IRF2BPL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IRF2BPL
Entrez Gene ID	64207
Full Name	interferon regulatory factor 2 binding protein like
Synonyms	C14orf4,EAP1
General protein information	Preferred Names interferon regulatory factor 2 binding protein like Names interferon regulatory factor 2-binding protein-like enhanced at puberty 1 enhanced at puberty protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q24.3
Summary	This gene encodes a transcription factor that may play a role in regulating female reproductive function. [provided by RefSeq, Jun 2012].
Disorder MIM:	611720

mRNA and Protein(s)

mRNA	Protein	Name
NM_024496.3	NP_078772.1	interferon regulatory factor 2-binding protein-like
NM_024496.4	NP_078772.1	probable E3 ubiquitin-protein ligase IRF2BPL

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IRF2BPL	XP_002691170.1
Mus musculus (house mouse)	Irf2bpl	NP_665835.1
Danio rerio (zebrafish)	irf2bpl	NP_997852.1
Homo sapiens (human)	IRF2BPL	NP_078772.1
Pan troglodytes (chimpanzee)	IRF2BPL	XP_510088.3
Macaca mulatta (Rhesus monkey)	IRF2BPL	NP_001040589.1
Rattus norvegicus (Norway rat)	Irf2bpl	NP_001012488.1
Canis lupus familiaris (dog)	IRF2BPL	XP_005623753.1
Gallus gallus (chicken)	C14ORF4	XP_426978.4
Xenopus tropicalis (tropical clawed frog)	irf2bpl	NP_001123823.1

Gene Ontology
Bibliography

Related articles in PubMed

De novo truncating variants in the intronless IRF2BPL are responsible for developmental epileptic encephalopathy.
Tran Mau-Them F, Guibaud L, Duplomb L, Keren B, Lindstrom K, Marey I, Mochel F, van den Boogaard MJ, Oegema R, Nava C, Masurel A, Jouan T, Jansen FE, Au M, Chen AH, Cho M, Duffourd Y, Lozier E, Konovalov F, Sharkov A, Korostelev S, Urteaga B, Dickson P, Vera M, Martínez-Agosto JA, Begemann A, Zweier M, Schmitt-Mechelke T, Rauch A, Philippe C, van Gassen K, Nelson S, Graham JM Jr, Friedman J, Faivre L, Lin HJ, Thauvin-Robinet C, Vitobello A
Genetics in medicine : official journal of the American College of Medical Genetics21(4)1008-1014(2019 04)

IRF2BPL Is Associated with Neurological Phenotypes.
Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM Jr, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K, , , Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM
American journal of human genetics103(2)245-260(2018 08)

Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis.
Higashimori A, Dong Y, Zhang Y, Kang W, Nakatsu G, Ng SSM, Arakawa T, Sung JJY, Chan FKL, Yu J
Cancer research78(7)1643-1656(2018 04)

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
Böhm D, Keller K, Pieter J, Boehm N, Wolters D, Siggelkow W, Lebrecht A, Schmidt M, Kölbl H, Pfeiffer N, Grus FH
Oncology reports28(2)429-38(2012 Aug)

Hypothalamic expression of Eap1 is not directly controlled by ovarian steroids.
Matagne V, Mastronardi C, Shapiro RA, Dorsa DM, Ojeda SR
Endocrinology150(4)1870-8(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IRF2BPL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IRF2BPL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11949	NM_024496.4 Latest version!	Homo sapiens interferon regulatory factor 2 binding protein like (IRF2BPL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OHu11949	NM_024496.3	Homo sapiens interferon regulatory factor 2 binding protein like (IRF2BPL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IRF2BPL ( NM_024496.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_078772.1 Homo sapiens interferon regulatory factor 2 binding protein like (IRF2BPL), mRNA.

