Eif3c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eif3c
Entrez Gene ID	56347
Full Name	eukaryotic translation initiation factor 3, subunit C
Synonyms	110kDa,3230401O13Rik,Eif3s8,NIPIL(A3),NipilA3,Xs,Xsl
General protein information	Preferred Names eukaryotic translation initiation factor 3, subunit C Names eukaryotic translation initiation factor 3 subunit C NIPI-like protein eIF3 p110 eIF3c eukaryotic translation initiation factor 3 subunit 8 eukaryotic translation initiation factor 3, subunit 8 (110 kDa) extra-toes spotting
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 69.14 cM\|7 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_146200.1	NP_666312.1	eukaryotic translation initiation factor 3 subunit C

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0F03014g	XP_455216.1
Schizosaccharomyces pombe (fission yeast)	tif33	NP_593828.2
Arabidopsis thaliana (thale cress)	EIF3C	NP_001190102.1
Xenopus tropicalis (tropical clawed frog)	eif3c	NP_989413.1
Canis lupus familiaris (dog)	EIF3C	XP_536923.2
Bos taurus (cattle)	EIF3CL	NP_001029790.1
Mus musculus (house mouse)	Eif3c	NP_666312.1
Rattus norvegicus (Norway rat)	Eif3c	NP_001094132.1
Homo sapiens (human)	EIF3C	NP_003743.1
Saccharomyces cerevisiae (baker's yeast)	NIP1	NP_014040.1
Eremothecium gossypii	AGOS_AGL344C	NP_986323.1
Danio rerio (zebrafish)	eif3c	NP_998628.1
Drosophila melanogaster (fruit fly)	eIF3-S8	NP_611242.1
Arabidopsis thaliana (thale cress)	TIF3C2	NP_188926.4
Oryza sativa (rice)	Os07g0124500	NP_001058804.1
Magnaporthe oryzae (rice blast fungus)	MGG_16895	XP_003712797.1
Macaca mulatta (Rhesus monkey)	LOC705696	XP_002808338.1
Caenorhabditis elegans (roundworm)	eif-3.C	NP_492638.1
Anopheles gambiae (African malaria mosquito)	EIF3C_ANOGA	XP_318103.3
Neurospora crassa	NCU07831	XP_962952.1

Gene Ontology
Bibliography

Related articles in PubMed

The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.
Zeng L, Wan Y, Li D, Wu J, Shao M, Chen J, Hui L, Ji H, Zhu X
The Journal of biological chemistry288(42)30087-93(2013 Oct)

The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.
Gildea DE, Luetkemeier ES, Bao X, Loftus SK, Mackem S, Yang Y, Pavan WJ, Biesecker LG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology25(5)1596-605(2011 May)

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ
PLoS genetics5(6)e1000511(2009 Jun)

Reconstitution reveals the functional core of mammalian eIF3.
Masutani M, Sonenberg N, Yokoyama S, Imataka H
The EMBO journal26(14)3373-83(2007 Jul)

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Molecular & cellular proteomics : MCP6(2)283-93(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Eif3c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif3c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18013	NM_146200.1 Latest version!	Mus musculus eukaryotic translation initiation factor 3, subunit C (Eif3c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$531.30 $759.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eif3c ( NM_146200.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666312.1 Mus musculus eukaryotic translation initiation factor 3, subunit C (Eif3c), mRNA.

Price & Availability↑

CloneID	OMu18013
Clone ID Related Accession (Same CDS sequence)	NM_146200.1
Accession Version	NM_146200.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2736bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569168000000
Organism	Mus musculus(house mouse)
Product	eukaryotic translation initiation factor 3 subunit C
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC024855.1. On or before Dec 7, 2005 this sequence version replaced XM_914725.1, NM_019646.1. ##Evidence-Data-START## Transcript exon combination :: BC024855.1, BC025032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164137 [ECO:0000348] ##Evidence-Data-END##

