTGGT GAGTCACTGT CCAGTGGAAA CCTTTGTCAG 
CGATCCCGGC CGAGCAGTGA CCTGAACAAC AGCACGCTTC AGTCACCTGC TCACCTGAAG 
GTCCAGCGAA GCATCTCAGC CAACCAGAAG CAGAGGCGCT TCAGTGACCA TGCCGGTCCC 
TCCATCCCCC CTGCTGTCTC ATACACCAAA AGGCCTCAGG CCAACAGCGT GGAGAGTGAA 
CAGAAAGAGG AGTGGGACAA AGACACAGCC CGCAGACTTG GCAGCACCAC CGTGGGCTCG 
AAGAGCGAAG TCACAGCCAG CCCCTTGGTG GGGCCAGACA GGAAAAAGTC CTCAGCTGGC 
CCAAGTAACA ACGTATATTC TGGCGGTAGC ATGACGAGGA GAAATACATA TGTGTGTGAG 
AGGAGCACGG ACCGGTACGC TGCCTTGCAG AATGGAAGAG ACAGCAGCCT TACAGAGATG 
TCTGCCAGCA GCATGTCCTC CACAGGTTCC ACTGTGGCCT CTGCTGGCCC CTCAGCACGT 
CCCCGCCACC AGAAGTCTAT GTCAACCTCT GGCCACCCTA TTAAAGTTAC ACTGCCAACC 
ATTAAAGATG GCTCTGAAGC TTATCGGCCT GGCAGTACAG CTCAGAGAGT GCCTGCTGCT 
TCCCCGTCTG CTCACAGCAT TAGTGCCAGT ACTCCTGACA GGACCCGCTT CCCCCGAGGG 
AGCTCCAGCC GAAGCACTTT CCACGGGGAG CAGCTCCGAG AGCGGCGCAG TGCTGCTTAT 
AGCGGACCAC CTGCCTCCCC GTCCCATGAC ACAGCTGCAC TTGCACATGC CAGAAGGGGG 
ACGTCAACTG GGATAATCAG CAAAATCACC TCCAAGTTCG TCCGCAGGGA CCCAAGTGAA 
GGCGAAGCCA GTGGCAGAAC CGACACAGCC AGAGGTTCAT CGGGGGAGCC GAAAGACAAG 
GAAGAGGGTA AGGAGGCCAA GCCGAGGTCG CTGCGCTTCA CGTGGAGCAT GAAGACCACT 
AGTTCAATGG ACCCCAATGA CATGGTGAGA GAGATCCGCA AGGTGCTGGA TGCCAACACC 
TGTGACTATG AACAGAGAGA GAGGTTCCTG CTCTTCTGCG TTCACGGAGA CGCTCGGCAG 
GACAGCCTCG TACAGTGGGA GATGGAGGTC TGCAAGTTGC CTCGGCTCTC ACTCAATGGG 
GTCCGCTTCA AGCGAATATC CGGGACATCT ATTGCCTTTA AGAACATTGC ATCCAAAATA 
GCAAATGAGC TTAAGCTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
PloS one10(5)e0124816(2015)
Bernard LP,Zhang H

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.
Neuromolecular medicine15(3)458-69(2013 Sep)
Gu GJ,Lund H,Wu D,Blokzijl A,Classon C,von Euler G,Landegren U,Sunnemark D,Kamali-Moghaddam M

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.
Cell143(6)966-77(2010 Dec)
Moravcevic K,Mendrola JM,Schmitz KR,Wang YH,Slochower D,Janmey PA,Lemmon MA

Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.
Human molecular genetics17(16)2541-51(2008 Aug)
Maussion G,Carayol J,Lepagnol-Bestel AM,Tores F,Loe-Mie Y,Milbreta U,Rousseau F,Fontaine K,Renaud J,Moalic JM,Philippi A,Chedotal A,Gorwood P,Ramoz N,Hager J,Simonneau M

Microtubule affinity-regulating kinase 1 (MARK1) is activated by electroconvulsive shock in the rat hippocampus.
Journal of neurochemistry95(6)1608-18(2005 Dec)
Jeon S,Kim YS,Park J,Bae CD

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Mark1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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