Price & Availability↑

CloneID	OHu11949
Clone ID Related Accession (Same CDS sequence)	NM_024496.3 , NM_024496.4
Accession Version	NM_024496.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2391bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	interferon regulatory factor 2-binding protein-like
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC108292.1 and AC007686.5. On Jun 8, 2012 this sequence version replaced NM_024496.2. ##Evidence-Data-START## Transcript is intronless :: BC108292.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCGGCGG CGCAGGTGTC CTCGTCCCGG AGACAATCTT GCTACCTGTG CGACCTGCCC 
CGCATGCCCT GGGCCATGAT CTGGGACTTC TCGGAACCCG TATGCCGCGG TTGCGTCAAC 
TACGAGGGCG CTGATCGCAT CGAATTCGTG ATCGAGACAG CGCGCCAGCT GAAGCGGGCG 
CACGGCTGCT TCCAGGACGG CCGCTCCCCC GGGCCGCCGC CGCCCGTCGG GGTCAAGACA 
GTGGCCCTGT CGGCTAAGGA AGCGGCGGCG GCGGCGGCAG CAGCGGCGGC CGCCGCCGCC 
GCCGCGCAAC AGCAACAGCA ACAGCAGCAG CAGCAGCAGC AACAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAACAACA GCTCAACCAC GTTGATGGTT CCAGCAAGCC TGCGGTGCTG 
GCGGCCCCGT CTGGCCTGGA GCGCTACGGC CTAAGCGCTG CCGCCGCCGC CGCCGCCGCC 
GCCGCCGCTG CGGTGGAACA GCGCAGCCGC TTCGAGTACC CGCCACCGCC GGTGAGCCTG 
GGAAGCAGCA GCCACACCGC GCGACTGCCC AACGGCCTGG GGGGCCCAAA CGGCTTCCCC 
AAACCAACAC CAGAGGAGGG ACCCCCAGAG CTGAACCGTC AGAGCCCCAA TTCTTCTTCA 
GCGGCGGCGT CGGTGGCGTC TCGGCGTGGA ACGCACGGTG GGCTGGTTAC GGGGCTGCCC 
AACCCGGGGG GTGGCGGAGG CCCCCAGCTC ACCGTGCCCC CCAACCTGCT ACCGCAGACG 
CTGCTTAACG GCCCGGCCAG CGCTGCGGTA CTCCCCCCAC CCCCTCCCCA CGCCCTGGGC 
AGCCGTGGGC CCCCGACGCC TGCTCCCCCA GGGGCTCCTG GGGGCCCCGC TTGTCTCGGG 
GGTACCCCGG GTGTATCGGC CACGTCGTCC TCCGCGTCGT CTTCGACCTC TTCGTCGGTG 
GCAGAGGTGG GCGTGGGTGC TGGTGGTAAG AGGCCCGGCT CGGTGTCGAG CACAGACCAG 
GAGCGCGAGT TGAAGGAGAA GCAGCGCAAC GCCGAGGCCC TGGCCGAGCT GAGCGAGAGC 
CTGCGCAACC GCGCCGAGGA GTGGGCCAGC AAGCCCAAGA TGGTCCGCGA CACGCTGCTC 
ACGCTGGCAG GCTGCACGCC CTACGAGGTT CGCTTCAAGA AGGACCACTC GCTGCTGGGC 
CGCGTTTTCG CCTTCGACGC CGTCTCCAAG CCCGGCATGG ACTACGAATT GAAGCTGTTC 
