Uts2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Uts2
Entrez Gene ID	24111
Full Name	urotensin 2
Synonyms	UII,Ucn2,prepro-UII
General protein information	Preferred Names urotensin 2 Names urotensin-2 urotensin-II
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 E2
Summary	This gene encodes a member of the urotensin family of peptide hormones. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone before secretion into the plasma. Mice lacking the encoded protein have a significantly decreased low density lipoprotein cholesterol profile and hepatic steatosis that is consistent with decreased hepatocyte de novo cholesterol synthesis and apolipoprotein B secretion. [provided by RefSeq, Sep 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_011910.2	NP_036040.1	urotensin-2 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Uts2	NP_036040.1
Rattus norvegicus (Norway rat)	Uts2	NP_062033.1
Canis lupus familiaris (dog)	UTS2	XP_005620655.1
Bos taurus (cattle)	UTS2	XP_002694098.1
Homo sapiens (human)	UTS2	NP_006777.1
Macaca mulatta (Rhesus monkey)	UTS2	NP_001028067.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions.
Ugan RA, Cadirci E, Halici Z, Toktay E, Cinar I
European journal of pharmacology818457-469(2018 Jan)

IRF3 is an important molecule in the UII/UT system and mediates immune inflammatory injury in acute liver failure.
Liu LM, Tu WJ, Zhu T, Wang XT, Tan ZL, Zhong H, Gao DY, Liang DY
Oncotarget7(31)49027-49041(2016 Aug)

Effects of urotensin-II on cytokines in early acute liver failure in mice.
Liu LM, Zhao L, Liang DY, Yu FP, Ye CG, Tu WJ, Zhu T
World journal of gastroenterology21(11)3239-44(2015 Mar)

Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-κB pathway in ALF mice.
Liang DY, Liu LM, Ye CG, Zhao L, Yu FP, Gao DY, Wang YY, Yang ZW, Wang YY
PloS one8(6)e64895(2014)

Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes.
Watson AM, Olukman M, Koulis C, Tu Y, Samijono D, Yuen D, Lee C, Behm DJ, Cooper ME, Jandeleit-Dahm KA, Calkin AC, Allen TJ
Diabetologia56(5)1155-65(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Uts2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Uts2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09141	NM_011910.2 Latest version!	Mus musculus urotensin 2 (Uts2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Uts2 ( NM_011910.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036040.1 Mus musculus urotensin 2 (Uts2), mRNA.

Price & Availability↑

CloneID	OMu09141
Clone ID Related Accession (Same CDS sequence)	NM_011910.2
Accession Version	NM_011910.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569168000000
Organism	Mus musculus(house mouse)
Product	urotensin-2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL607143.14 and BC107299.1. On Jul 29, 2009 this sequence version replaced NM_011910.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF172175.1, BC107299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164136, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGGACAGGG TGCCCTTCTG CTGCCTGCTC TTCATAGGAC TTCTGAATCC ACTGCTGTCC 
CTTCCCGTCA CGGACACTGG TGAGAGGACT CTTCAGCTTC CAGTGCTTGA GGAAGACGCT 
CTTCGGGCTC TGGAGGAGCT GGAGAGGATG GCCCTCCTGC AGACCCTGCG TCAGACCATG 
GGCACGGAAG CAGGGGAGAG CCCTGGAGAA GCAGGTCCCA GCACTGAGAC TCCCACTCCA 
CGGGGAAGCA TGAGGAAGGC TTTCGCTGGG CAAAATTCTA ACACTGTACT GAGTCGTCTC 
TTGGCAAGAA CCAGGAAACA ACATAAGCAA CACGGGGCTG CCCCAGAGTG CTTCTGGAAA 
TACTGCATTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036040.1
CDS	37..408
Translation	MDRVPFCCLLFIGLLNPLLSLPVTDTGERTLQLPVLEEDALRALEELERMALLQTLRQTMGTEAGESPGEAGPSTETPTPRGSMRKAFAGQNSNTVLSRLLARTRKQHKQHGAAPECFWKYCI

Target ORF information:

RefSeq Version	NM_011910.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus urotensin 2 (Uts2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011910.2

ORF Insert Sequence:

ATGGACAGGG TGCCCTTCTG CTGCCTGCTC TTCATAGGAC TTCTGAATCC ACTGCTGTCC 
CTTCCCGTCA CGGACACTGG TGAGAGGACT CTTCAGCTTC CAGTGCTTGA GGAAGACGCT 
CTTCGGGCTC TGGAGGAGCT GGAGAGGATG GCCCTCCTGC AGACCCTGCG TCAGACCATG 
GGCACGGAAG CAGGGGAGAG CCCTGGAGAA GCAGGTCCCA GCACTGAGAC TCCCACTCCA 
CGGGGAAGCA TGAGGAAGGC TTTCGCTGGG CAAAATTCTA ACACTGTACT GAGTCGTCTC 
TTGGCAAGAA CCAGGAAACA ACATAAGCAA CACGGGGCTG CCCCAGAGTG CTTCTGGAAA 
TACTGCATTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions.
European journal of pharmacology818457-469(2018 Jan)
Ugan RA,Cadirci E,Halici Z,Toktay E,Cinar I

IRF3 is an important molecule in the UII/UT system and mediates immune inflammatory injury in acute liver failure.
Oncotarget7(31)49027-49041(2016 Aug)
Liu LM,Tu WJ,Zhu T,Wang XT,Tan ZL,Zhong H,Gao DY,Liang DY

Effects of urotensin-II on cytokines in early acute liver failure in mice.
World journal of gastroenterology21(11)3239-44(2015 Mar)
Liu LM,Zhao L,Liang DY,Yu FP,Ye CG,Tu WJ,Zhu T

Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-κB pathway in ALF mice.
PloS one8(6)e64895(2014)
Liang DY,Liu LM,Ye CG,Zhao L,Yu FP,Gao DY,Wang YY,Yang ZW,Wang YY

Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes.
Diabetologia56(5)1155-65(2013 May)
Watson AM,Olukman M,Koulis C,Tu Y,Samijono D,Yuen D,Lee C,Behm DJ,Cooper ME,Jandeleit-Dahm KA,Calkin AC,Allen TJ