Ttll3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ttll3
Entrez Gene ID	101100
Full Name	tubulin tyrosine ligase-like family, member 3
Synonyms	4833441J24Rik,AI450050
General protein information	Preferred Names tubulin tyrosine ligase-like family, member 3 Names tubulin monoglycylase TTLL3 TTL domain protein ttll3 tubulin--tyrosine ligase-like protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001142732.1	NP_001136204.1	tubulin monoglycylase TTLL3 isoform 2
NM_133923.6	NP_598684.4	tubulin monoglycylase TTLL3 isoform 1
NM_133923.7	NP_598684.4	tubulin monoglycylase TTLL3 isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ttll3	NP_598684.4
Homo sapiens (human)	TTLL3	NP_001021100.3
Pan troglodytes (chimpanzee)	TTLL3	XP_517039.3
Rattus norvegicus (Norway rat)	Ttll3	NP_001102110.2

Gene Ontology
Bibliography

Related articles in PubMed

Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration.
Bosch Grau M, Masson C, Gadadhar S, Rocha C, Tort O, Marques Sousa P, Vacher S, Bieche I, Janke C
Journal of cell science130(5)938-949(2017 03)

Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.
Rocha C, Papon L, Cacheux W, Marques Sousa P, Lascano V, Tort O, Giordano T, Vacher S, Lemmers B, Mariani P, Meseure D, Medema JP, Bièche I, Hahne M, Janke C
The EMBO journal33(19)2247-60(2014 Oct)

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Adissu HA, Estabel J, Sunter D, Tuck E, Hooks Y, Carragher DM, Clarke K, Karp NA, , Newbigging S, Jones N, Morikawa L, White JK, McKerlie C
Disease models & mechanisms7(5)515-24(2014 May)

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.
Bosch Grau M, Gonzalez Curto G, Rocha C, Magiera MM, Marques Sousa P, Giordano T, Spassky N, Janke C
The Journal of cell biology202(3)441-51(2013 Aug)

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.
Rogowski K, Juge F, van Dijk J, Wloga D, Strub JM, Levilliers N, Thomas D, Bré MH, Van Dorsselaer A, Gaertig J, Janke C
Cell137(6)1076-87(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ttll3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ttll3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13138	NM_001142732.1 Latest version!	Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu13201	NM_133923.7 Latest version!	Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OMu13201	NM_133923.6	Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ttll3 ( NM_001142732.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001136204.1 Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13138
Clone ID Related Accession (Same CDS sequence)	NM_001142732.1
Accession Version	NM_001142732.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550592000000
Organism	Mus musculus(house mouse)
Product	tubulin monoglycylase TTLL3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK029462.1, AM690746.1 and CF916454.1. Transcript Variant: This variant has an alternate 5' exon and lacks multiple 3' exons but has an alternate 3' end sequence, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus and a shorter and different C-terminus, as compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK029462.1, BC021404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCGAC TCAGAAACGC CAAAATCCAC GTAGAGAGAG CCGTCAAGCA GAAGAAGATC 
TTTATGATTC ATGGCCGATA CCCAGTGATC CGGTGTCTCT TGCGTCAGAG GGGCTGGGTA 
GAGAAGAAGA TGGTGCATCC CCCAGGCACA GCCCTGCCAG CACCCCAGAA GGATCTCGAT 
AGCTCCATGC TGGGTGATAG CGATGCCACG GAGGATGAGG ATGAGGAAGA GAACGAAATG 
TTTCGGGAGT CGCAGCTGTT GGACTTGGAT GGTTTCCTGG AATTTGATGA CCTAGATGGG 
ATACATGCTT TGATGTCCCG CATGGTTCGA AATGAGACCC CCTACCTCAT CTGGACCACT 
CGGCGGGATG TGCTGGATTG TCGCTTCCTT TCCAAGGATC AGATGATAAA CCATTATGCC 
CGTGCAGGCT CCTTCACCAC AAAGGTGGGC CTTTGTCTCA ACCTCCGGAA TCTGCCGTGG 
TTTGATGAGG CCGATGCTGA CTCTTTCTTC CCACGATGCT ACCGATTGGG GGCAGAGGAT 
GACAAGAAAG CCTTCATAGG TAAGGGGACT CCAATCCCAG GCCTGGCTCC CTCATGCTGT 
CTGTCCCACA GGGGAAAAGA GCAAGCCTCC CCTTGTGGCC TCTGTAACCC CAGCCCTTTC 
CTCCTACCAA TGGGTCTTCC ATTCATAAGC CAACCTTGGC ATTCAGAGAA GCCTAGGGAG 
CCAGGCTTGT ACCCTGTAGC GGGTTCTAGA GGTGGGTGGG TTGGTTCTGT CTGGAGTCTA 
GATAAGTTGC TGGCTGGACC AGGTTCTACA AAAGGCAATG GGTCTCTAAG GCAAAGTAAG 
TTCCTGTTTC AACATGGGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136204.1
CDS	328..1191
Translation	MGRLRNAKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIGKGTPIPGLAPSCCLSHRGKEQASPCGLCNPSPFLLPMGLPFISQPWHSEKPREPGLYPVAGSRGGWVGSVWSLDKLLAGPGSTKGNGSLRQSKFLFQHGF