ATTGAGTACC CCACGGGCTC GGGCAACGTG TACTCCAGTG CATCTGGTGT GGCCAAGCAG 
ATGTATCAGG ACTGCATGAA GGACTTCGGC CGGGGCCTAT CCTCGGGTTT CAAGTACCTG 
GAGTACGAAA AGAAGCACGG CTCCGGGGAC TGGCGCCTGC TTGGAGACCT GCTCCCCGAA 
GCCGTGCGCT TCTTCAAGGA GGGCGTGCCC GGCGCCGACA TGCTGCCCCA GCCCTACCTG 
GACGCCAGCT GTCCCATGCT GCCCACTGCT CTGGTGAGTC TGAGCCGCGC CCCCAGCGCA 
CCCCCGGGGA CCGGGGCCTT GCCGCCCGCC GCGCCGTCGG GCCGGGGCGC AGCCGCCAGC 
CTGCGCAAGA GAAAGGCCTC TCCGGAGCCC CCGGACTCAG CCGAGGGCGC GCTGAAGCTG 
GGCGAGGAAC AGCAGAGGCA GCAGTGGATG GCGAACCAGA GCGAGGCGCT GAAGCTCACC 
ATGTCCGCCG GGGGCTTCGC GGCGCCGGGG CACGCGGCGG GGGGTCCGCC TCCGCCGCCC 
CCACCTCTGG GACCCCATTC CAACCGGACC ACCCCACCTG AGTCAGCCCC CCAGAACGGT 
CCGTCCCCTA TGGCCGCTCT CATGTCGGTG GCAGATACTC TGGGCACAGC GCACTCGCCC 
AAGGATGGCA GTTCCGTGCA CTCTACCACT GCGTCGGCGC GGCGAAACAG CAGCAGCCCA 
GTCTCGCCGG CCTCCGTGCC GGGGCAGCGC CGCTTGGCAT CACGTAACGG GGACCTGAAT 
TTACAGGTGG CGCCCCCGCC GCCTAGCGCC CACCCGGGCA TGGACCAAGT GCACCCCCAA 
AACATTCCGG ATTCCCCCAT GGCCAACAGC GGACCCCTCT GCTGCACCAT TTGCCACGAA 
CGTTTGGAGG ATACGCATTT CGTTCAGTGC CCTTCCGTCC CCAGCCACAA ATTTTGCTTC 
CCTTGCTCTA GAGAGAGTAT CAAGGCCCAG GGGGCCACCG GCGAGGTGTA TTGCCCCAGC 
GGAGAGAAAT GCCCCCTAGT CGGGTCGAAT GTACCTTGGG CCTTCATGCA GGGCGAAATC 
GCGACTATCT TAGCTGGGGA TGTTAAAGTG AAAAAGGAGA GAGACCCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078772.1
CDS	908..3298
Translation	MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRAHGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQQQQQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSLGSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLPNPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACLGGTPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSESLRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAAASLRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPPPPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSPVSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDP

