Mbd3l2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mbd3l2
Entrez Gene ID	234988
Full Name	methyl-CpG binding domain protein 3-like 2
General protein information	Preferred Names methyl-CpG binding domain protein 3-like 2 Names methyl-CpG binding domain protein 3-like 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_144934.3	NP_659183.3	methyl-CpG binding domain protein 3-like 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	MBD3L4	NP_001157891.1
Homo sapiens (human)	MBD3L3	NP_001157897.1
Pan troglodytes (chimpanzee)	MBD3L2	XP_001165954.1
Rattus norvegicus (Norway rat)	LOC100912114	XP_003752238.1
Rattus norvegicus (Norway rat)	LOC100363016	XP_002729925.1
Pan troglodytes (chimpanzee)	MBD3L2	XP_001144438.1
Pan troglodytes (chimpanzee)	MBD3L2	XP_524079.2
Macaca mulatta (Rhesus monkey)	LOC705273	XP_001093645.1
Macaca mulatta (Rhesus monkey)	LOC705142	XP_001093522.1
Bos taurus (cattle)	MBD3L3	XP_002688877.2
Mus musculus (house mouse)	Mbd3l2	NP_659183.3
Rattus norvegicus (Norway rat)	Mbd3l2	XP_235852.3
Canis lupus familiaris (dog)	LOC100688619	XP_003432915.2
Homo sapiens (human)	LOC729458	XP_001130308.1
Pan troglodytes (chimpanzee)	LOC749125	XP_001165749.2
Pan troglodytes (chimpanzee)	MBD3L2	XP_001165919.1
Pan troglodytes (chimpanzee)	MBD3L2	XP_001165993.1
Homo sapiens (human)	MBD3L5	NP_001129979.1
Homo sapiens (human)	MBD3L2	NP_653215.2

Gene Ontology
Bibliography

Related articles in PubMed

Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.
Jin SG, Tsark W, Szabó PE, Pfeifer GP
Developmental dynamics : an official publication of the American Association of Anatomists237(11)3435-43(2008 Nov)

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.
Jin SG, Jiang CL, Rauch T, Li H, Pfeifer GP
The Journal of biological chemistry280(13)12700-9(2005 Apr)

MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.
Jiang CL, Jin SG, Lee DH, Lan ZJ, Xu X, O'Connor TR, Szabó PE, Mann JR, Cooney AJ, Pfeifer GP
Genomics80(6)621-9(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mbd3l2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mbd3l2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu25321	NM_144934.3 Latest version!	Mus musculus methyl-CpG binding domain protein 3-like 2 (Mbd3l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mbd3l2 ( NM_144934.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_659183.3 Mus musculus methyl-CpG binding domain protein 3-like 2 (Mbd3l2), mRNA.