Target ORF information:

RefSeq Version	NM_001142732.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142732.1

ORF Insert Sequence:

ATGGGCCGAC TCAGAAACGC CAAAATCCAC GTAGAGAGAG CCGTCAAGCA GAAGAAGATC 
TTTATGATTC ATGGCCGATA CCCAGTGATC CGGTGTCTCT TGCGTCAGAG GGGCTGGGTA 
GAGAAGAAGA TGGTGCATCC CCCAGGCACA GCCCTGCCAG CACCCCAGAA GGATCTCGAT 
AGCTCCATGC TGGGTGATAG CGATGCCACG GAGGATGAGG ATGAGGAAGA GAACGAAATG 
TTTCGGGAGT CGCAGCTGTT GGACTTGGAT GGTTTCCTGG AATTTGATGA CCTAGATGGG 
ATACATGCTT TGATGTCCCG CATGGTTCGA AATGAGACCC CCTACCTCAT CTGGACCACT 
CGGCGGGATG TGCTGGATTG TCGCTTCCTT TCCAAGGATC AGATGATAAA CCATTATGCC 
CGTGCAGGCT CCTTCACCAC AAAGGTGGGC CTTTGTCTCA ACCTCCGGAA TCTGCCGTGG 
TTTGATGAGG CCGATGCTGA CTCTTTCTTC CCACGATGCT ACCGATTGGG GGCAGAGGAT 
GACAAGAAAG CCTTCATAGG TAAGGGGACT CCAATCCCAG GCCTGGCTCC CTCATGCTGT 
CTGTCCCACA GGGGAAAAGA GCAAGCCTCC CCTTGTGGCC TCTGTAACCC CAGCCCTTTC 
CTCCTACCAA TGGGTCTTCC ATTCATAAGC CAACCTTGGC ATTCAGAGAA GCCTAGGGAG 
CCAGGCTTGT ACCCTGTAGC GGGTTCTAGA GGTGGGTGGG TTGGTTCTGT CTGGAGTCTA 
GATAAGTTGC TGGCTGGACC AGGTTCTACA AAAGGCAATG GGTCTCTAAG GCAAAGTAAG 
TTCCTGTTTC AACATGGGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ttll3 ( NM_133923.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598684.4 Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13201
Clone ID Related Accession (Same CDS sequence)	NM_133923.6 , NM_133923.7
Accession Version	NM_133923.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2784bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550505600000
Organism	Mus musculus(house mouse)
Product	tubulin monoglycylase TTLL3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AM690746.1, AK080321.1 and AA285487.1. On Dec 22, 2008 this sequence version replaced NM_133923.5. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AM690746.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCAGGGTG TCAGCTCGGC GCTTCTCCTG AGCGCGGGGC AGCTGGGGCC CGGGGCCGCC 
TGGTACCGCC AGGAGGGCAG CTCCGAGTGT AGCTGGCTCC GGAGGTCGCA GCCATCCGAG 
CTCCGCACCA ATTTCTCGTC CCGCTGGCCC TGGCCGCGCA ACTCCGAGTC CCGGCGGTCT 
GAGAGGCTAC AATGGCCTGG TCCCGCCTCC GCCAAGCCGG AGGTGGCGAG CTGTGGCGAC 
AGCCGTCGGG ATTACAGCTC ATTGCCTGCG CGCCACCTAA GCAGCGCTCG CGAGTCGTCC 
ATGCCCGGTG CTCTGGGCAC TGTGAACCCC CAACCCGTCC GCACCCTGGT CCCCCCGACC 
CTGGATGAGC CCCTTCCTGA TGCCCTACGG CCGCCTGATG ATTCCCTACT CCTCTGGCGA 
GGACTCACCA AGGGACCTAA CCACATGGGC CGACTCAGAA ACGCCAAAAT CCACGTAGAG 
AGAGCCGTCA AGCAGAAGAA GATCTTTATG ATTCATGGCC GATACCCAGT GATCCGGTGT 
CTCTTGCGTC AGAGGGGCTG GGTAGAGAAG AAGATGGTGC ATCCCCCAGG CACAGCCCTG 
CCAGCACCCC AGAAGGATCT CGATAGCTCC ATGCTGGGTG ATAGCGATGC CACGGAGGAT 
GAGGATGAGG AAGAGAACGA AATGTTTCGG GAGTCGCAGC TGTTGGACTT GGATGGTTTC 
CTGGAATTTG ATGACCTAGA TGGGATACAT GCTTTGATGT CCCGCATGGT TCGAAATGAG 
ACCCCCTACC TCATCTGGAC CACTCGGCGG GATGTGCTGG ATTGTCGCTT CCTTTCCAAG 
GATCAGATGA TAAACCATTA TGCCCGTGCA GGCTCCTTCA CCACAAAGGT GGGCCTTTGT 
CTCAACCTCC GGAATCTGCC GTGGTTTGAT GAGGCCGATG CTGACTCTTT CTTCCCACGA 