ATGTCGCGAT TCTTCACCAC CGGCTCGGAC AGTGAGTCGG AGTCGTCCCT GTCCGGGGAG 
GAGCTCGTCA CCAAACCGGT CTCCGGGAAC TACGGCAAAC AGCCTTTGTT ACTGAGCGAG 
GATGAGGAGG ATACAAAGAG AGTTGTCCGA AGCGCCAAGG ACAAGAGGTT TGAGGAGCTG 
ACCAACCTCA TACGAACCAT CCGTAATGCC ATGAAGATTC GAGATGTCAC CAAGTGTCTA 
GAAGAGTTTG AGCTCCTGGG AAAGGCCTAT GGGAAAGCCA AGAGTATTGT GGATAAGGAA 
GGTGTCCCCC GATTCTACAT CCGAATACTG GCTGACCTGG AGGACTATCT TAATGAGCTT 
TGGGAAGATA AAGAAGGAAA GAAGAAGATG AATAAAAACA ACGCCAAGGC TCTGAGTACC 
TTGCGCCAGA AGATCCGGAA ATACAACCGA GATTTCGAGT CACACATCAC CAACTACAAG 
CAGAACCCTG AGCAGTCTGC AGATGAAGAT GCAGAAAAGA ATGAGGAAGA CTCCGAAGGC 
TCTTCAGATG AGGATGAGGA CGAGGACGGA GTCGGTAATA CGACTTTCTT GAAGAAGAAG 
CAAGAATCTT CTGGAGAGAG TCGGAAGTTC CACAAAAAGA TGGAAGATGA TGATGAGGAC 
TCTGAAGATT CTGAAGATGA AGAATGGGAC ACCAGCTCCA CATCTTCTGA TTCAGACTCT 
GAGGAAGAAG AAGGAAAACA AACTGTTCTG GCCTCAAAGT TCCTTAAAAA GGCACCCACT 
ACAGAGGAGG ACAAAAAAGC AGCTGAAAAG AAACGGGAAG ACAAAGCCAA GAAGAAGCAC 
GATAGGAAGT CTAAGCGCCT GGATGAGGAA GAGGAGGACA ATGAGGGCGG GGAGTGGGAA 
CGGGTCCGAG GTGGCGTACC ACTTGTTAAG GAAAAGCCAA AAATGTTTGC CAAGGGAACT 
GAGATCACTC ATGCTGTTGT CATCAAGAAA CTGAATGAGA TTCTACAGGT CAGAGGCAAG 
AAGGGAACAG ACCGTGCCAC TCAGATTGAA TTGCTCCAGC TGCTGGTTCA GATTGCTGCT 
GAAAACAACC TGGGGGTGGG CGTCATTGTC AAGATCAAGT TCAATATCAT TGCCTCTCTC 
TACGATTACA ACCCTAACCT GGCCACGTAC ATGAAGCCAG AGATGTGGCA GATGTGCCTA 
GACTGCATCA ATGAACTGAT GGATACGTTG GTTGCACATT CCAACATCTT TGTTGGAGAG 
AACATTTTGG AAGAGAGTGA GAACTTACAC AACTTTGATC AGCCACTGCG TGTACGAGGC 
TGCATCCTAA CTTTGGTGGA GCGAATGGAT GAAGAATTTA CCAAAATAAT GCAAAATACT 
GATCCTCACT CCCAAGAGTA TGTGGAGCAC CTGAAGGATG AGGCACAAGT GTGTGCCATC 
ATTGAGCGAG TGCAGCGCTA CCTGGAGGAG AAAGGTACCA CTGAGGAGAT CTGCCAGATC 
TACTTAAGGC GCATCCTGCA CACGTACTAC AAGTTTGACT ACAAGGCCCA TCAGCGGCAG 
CTTACTCCTC CTGAAGGATC CTCAAAGTCT GAGCAAGACC AGGCAGAAAA TGAGGGTGAG 
GACTCAGCTG TGCTAATGGA AAGACTGTGC AAGTACATCT ATGCCAAGGA CCGTACAGAC 
CGGATCCGTA CCTGTGCCAT CCTCTGCCAT ATCTACCATC ATGCGCTCCA CTCCCGCTGG 
TATCAGGCCC GTGACCTCAT GCTCATGAGC CACCTACAGG ACAACATTCA GCACGCAGAC 
CCGCCGGTGC AGATCCTGTA TAACCGTACT ATGGTGCAAC TGGGCATCTG TGCTTTCCGC 
CAAGGCCTGA CAAAGGATGC ACACAATGCA CTTCTGGATA TTCAGTCAAG TGGTCGTGCC 
AAGGAGCTTC TAGGTCAGGG TCTGCTGCTG CGCAGCCTGC AGGAGCGAAA TCAGGAACAG 
GAAAAGGTAG AGCGACGCCG GCAGGTGCCC TTTCACCTGC ACATCAACCT GGAGCTGCTG 
GAGTGTGTCT ATCTGGTGTC AGCTATGCTC CTGGAGATCC CCTACATGGC TGCCCATGAG 
AGCGATGCCC GCCGACGCAT GATCAGCAAG CAGTTCCACC ACCAACTGCG GGTGGGCGAG 
CGGCAGCCCC TGCTAGGTCC TCCCGAGTCA ATGAGGGAGC ATGTGGTCGC TGCCTCCAAG 
GCCATGAAGA TGGGCGACTG GAAGACCTGC CACAGTTTCA TCATTAATGA AAAGATGAAT 
GGGAAAGTGT GGGACCTTTT CCCTGAGGCT GACAAAGTTC GCACCATGCT AGTTCGGAAG 
ATCCAGGAAG AGTCTCTGAG GACCTACCTT TTTACCTACA GCAGTGTCTA TGACTCAATC 
AGTATGGAGA CACTATCAGA TATGTTTGAG CTGGATCTAC CCACTGTTCA CTCCATCATC 
AGCAAGATGA TCATTAACGA AGAATTGATG GCTTCCCTGG ACCAGCCGAC ACAGACTGTG 
GTGATGCACC GTACTGAGCC CACTGCCCAG CAGAACTTGG CTCTGCAGCT GGCTGAGAAG 
CTTGGCAGCC TAGTGGAGAA TAATGAACGG GTGTTTGACC ATAAGCAGGG AACCTATGGT 
GGCTATTTCC GAGACCAAAA GGATGGCTAC CGAAAAAATG AAGGCTATAT GCGCCGTGGT 
GGCTACCGCC AGCAGCAGTC TCAGACAGCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666312.1
CDS	60..2795
Translation	MSRFFTTGSDSESESSLSGEELVTKPVSGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITNYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGVGNTTFLKKKQESSGESRKFHKKMEDDDEDSEDSEDEEWDTSSTSSDSDSEEEEGKQTVLASKFLKKAPTTEEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQVRGKKGTDRATQIELLQLLVQIAAENNLGVGVIVKIKFNIIASLYDYNPNLATYMKPEMWQMCLDCINELMDTLVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY

Target ORF information:

RefSeq Version	NM_146200.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus eukaryotic translation initiation factor 3, subunit C (Eif3c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146200.1

ORF Insert Sequence:

ATGTCGCGAT TCTTCACCAC CGGCTCGGAC AGTGAGTCGG AGTCGTCCCT GTCCGGGGAG 
GAGCTCGTCA CCAAACCGGT CTCCGGGAAC TACGGCAAAC AGCCTTTGTT ACTGAGCGAG 
GATGAGGAGG ATACAAAGAG AGTTGTCCGA AGCGCCAAGG ACAAGAGGTT TGAGGAGCTG 
ACCAACCTCA TACGAACCAT CCGTAATGCC ATGAAGATTC GAGATGTCAC CAAGTGTCTA 
GAAGAGTTTG AGCTCCTGGG AAAGGCCTAT GGGAAAGCCA AGAGTATTGT GGATAAGGAA 
GGTGTCCCCC GATTCTACAT CCGAATACTG GCTGACCTGG AGGACTATCT TAATGAGCTT 
TGGGAAGATA AAGAAGGAAA GAAGAAGATG AATAAAAACA ACGCCAAGGC TCTGAGTACC 
TTGCGCCAGA AGATCCGGAA ATACAACCGA GATTTCGAGT CACACATCAC CAACTACAAG 
CAGAACCCTG AGCAGTCTGC AGATGAAGAT GCAGAAAAGA ATGAGGAAGA CTCCGAAGGC 
TCTTCAGATG AGGATGAGGA CGAGGACGGA GTCGGTAATA CGACTTTCTT GAAGAAGAAG 
CAAGAATCTT CTGGAGAGAG TCGGAAGTTC CACAAAAAGA TGGAAGATGA TGATGAGGAC 
TCTGAAGATT CTGAAGATGA AGAATGGGAC ACCAGCTCCA CATCTTCTGA TTCAGACTCT 
GAGGAAGAAG AAGGAAAACA AACTGTTCTG GCCTCAAAGT TCCTTAAAAA GGCACCCACT 
ACAGAGGAGG ACAAAAAAGC AGCTGAAAAG AAACGGGAAG ACAAAGCCAA GAAGAAGCAC 
GATAGGAAGT CTAAGCGCCT GGATGAGGAA GAGGAGGACA ATGAGGGCGG GGAGTGGGAA 
CGGGTCCGAG GTGGCGTACC ACTTGTTAAG GAAAAGCCAA AAATGTTTGC CAAGGGAACT 
GAGATCACTC ATGCTGTTGT CATCAAGAAA CTGAATGAGA TTCTACAGGT CAGAGGCAAG 
AAGGGAACAG ACCGTGCCAC TCAGATTGAA TTGCTCCAGC TGCTGGTTCA GATTGCTGCT 
GAAAACAACC TGGGGGTGGG CGTCATTGTC AAGATCAAGT TCAATATCAT TGCCTCTCTC 
TACGATTACA ACCCTAACCT GGCCACGTAC ATGAAGCCAG AGATGTGGCA GATGTGCCTA 
GACTGCATCA ATGAACTGAT GGATACGTTG GTTGCACATT CCAACATCTT TGTTGGAGAG 
AACATTTTGG AAGAGAGTGA GAACTTACAC AACTTTGATC AGCCACTGCG TGTACGAGGC 
TGCATCCTAA CTTTGGTGGA GCGAATGGAT GAAGAATTTA CCAAAATAAT GCAAAATACT 
GATCCTCACT CCCAAGAGTA TGTGGAGCAC CTGAAGGATG AGGCACAAGT GTGTGCCATC 
ATTGAGCGAG TGCAGCGCTA CCTGGAGGAG AAAGGTACCA CTGAGGAGAT CTGCCAGATC 
TACTTAAGGC GCATCCTGCA CACGTACTAC AAGTTTGACT ACAAGGCCCA TCAGCGGCAG 
CTTACTCCTC CTGAAGGATC CTCAAAGTCT GAGCAAGACC AGGCAGAAAA TGAGGGTGAG 
GACTCAGCTG TGCTAATGGA AAGACTGTGC AAGTACATCT ATGCCAAGGA CCGTACAGAC 
CGGATCCGTA CCTGTGCCAT CCTCTGCCAT ATCTACCATC ATGCGCTCCA CTCCCGCTGG 