Price & Availability↑

CloneID	OMu25321
Clone ID Related Accession (Same CDS sequence)	NM_144934.3
Accession Version	NM_144934.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527350400000
Organism	Mus musculus(house mouse)
Product	methyl-CpG binding domain protein 3-like 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC162941.5, AK135772.1 and BC064744.1. On Aug 6, 2009 this sequence version replaced NM_144934.2. ##Evidence-Data-START## Transcript exon combination :: BC064744.1, AK135772.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAGGAGA CTTCAAGAAA CTCAGTTTCA AGCCAGCCTT TGATAGGAAG TCTCACAAGA 
AGTATGATAC TCAACAAATT ACAGAAGAGA AGAGAGACCC AGATTGTCCC GAAAAAGATA 
AAGGCCAAAC ATAGAACTGG TGTTACTTCC AAAGATTCTA TGAGGATGAC CAGTTGCATC 
TTTGCAAAGC CAGTGACCAC AATAACTTCA TACCCTGAGA ATGAAACCAG GTACAGGAGA 
GAGGAAGATA AGCTGACAAA ACCCAAGCAG CTCTGTGCAC TTAAGAGACT GAAGAAACAT 
CAAGTTGGAG AGAATAAACA GGACCTGTCA TGTCAATTGA AGCTTACAAA CCCTGTAGAA 
AGAATTGCAC TGGGAATGCG GGATGAAACT AATGACCAAA GTGGTGTTAA GGGTCAGCTT 
ACTCCTGGAG AAGTTACCTC TGTCCAAACC CCATGCTTGG AAAAAAATGA ACAAATGGCT 
TTTCAGCTGT CACCATTTTT CTCCAGTCCA GGGGTAACAA TGCCAGTGCG TCTTCATCTG 
TCACCATCTT ACTTCATCCA AGAAGTAACT ATTGCAGACA TCCTGAGTCA GATCTGGAAG 
GTAAAGAAAG CCAGGAAGAG ACTGGAAGTA GCCTTGGAGG CAGACAGTCT TGCCAGGCAG 
GCAGAGAACA TGGGGGAGCA AAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659183.3
CDS	220..906
Translation	MEETSRNSVSSQPLIGSLTRSMILNKLQKRRETQIVPKKIKAKHRTGVTSKDSMRMTSCIFAKPVTTITSYPENETRYRREEDKLTKPKQLCALKRLKKHQVGENKQDLSCQLKLTNPVERIALGMRDETNDQSGVKGQLTPGEVTSVQTPCLEKNEQMAFQLSPFFSSPGVTMPVRLHLSPSYFIQEVTIADILSQIWKVKKARKRLEVALEADSLARQAENMGEQR

Target ORF information:

RefSeq Version	NM_144934.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus methyl-CpG binding domain protein 3-like 2 (Mbd3l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144934.3

ORF Insert Sequence:

ATGGAGGAGA CTTCAAGAAA CTCAGTTTCA AGCCAGCCTT TGATAGGAAG TCTCACAAGA 
AGTATGATAC TCAACAAATT ACAGAAGAGA AGAGAGACCC AGATTGTCCC GAAAAAGATA 
AAGGCCAAAC ATAGAACTGG TGTTACTTCC AAAGATTCTA TGAGGATGAC CAGTTGCATC 
TTTGCAAAGC CAGTGACCAC AATAACTTCA TACCCTGAGA ATGAAACCAG GTACAGGAGA 
GAGGAAGATA AGCTGACAAA ACCCAAGCAG CTCTGTGCAC TTAAGAGACT GAAGAAACAT 
CAAGTTGGAG AGAATAAACA GGACCTGTCA TGTCAATTGA AGCTTACAAA CCCTGTAGAA 
AGAATTGCAC TGGGAATGCG GGATGAAACT AATGACCAAA GTGGTGTTAA GGGTCAGCTT 
ACTCCTGGAG AAGTTACCTC TGTCCAAACC CCATGCTTGG AAAAAAATGA ACAAATGGCT 
TTTCAGCTGT CACCATTTTT CTCCAGTCCA GGGGTAACAA TGCCAGTGCG TCTTCATCTG 
TCACCATCTT ACTTCATCCA AGAAGTAACT ATTGCAGACA TCCTGAGTCA GATCTGGAAG 
GTAAAGAAAG CCAGGAAGAG ACTGGAAGTA GCCTTGGAGG CAGACAGTCT TGCCAGGCAG 
GCAGAGAACA TGGGGGAGCA AAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists237(11)3435-43(2008 Nov)
Jin SG,Tsark W,Szabó PE,Pfeifer GP

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.
The Journal of biological chemistry280(13)12700-9(2005 Apr)
Jin SG,Jiang CL,Rauch T,Li H,Pfeifer GP

MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.
Genomics80(6)621-9(2002 Dec)
Jiang CL,Jin SG,Lee DH,Lan ZJ,Xu X,O'Connor TR,Szabó PE,Mann JR,Cooney AJ,Pfeifer GP