TGCTACCGAT TGGGGGCAGA GGATGACAAG AAAGCCTTCA TAGAGGACTT CTGGCTGACA 
GCTGCCCGCA ACGTCCTCAA GCTGGTGGTG AAGTTGGAAG AGAAGTCACA GTCCATCTCC 
ATCCAGGCAA GAGAGGAAGA GGCCCCAGAA GATACACAGC CCAAGAAACA GGAAAAGAAG 
CTAGTGACCG TGTCCTCAGA CTTTGTCGAT GAGGCTCTGA GTGCATGCCA GGAGCACCTT 
AGCAGCATAG CCCACAAAGA CATTGACAAG GACCCCAACT CCCCGCTCTA CCTCAGCCCC 
GATGATTGGT CCCAGTTCCT TCAGCGCTAC TACCAAATAG TTCATGAAGG GGCAGAGCTC 
AGATACCTGG AGGTCCAAGT CCAGCGCTGT GAAGACATCC TACAGCAGCT TCAGAACGTG 
GTACCCCAGT TAGACATGGA GGGGGATCGG AACATCTGGA TCGTGAAGCC CGGAGCCAAG 
TCCCGAGGCC GAGGGATTAT GTGCATGAAC CGCCTGGATG AGATGCTGAA GCTGGTGGAC 
TGCAACCCCA TGCTCATGAA GGATGGCAAG TGGATCGTGC AGAAGTACAT TGAGCGGCCC 
CTGCTTATCT TCGGCACCAA GTTTGACCTG AGACAGTGGT TCCTGGTGAC TGACTGGAAC 
CCACTCACCG TGTGGTTCTA CCGAGACAGC TACATTCGCT TCTCCACACA GCCCTTCTCC 
CTGAAGAACC TGGACAACTC TGTGCACCTG TGTAACAACT CCATCCAGAG ACACTTGGAG 
GCTTCCTGTC ACCGGCACCC GATGCTGCCC CCAGATAACA TGTGGTCCAG CCAGAGGTTT 
CAGGCCCACT TGCAGGAGGT AGATGCCCCA AAGGCCTGGT CCAGCGTCAT CGTGCCAGGC 
ATGAAGGCTG CTGTGATCCA TGCCCTGCAG ACCTCCCAAG ATAACGTGCA GTGCCGGAAG 
GCCAGCTTTG AGCTCTATGG GGCAGACTTT GTGTTTGGGG AAGACTTCCA GCCCTGGTTG 
ATTGAAATCA ATGCCAGCCC CACCATGGCA CCTTCCACGG CTGTCACTGC CCGCCTCTGT 
GCCGGTGTGC AGGCAGATAC CCTGCGTGTG GTCATCGACC GGCGCCTGGA CCGCAGCTGT 
GATACGGGAG CCTTTGAGCT CATCTATAAG CAGCCTGCTG TGGAGGTGCC TCAGTACGTG 
GGTATCCGGC TCCTAGTGGA GGGCTCTACC ATCAAGAAGC CCGTGCCCGT GGGTCATCGG 
CGGACAGGGG TCCGCTCATC ACTCCCTCAT CTGCTGACCC AGCAAGGCTC TGGGGAAAGC 
AAGGACTCAG GCTCCCCTAC CCACAGGTCA GCTTCTAGGA AAAATGCTAG GGCCGAGAGC 
CTGGAGCACA CCGAGAAGCC GGAACCTGCG GCCGTCGCCT CTGTCTCCGG AAAGGGGAAG 
AAAGCCCCTT TCCACTTCCC TAGCCTCCAT TCCAAGGCCT GGCTGCCTTC TCCCCGTGTG 
CACCGACCCC AGGGCCGGGT CCTCAGACTC CAACATGACC AGCTGGTGGG CTCTAAGGCT 
CTGTCAACCA CAGGCAAGGC CTTGATGACT CTTCCTACTG CCAAGGTTCT GATGTCCTTC 
CCACCTCACC CTGATCTCAA GCTGGCACCT AGCATGCTGA AACCAGGAAA GGTGGGCTTC 
GAGCTGTGCT GCACAACCTG GCGGGTAGTG CTGAGTGGTG GGATCGGGGA AGAAGGGCAC 
AGACAGAGGG CAGCACCCAG ACCAAGCAGC GCACCAGGGA AGGGCTTATC TTCCACAGAA 
CCCTGTTCCA AGACAGAGAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598684.4
CDS	1..2784
Translation	MQGVSSALLLSAGQLGPGAAWYRQEGSSECSWLRRSQPSELRTNFSSRWPWPRNSESRRSERLQWPGPASAKPEVASCGDSRRDYSSLPARHLSSARESSMPGALGTVNPQPVRTLVPPTLDEPLPDALRPPDDSLLLWRGLTKGPNHMGRLRNAKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIEDFWLTAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFVDEALSACQEHLSSIAHKDIDKDPNSPLYLSPDDWSQFLQRYYQIVHEGAELRYLEVQVQRCEDILQQLQNVVPQLDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWIVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQRHLEASCHRHPMLPPDNMWSSQRFQAHLQEVDAPKAWSSVIVPGMKAAVIHALQTSQDNVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGAFELIYKQPAVEVPQYVGIRLLVEGSTIKKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHRSASRKNARAESLEHTEKPEPAAVASVSGKGKKAPFHFPSLHSKAWLPSPRVHRPQGRVLRLQHDQLVGSKALSTTGKALMTLPTAKVLMSFPPHPDLKLAPSMLKPGKVGFELCCTTWRVVLSGGIGEEGHRQRAAPRPSSAPGKGLSSTEPCSKTET