Target ORF information:

RefSeq Version	NM_024496.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon regulatory factor 2 binding protein like (IRF2BPL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024496.3

ORF Insert Sequence:

ATGTCGGCGG CGCAGGTGTC CTCGTCCCGG AGACAATCTT GCTACCTGTG CGACCTGCCC 
CGCATGCCCT GGGCCATGAT CTGGGACTTC TCGGAACCCG TATGCCGCGG TTGCGTCAAC 
TACGAGGGCG CTGATCGCAT CGAATTCGTG ATCGAGACAG CGCGCCAGCT GAAGCGGGCG 
CACGGCTGCT TCCAGGACGG CCGCTCCCCC GGGCCGCCGC CGCCCGTCGG GGTCAAGACA 
GTGGCCCTGT CGGCTAAGGA AGCGGCGGCG GCGGCGGCAG CAGCGGCGGC CGCCGCCGCC 
GCCGCGCAAC AGCAACAGCA ACAGCAGCAG CAGCAGCAGC AACAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAACAACA GCTCAACCAC GTTGATGGTT CCAGCAAGCC TGCGGTGCTG 
GCGGCCCCGT CTGGCCTGGA GCGCTACGGC CTAAGCGCTG CCGCCGCCGC CGCCGCCGCC 
GCCGCCGCTG CGGTGGAACA GCGCAGCCGC TTCGAGTACC CGCCACCGCC GGTGAGCCTG 
GGAAGCAGCA GCCACACCGC GCGACTGCCC AACGGCCTGG GGGGCCCAAA CGGCTTCCCC 
AAACCAACAC CAGAGGAGGG ACCCCCAGAG CTGAACCGTC AGAGCCCCAA TTCTTCTTCA 
GCGGCGGCGT CGGTGGCGTC TCGGCGTGGA ACGCACGGTG GGCTGGTTAC GGGGCTGCCC 
AACCCGGGGG GTGGCGGAGG CCCCCAGCTC ACCGTGCCCC CCAACCTGCT ACCGCAGACG 
CTGCTTAACG GCCCGGCCAG CGCTGCGGTA CTCCCCCCAC CCCCTCCCCA CGCCCTGGGC 
AGCCGTGGGC CCCCGACGCC TGCTCCCCCA GGGGCTCCTG GGGGCCCCGC TTGTCTCGGG 
GGTACCCCGG GTGTATCGGC CACGTCGTCC TCCGCGTCGT CTTCGACCTC TTCGTCGGTG 
GCAGAGGTGG GCGTGGGTGC TGGTGGTAAG AGGCCCGGCT CGGTGTCGAG CACAGACCAG 
GAGCGCGAGT TGAAGGAGAA GCAGCGCAAC GCCGAGGCCC TGGCCGAGCT GAGCGAGAGC 
CTGCGCAACC GCGCCGAGGA GTGGGCCAGC AAGCCCAAGA TGGTCCGCGA CACGCTGCTC 
ACGCTGGCAG GCTGCACGCC CTACGAGGTT CGCTTCAAGA AGGACCACTC GCTGCTGGGC 
CGCGTTTTCG CCTTCGACGC CGTCTCCAAG CCCGGCATGG ACTACGAATT GAAGCTGTTC 
ATTGAGTACC CCACGGGCTC GGGCAACGTG TACTCCAGTG CATCTGGTGT GGCCAAGCAG 
ATGTATCAGG ACTGCATGAA GGACTTCGGC CGGGGCCTAT CCTCGGGTTT CAAGTACCTG 
GAGTACGAAA AGAAGCACGG CTCCGGGGAC TGGCGCCTGC TTGGAGACCT GCTCCCCGAA 
GCCGTGCGCT TCTTCAAGGA GGGCGTGCCC GGCGCCGACA TGCTGCCCCA GCCCTACCTG 
GACGCCAGCT GTCCCATGCT GCCCACTGCT CTGGTGAGTC TGAGCCGCGC CCCCAGCGCA 
CCCCCGGGGA CCGGGGCCTT GCCGCCCGCC GCGCCGTCGG GCCGGGGCGC AGCCGCCAGC 
CTGCGCAAGA GAAAGGCCTC TCCGGAGCCC CCGGACTCAG CCGAGGGCGC GCTGAAGCTG 
GGCGAGGAAC AGCAGAGGCA GCAGTGGATG GCGAACCAGA GCGAGGCGCT GAAGCTCACC 
ATGTCCGCCG GGGGCTTCGC GGCGCCGGGG CACGCGGCGG GGGGTCCGCC TCCGCCGCCC 
CCACCTCTGG GACCCCATTC CAACCGGACC ACCCCACCTG AGTCAGCCCC CCAGAACGGT 
CCGTCCCCTA TGGCCGCTCT CATGTCGGTG GCAGATACTC TGGGCACAGC GCACTCGCCC 
AAGGATGGCA GTTCCGTGCA CTCTACCACT GCGTCGGCGC GGCGAAACAG CAGCAGCCCA 
GTCTCGCCGG CCTCCGTGCC GGGGCAGCGC CGCTTGGCAT CACGTAACGG GGACCTGAAT 
TTACAGGTGG CGCCCCCGCC GCCTAGCGCC CACCCGGGCA TGGACCAAGT GCACCCCCAA 
AACATTCCGG ATTCCCCCAT GGCCAACAGC GGACCCCTCT GCTGCACCAT TTGCCACGAA 
CGTTTGGAGG ATACGCATTT CGTTCAGTGC CCTTCCGTCC CCAGCCACAA ATTTTGCTTC 
CCTTGCTCTA GAGAGAGTAT CAAGGCCCAG GGGGCCACCG GCGAGGTGTA TTGCCCCAGC 
GGAGAGAAAT GCCCCCTAGT CGGGTCGAAT GTACCTTGGG CCTTCATGCA GGGCGAAATC 
GCGACTATCT TAGCTGGGGA TGTTAAAGTG AAAAAGGAGA GAGACCCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IRF2BPL ( NM_024496.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_078772.1 Homo sapiens interferon regulatory factor 2 binding protein like (IRF2BPL), mRNA.