TATCAGGCCC GTGACCTCAT GCTCATGAGC CACCTACAGG ACAACATTCA GCACGCAGAC 
CCGCCGGTGC AGATCCTGTA TAACCGTACT ATGGTGCAAC TGGGCATCTG TGCTTTCCGC 
CAAGGCCTGA CAAAGGATGC ACACAATGCA CTTCTGGATA TTCAGTCAAG TGGTCGTGCC 
AAGGAGCTTC TAGGTCAGGG TCTGCTGCTG CGCAGCCTGC AGGAGCGAAA TCAGGAACAG 
GAAAAGGTAG AGCGACGCCG GCAGGTGCCC TTTCACCTGC ACATCAACCT GGAGCTGCTG 
GAGTGTGTCT ATCTGGTGTC AGCTATGCTC CTGGAGATCC CCTACATGGC TGCCCATGAG 
AGCGATGCCC GCCGACGCAT GATCAGCAAG CAGTTCCACC ACCAACTGCG GGTGGGCGAG 
CGGCAGCCCC TGCTAGGTCC TCCCGAGTCA ATGAGGGAGC ATGTGGTCGC TGCCTCCAAG 
GCCATGAAGA TGGGCGACTG GAAGACCTGC CACAGTTTCA TCATTAATGA AAAGATGAAT 
GGGAAAGTGT GGGACCTTTT CCCTGAGGCT GACAAAGTTC GCACCATGCT AGTTCGGAAG 
ATCCAGGAAG AGTCTCTGAG GACCTACCTT TTTACCTACA GCAGTGTCTA TGACTCAATC 
AGTATGGAGA CACTATCAGA TATGTTTGAG CTGGATCTAC CCACTGTTCA CTCCATCATC 
AGCAAGATGA TCATTAACGA AGAATTGATG GCTTCCCTGG ACCAGCCGAC ACAGACTGTG 
GTGATGCACC GTACTGAGCC CACTGCCCAG CAGAACTTGG CTCTGCAGCT GGCTGAGAAG 
CTTGGCAGCC TAGTGGAGAA TAATGAACGG GTGTTTGACC ATAAGCAGGG AACCTATGGT 
GGCTATTTCC GAGACCAAAA GGATGGCTAC CGAAAAAATG AAGGCTATAT GCGCCGTGGT 
GGCTACCGCC AGCAGCAGTC TCAGACAGCC TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.
The Journal of biological chemistry288(42)30087-93(2013 Oct)
Zeng L,Wan Y,Li D,Wu J,Shao M,Chen J,Hui L,Ji H,Zhu X

The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology25(5)1596-605(2011 May)
Gildea DE,Luetkemeier ES,Bao X,Loftus SK,Mackem S,Yang Y,Pavan WJ,Biesecker LG

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
PLoS genetics5(6)e1000511(2009 Jun)
Sansom SN,Griffiths DS,Faedo A,Kleinjan DJ,Ruan Y,Smith J,van Heyningen V,Rubenstein JL,Livesey FJ

Reconstitution reveals the functional core of mammalian eIF3.
The EMBO journal26(14)3373-83(2007 Jul)
Masutani M,Sonenberg N,Yokoyama S,Imataka H

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Molecular & cellular proteomics : MCP6(2)283-93(2007 Feb)
Munton RP,Tweedie-Cullen R,Livingstone-Zatchej M,Weinandy F,Waidelich M,Longo D,Gehrig P,Potthast F,Rutishauser D,Gerrits B,Panse C,Schlapbach R,Mansuy IM

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Eif3c cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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