Target ORF information:

RefSeq Version	NM_133923.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133923.6

ORF Insert Sequence:

ATGCAGGGTG TCAGCTCGGC GCTTCTCCTG AGCGCGGGGC AGCTGGGGCC CGGGGCCGCC 
TGGTACCGCC AGGAGGGCAG CTCCGAGTGT AGCTGGCTCC GGAGGTCGCA GCCATCCGAG 
CTCCGCACCA ATTTCTCGTC CCGCTGGCCC TGGCCGCGCA ACTCCGAGTC CCGGCGGTCT 
GAGAGGCTAC AATGGCCTGG TCCCGCCTCC GCCAAGCCGG AGGTGGCGAG CTGTGGCGAC 
AGCCGTCGGG ATTACAGCTC ATTGCCTGCG CGCCACCTAA GCAGCGCTCG CGAGTCGTCC 
ATGCCCGGTG CTCTGGGCAC TGTGAACCCC CAACCCGTCC GCACCCTGGT CCCCCCGACC 
CTGGATGAGC CCCTTCCTGA TGCCCTACGG CCGCCTGATG ATTCCCTACT CCTCTGGCGA 
GGACTCACCA AGGGACCTAA CCACATGGGC CGACTCAGAA ACGCCAAAAT CCACGTAGAG 
AGAGCCGTCA AGCAGAAGAA GATCTTTATG ATTCATGGCC GATACCCAGT GATCCGGTGT 
CTCTTGCGTC AGAGGGGCTG GGTAGAGAAG AAGATGGTGC ATCCCCCAGG CACAGCCCTG 
CCAGCACCCC AGAAGGATCT CGATAGCTCC ATGCTGGGTG ATAGCGATGC CACGGAGGAT 
GAGGATGAGG AAGAGAACGA AATGTTTCGG GAGTCGCAGC TGTTGGACTT GGATGGTTTC 
CTGGAATTTG ATGACCTAGA TGGGATACAT GCTTTGATGT CCCGCATGGT TCGAAATGAG 
ACCCCCTACC TCATCTGGAC CACTCGGCGG GATGTGCTGG ATTGTCGCTT CCTTTCCAAG 
GATCAGATGA TAAACCATTA TGCCCGTGCA GGCTCCTTCA CCACAAAGGT GGGCCTTTGT 
CTCAACCTCC GGAATCTGCC GTGGTTTGAT GAGGCCGATG CTGACTCTTT CTTCCCACGA 
TGCTACCGAT TGGGGGCAGA GGATGACAAG AAAGCCTTCA TAGAGGACTT CTGGCTGACA 
GCTGCCCGCA ACGTCCTCAA GCTGGTGGTG AAGTTGGAAG AGAAGTCACA GTCCATCTCC 
ATCCAGGCAA GAGAGGAAGA GGCCCCAGAA GATACACAGC CCAAGAAACA GGAAAAGAAG 
CTAGTGACCG TGTCCTCAGA CTTTGTCGAT GAGGCTCTGA GTGCATGCCA GGAGCACCTT 
AGCAGCATAG CCCACAAAGA CATTGACAAG GACCCCAACT CCCCGCTCTA CCTCAGCCCC 
GATGATTGGT CCCAGTTCCT TCAGCGCTAC TACCAAATAG TTCATGAAGG GGCAGAGCTC 
AGATACCTGG AGGTCCAAGT CCAGCGCTGT GAAGACATCC TACAGCAGCT TCAGAACGTG 
GTACCCCAGT TAGACATGGA GGGGGATCGG AACATCTGGA TCGTGAAGCC CGGAGCCAAG 
TCCCGAGGCC GAGGGATTAT GTGCATGAAC CGCCTGGATG AGATGCTGAA GCTGGTGGAC 
TGCAACCCCA TGCTCATGAA GGATGGCAAG TGGATCGTGC AGAAGTACAT TGAGCGGCCC 
CTGCTTATCT TCGGCACCAA GTTTGACCTG AGACAGTGGT TCCTGGTGAC TGACTGGAAC 
CCACTCACCG TGTGGTTCTA CCGAGACAGC TACATTCGCT TCTCCACACA GCCCTTCTCC 
CTGAAGAACC TGGACAACTC TGTGCACCTG TGTAACAACT CCATCCAGAG ACACTTGGAG 
GCTTCCTGTC ACCGGCACCC GATGCTGCCC CCAGATAACA TGTGGTCCAG CCAGAGGTTT 
CAGGCCCACT TGCAGGAGGT AGATGCCCCA AAGGCCTGGT CCAGCGTCAT CGTGCCAGGC 
ATGAAGGCTG CTGTGATCCA TGCCCTGCAG ACCTCCCAAG ATAACGTGCA GTGCCGGAAG 
GCCAGCTTTG AGCTCTATGG GGCAGACTTT GTGTTTGGGG AAGACTTCCA GCCCTGGTTG 
ATTGAAATCA ATGCCAGCCC CACCATGGCA CCTTCCACGG CTGTCACTGC CCGCCTCTGT 
GCCGGTGTGC AGGCAGATAC CCTGCGTGTG GTCATCGACC GGCGCCTGGA CCGCAGCTGT 
GATACGGGAG CCTTTGAGCT CATCTATAAG CAGCCTGCTG TGGAGGTGCC TCAGTACGTG 
GGTATCCGGC TCCTAGTGGA GGGCTCTACC ATCAAGAAGC CCGTGCCCGT GGGTCATCGG 
CGGACAGGGG TCCGCTCATC ACTCCCTCAT CTGCTGACCC AGCAAGGCTC TGGGGAAAGC 
AAGGACTCAG GCTCCCCTAC CCACAGGTCA GCTTCTAGGA AAAATGCTAG GGCCGAGAGC 
CTGGAGCACA CCGAGAAGCC GGAACCTGCG GCCGTCGCCT CTGTCTCCGG AAAGGGGAAG 
AAAGCCCCTT TCCACTTCCC TAGCCTCCAT TCCAAGGCCT GGCTGCCTTC TCCCCGTGTG 
CACCGACCCC AGGGCCGGGT CCTCAGACTC CAACATGACC AGCTGGTGGG CTCTAAGGCT 
CTGTCAACCA CAGGCAAGGC CTTGATGACT CTTCCTACTG CCAAGGTTCT GATGTCCTTC 
CCACCTCACC CTGATCTCAA GCTGGCACCT AGCATGCTGA AACCAGGAAA GGTGGGCTTC 
GAGCTGTGCT GCACAACCTG GCGGGTAGTG CTGAGTGGTG GGATCGGGGA AGAAGGGCAC 
AGACAGAGGG CAGCACCCAG ACCAAGCAGC GCACCAGGGA AGGGCTTATC TTCCACAGAA 
CCCTGTTCCA AGACAGAGAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ttll3 ( NM_133923.7 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598684.4 Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13201
Clone ID Related Accession (Same CDS sequence)	NM_133923.6 , NM_133923.7
Accession Version	NM_133923.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2784bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1560787200000
Organism	Mus musculus(house mouse)
Product	tubulin monoglycylase TTLL3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC153910.6, AM690746.1, AK080321.1 and AA285487.1. On Jun 19, 2019 this sequence version replaced NM_133923.6. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AM690746.1, SRR7652917.547091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCAGGGTG TCAGCTCGGC GCTTCTCCTG AGCGCGGGGC AGCTGGGGCC CGGGGCCGCC 
TGGTACCGCC AGGAGGGCAG CTCCGAGTGT AGCTGGCTCC GGAGGTCGCA GCCATCCGAG 
CTCCGCACCA ATTTCTCGTC CCGCTGGCCC TGGCCGCGCA ACTCCGAGTC CCGGCGGTCT 
GAGAGGCTAC AATGGCCTGG TCCCGCCTCC GCCAAGCCGG AGGTGGCGAG CTGTGGCGAC 
AGCCGTCGGG ATTACAGCTC ATTGCCTGCG CGCCACCTAA GCAGCGCTCG CGAGTCGTCC 
ATGCCCGGTG CTCTGGGCAC TGTGAACCCC CAACCCGTCC GCACCCTGGT CCCCCCGACC 
CTGGATGAGC CCCTTCCTGA TGCCCTACGG CCGCCTGATG ATTCCCTACT CCTCTGGCGA 
GGACTCACCA AGGGACCTAA CCACATGGGC CGACTCAGAA ACGCCAAAAT CCACGTAGAG 
AGAGCCGTCA AGCAGAAGAA GATCTTTATG ATTCATGGCC GATACCCAGT GATCCGGTGT 
CTCTTGCGTC AGAGGGGCTG GGTAGAGAAG AAGATGGTGC ATCCCCCAGG CACAGCCCTG 
CCAGCACCCC AGAAGGATCT CGATAGCTCC ATGCTGGGTG ATAGCGATGC CACGGAGGAT 
GAGGATGAGG AAGAGAACGA AATGTTTCGG GAGTCGCAGC TGTTGGACTT GGATGGTTTC 
CTGGAATTTG ATGACCTAGA TGGGATACAT GCTTTGATGT CCCGCATGGT TCGAAATGAG 
ACCCCCTACC TCATCTGGAC CACTCGGCGG GATGTGCTGG ATTGTCGCTT CCTTTCCAAG 
GATCAGATGA TAAACCATTA TGCCCGTGCA GGCTCCTTCA CCACAAAGGT GGGCCTTTGT 
CTCAACCTCC GGAATCTGCC GTGGTTTGAT GAGGCCGATG CTGACTCTTT CTTCCCACGA 
TGCTACCGAT TGGGGGCAGA GGATGACAAG AAAGCCTTCA TAGAGGACTT CTGGCTGACA 
GCTGCCCGCA ACGTCCTCAA GCTGGTGGTG AAGTTGGAAG AGAAGTCACA GTCCATCTCC 
ATCCAGGCAA GAGAGGAAGA GGCCCCAGAA GATACACAGC CCAAGAAACA GGAAAAGAAG 
CTAGTGACCG TGTCCTCAGA CTTTGTCGAT GAGGCTCTGA GTGCATGCCA GGAGCACCTT 
AGCAGCATAG CCCACAAAGA CATTGACAAG GACCCCAACT CCCCGCTCTA CCTCAGCCCC 
GATGATTGGT CCCAGTTCCT TCAGCGCTAC TACCAAATAG TTCATGAAGG GGCAGAGCTC 
AGATACCTGG AGGTCCAAGT CCAGCGCTGT GAAGACATCC TACAGCAGCT TCAGAACGTG 
GTACCCCAGT TAGACATGGA GGGGGATCGG AACATCTGGA TCGTGAAGCC CGGAGCCAAG 
TCCCGAGGCC GAGGGATTAT GTGCATGAAC CGCCTGGATG AGATGCTGAA GCTGGTGGAC 
TGCAACCCCA TGCTCATGAA GGATGGCAAG TGGATCGTGC AGAAGTACAT TGAGCGGCCC 
CTGCTTATCT TCGGCACCAA GTTTGACCTG AGACAGTGGT TCCTGGTGAC TGACTGGAAC 
CCACTCACCG TGTGGTTCTA CCGAGACAGC TACATTCGCT TCTCCACACA GCCCTTCTCC 
CTGAAGAACC TGGACAACTC TGTGCACCTG TGTAACAACT CCATCCAGAG ACACTTGGAG 
GCTTCCTGTC ACCGGCACCC GATGCTGCCC CCAGATAACA TGTGGTCCAG CCAGAGGTTT 
CAGGCCCACT TGCAGGAGGT AGATGCCCCA AAGGCCTGGT CCAGCGTCAT CGTGCCAGGC 
ATGAAGGCTG CTGTGATCCA TGCCCTGCAG ACCTCCCAAG ATAACGTGCA GTGCCGGAAG 
GCCAGCTTTG AGCTCTATGG GGCAGACTTT GTGTTTGGGG AAGACTTCCA GCCCTGGTTG 
ATTGAAATCA ATGCCAGCCC CACCATGGCA CCTTCCACGG CTGTCACTGC CCGCCTCTGT 
GCCGGTGTGC AGGCAGATAC CCTGCGTGTG GTCATCGACC GGCGCCTGGA CCGCAGCTGT 
GATACGGGAG CCTTTGAGCT CATCTATAAG CAGCCTGCTG TGGAGGTGCC TCAGTACGTG 
GGTATCCGGC TCCTAGTGGA GGGCTCTACC ATCAAGAAGC CCGTGCCCGT GGGTCATCGG 
CGGACAGGGG TCCGCTCATC ACTCCCTCAT CTGCTGACCC AGCAAGGCTC TGGGGAAAGC 
AAGGACTCAG GCTCCCCTAC CCACAGGTCA GCTTCTAGGA AAAATGCTAG GGCCGAGAGC 
CTGGAGCACA CCGAGAAGCC GGAACCTGCG GCCGTCGCCT CTGTCTCCGG AAAGGGGAAG 
AAAGCCCCTT TCCACTTCCC TAGCCTCCAT TCCAAGGCCT GGCTGCCTTC TCCCCGTGTG 
CACCGACCCC AGGGCCGGGT CCTCAGACTC CAACATGACC AGCTGGTGGG CTCTAAGGCT 
CTGTCAACCA CAGGCAAGGC CTTGATGACT CTTCCTACTG CCAAGGTTCT GATGTCCTTC 
CCACCTCACC CTGATCTCAA GCTGGCACCT AGCATGCTGA AACCAGGAAA GGTGGGCTTC 
GAGCTGTGCT GCACAACCTG GCGGGTAGTG CTGAGTGGTG GGATCGGGGA AGAAGGGCAC 
AGACAGAGGG CAGCACCCAG ACCAAGCAGC GCACCAGGGA AGGGCTTATC TTCCACAGAA 
CCCTGTTCCA AGACAGAGAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598684.4
CDS	35..2818
Translation	MQGVSSALLLSAGQLGPGAAWYRQEGSSECSWLRRSQPSELRTNFSSRWPWPRNSESRRSERLQWPGPASAKPEVASCGDSRRDYSSLPARHLSSARESSMPGALGTVNPQPVRTLVPPTLDEPLPDALRPPDDSLLLWRGLTKGPNHMGRLRNAKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIEDFWLTAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFVDEALSACQEHLSSIAHKDIDKDPNSPLYLSPDDWSQFLQRYYQIVHEGAELRYLEVQVQRCEDILQQLQNVVPQLDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWIVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQRHLEASCHRHPMLPPDNMWSSQRFQAHLQEVDAPKAWSSVIVPGMKAAVIHALQTSQDNVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGAFELIYKQPAVEVPQYVGIRLLVEGSTIKKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHRSASRKNARAESLEHTEKPEPAAVASVSGKGKKAPFHFPSLHSKAWLPSPRVHRPQGRVLRLQHDQLVGSKALSTTGKALMTLPTAKVLMSFPPHPDLKLAPSMLKPGKVGFELCCTTWRVVLSGGIGEEGHRQRAAPRPSSAPGKGLSSTEPCSKTET

Target ORF information:

RefSeq Version	NM_133923.7
Organism	Mus musculus(house mouse)
Definition	Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133923.7

ORF Insert Sequence:

ATGCAGGGTG TCAGCTCGGC GCTTCTCCTG AGCGCGGGGC AGCTGGGGCC CGGGGCCGCC 
TGGTACCGCC AGGAGGGCAG CTCCGAGTGT AGCTGGCTCC GGAGGTCGCA GCCATCCGAG 
CTCCGCACCA ATTTCTCGTC CCGCTGGCCC TGGCCGCGCA ACTCCGAGTC CCGGCGGTCT 
GAGAGGCTAC AATGGCCTGG TCCCGCCTCC GCCAAGCCGG AGGTGGCGAG CTGTGGCGAC 
AGCCGTCGGG ATTACAGCTC ATTGCCTGCG CGCCACCTAA GCAGCGCTCG CGAGTCGTCC 
ATGCCCGGTG CTCTGGGCAC TGTGAACCCC CAACCCGTCC GCACCCTGGT CCCCCCGACC 
CTGGATGAGC CCCTTCCTGA TGCCCTACGG CCGCCTGATG ATTCCCTACT CCTCTGGCGA 
GGACTCACCA AGGGACCTAA CCACATGGGC CGACTCAGAA ACGCCAAAAT CCACGTAGAG 
AGAGCCGTCA AGCAGAAGAA GATCTTTATG ATTCATGGCC GATACCCAGT GATCCGGTGT 
CTCTTGCGTC AGAGGGGCTG GGTAGAGAAG AAGATGGTGC ATCCCCCAGG CACAGCCCTG 
CCAGCACCCC AGAAGGATCT CGATAGCTCC ATGCTGGGTG ATAGCGATGC CACGGAGGAT 
GAGGATGAGG AAGAGAACGA AATGTTTCGG GAGTCGCAGC TGTTGGACTT GGATGGTTTC 
CTGGAATTTG ATGACCTAGA TGGGATACAT GCTTTGATGT CCCGCATGGT TCGAAATGAG 
ACCCCCTACC TCATCTGGAC CACTCGGCGG GATGTGCTGG ATTGTCGCTT CCTTTCCAAG 
GATCAGATGA TAAACCATTA TGCCCGTGCA GGCTCCTTCA CCACAAAGGT GGGCCTTTGT 
CTCAACCTCC GGAATCTGCC GTGGTTTGAT GAGGCCGATG CTGACTCTTT CTTCCCACGA 
TGCTACCGAT TGGGGGCAGA GGATGACAAG AAAGCCTTCA TAGAGGACTT CTGGCTGACA 
GCTGCCCGCA ACGTCCTCAA GCTGGTGGTG AAGTTGGAAG AGAAGTCACA GTCCATCTCC 
ATCCAGGCAA GAGAGGAAGA GGCCCCAGAA GATACACAGC CCAAGAAACA GGAAAAGAAG 
CTAGTGACCG TGTCCTCAGA CTTTGTCGAT GAGGCTCTGA GTGCATGCCA GGAGCACCTT 
AGCAGCATAG CCCACAAAGA CATTGACAAG GACCCCAACT CCCCGCTCTA CCTCAGCCCC 
GATGATTGGT CCCAGTTCCT TCAGCGCTAC TACCAAATAG TTCATGAAGG GGCAGAGCTC 
AGATACCTGG AGGTCCAAGT CCAGCGCTGT GAAGACATCC TACAGCAGCT TCAGAACGTG 
GTACCCCAGT TAGACATGGA GGGGGATCGG AACATCTGGA TCGTGAAGCC CGGAGCCAAG 
TCCCGAGGCC GAGGGATTAT GTGCATGAAC CGCCTGGATG AGATGCTGAA GCTGGTGGAC 
TGCAACCCCA TGCTCATGAA GGATGGCAAG TGGATCGTGC AGAAGTACAT TGAGCGGCCC 
CTGCTTATCT TCGGCACCAA GTTTGACCTG AGACAGTGGT TCCTGGTGAC TGACTGGAAC 
CCACTCACCG TGTGGTTCTA CCGAGACAGC TACATTCGCT TCTCCACACA GCCCTTCTCC 
CTGAAGAACC TGGACAACTC TGTGCACCTG TGTAACAACT CCATCCAGAG ACACTTGGAG 
GCTTCCTGTC ACCGGCACCC GATGCTGCCC CCAGATAACA TGTGGTCCAG CCAGAGGTTT 
CAGGCCCACT TGCAGGAGGT AGATGCCCCA AAGGCCTGGT CCAGCGTCAT CGTGCCAGGC 
ATGAAGGCTG CTGTGATCCA TGCCCTGCAG ACCTCCCAAG ATAACGTGCA GTGCCGGAAG 
GCCAGCTTTG AGCTCTATGG GGCAGACTTT GTGTTTGGGG AAGACTTCCA GCCCTGGTTG 
ATTGAAATCA ATGCCAGCCC CACCATGGCA CCTTCCACGG CTGTCACTGC CCGCCTCTGT 
GCCGGTGTGC AGGCAGATAC CCTGCGTGTG GTCATCGACC GGCGCCTGGA CCGCAGCTGT 
GATACGGGAG CCTTTGAGCT CATCTATAAG CAGCCTGCTG TGGAGGTGCC TCAGTACGTG 
GGTATCCGGC TCCTAGTGGA GGGCTCTACC ATCAAGAAGC CCGTGCCCGT GGGTCATCGG 
CGGACAGGGG TCCGCTCATC ACTCCCTCAT CTGCTGACCC AGCAAGGCTC TGGGGAAAGC 
AAGGACTCAG GCTCCCCTAC CCACAGGTCA GCTTCTAGGA AAAATGCTAG GGCCGAGAGC 
CTGGAGCACA CCGAGAAGCC GGAACCTGCG GCCGTCGCCT CTGTCTCCGG AAAGGGGAAG 
AAAGCCCCTT TCCACTTCCC TAGCCTCCAT TCCAAGGCCT GGCTGCCTTC TCCCCGTGTG 
CACCGACCCC AGGGCCGGGT CCTCAGACTC CAACATGACC AGCTGGTGGG CTCTAAGGCT 
CTGTCAACCA CAGGCAAGGC CTTGATGACT CTTCCTACTG CCAAGGTTCT GATGTCCTTC 
CCACCTCACC CTGATCTCAA GCTGGCACCT AGCATGCTGA AACCAGGAAA GGTGGGCTTC 
GAGCTGTGCT GCACAACCTG GCGGGTAGTG CTGAGTGGTG GGATCGGGGA AGAAGGGCAC 
AGACAGAGGG CAGCACCCAG ACCAAGCAGC GCACCAGGGA AGGGCTTATC TTCCACAGAA 
CCCTGTTCCA AGACAGAGAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration.
Journal of cell science130(5)938-949(2017 03)
Bosch Grau M,Masson C,Gadadhar S,Rocha C,Tort O,Marques Sousa P,Vacher S,Bieche I,Janke C

Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.
The EMBO journal33(19)2247-60(2014 Oct)
Rocha C,Papon L,Cacheux W,Marques Sousa P,Lascano V,Tort O,Giordano T,Vacher S,Lemmers B,Mariani P,Meseure D,Medema JP,Bièche I,Hahne M,Janke C

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Disease models & mechanisms7(5)515-24(2014 May)
Adissu HA,Estabel J,Sunter D,Tuck E,Hooks Y,Carragher DM,Clarke K,Karp NA,,Newbigging S,Jones N,Morikawa L,White JK,McKerlie C

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.
The Journal of cell biology202(3)441-51(2013 Aug)
Bosch Grau M,Gonzalez Curto G,Rocha C,Magiera MM,Marques Sousa P,Giordano T,Spassky N,Janke C

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.
Cell137(6)1076-87(2009 Jun)
Rogowski K,Juge F,van Dijk J,Wloga D,Strub JM,Levilliers N,Thomas D,Bré MH,Van Dorsselaer A,Gaertig J,Janke C

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Ttll3 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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