Price & Availability↑

CloneID	OHu11949
Clone ID Related Accession (Same CDS sequence)	NM_024496.3 , NM_024496.4
Accession Version	NM_024496.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2391bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577548800000
Organism	Homo sapiens(human)
Product	probable E3 ubiquitin-protein ligase IRF2BPL
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007686.5 and BC108292.1. On Nov 23, 2018 this sequence version replaced NM_024496.3. ##Evidence-Data-START## Transcript is intronless :: BC108292.1, SRR7346977.1572721.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000238647.5/ ENSP00000238647.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGCGG CGCAGGTGTC CTCGTCCCGG AGACAATCTT GCTACCTGTG CGACCTGCCC 
CGCATGCCCT GGGCCATGAT CTGGGACTTC TCGGAACCCG TATGCCGCGG TTGCGTCAAC 
TACGAGGGCG CTGATCGCAT CGAATTCGTG ATCGAGACAG CGCGCCAGCT GAAGCGGGCG 
CACGGCTGCT TCCAGGACGG CCGCTCCCCC GGGCCGCCGC CGCCCGTCGG GGTCAAGACA 
GTGGCCCTGT CGGCTAAGGA AGCGGCGGCG GCGGCGGCAG CAGCGGCGGC CGCCGCCGCC 
GCCGCGCAAC AGCAACAGCA ACAGCAGCAG CAGCAGCAGC AACAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAACAACA GCTCAACCAC GTTGATGGTT CCAGCAAGCC TGCGGTGCTG 
GCGGCCCCGT CTGGCCTGGA GCGCTACGGC CTAAGCGCTG CCGCCGCCGC CGCCGCCGCC 
GCCGCCGCTG CGGTGGAACA GCGCAGCCGC TTCGAGTACC CGCCACCGCC GGTGAGCCTG 
GGAAGCAGCA GCCACACCGC GCGACTGCCC AACGGCCTGG GGGGCCCAAA CGGCTTCCCC 
AAACCAACAC CAGAGGAGGG ACCCCCAGAG CTGAACCGTC AGAGCCCCAA TTCTTCTTCA 
GCGGCGGCGT CGGTGGCGTC TCGGCGTGGA ACGCACGGTG GGCTGGTTAC GGGGCTGCCC 
AACCCGGGGG GTGGCGGAGG CCCCCAGCTC ACCGTGCCCC CCAACCTGCT ACCGCAGACG 
CTGCTTAACG GCCCGGCCAG CGCTGCGGTA CTCCCCCCAC CCCCTCCCCA CGCCCTGGGC 
AGCCGTGGGC CCCCGACGCC TGCTCCCCCA GGGGCTCCTG GGGGCCCCGC TTGTCTCGGG 
GGTACCCCGG GTGTATCGGC CACGTCGTCC TCCGCGTCGT CTTCGACCTC TTCGTCGGTG 
GCAGAGGTGG GCGTGGGTGC TGGTGGTAAG AGGCCCGGCT CGGTGTCGAG CACAGACCAG 
GAGCGCGAGT TGAAGGAGAA GCAGCGCAAC GCCGAGGCCC TGGCCGAGCT GAGCGAGAGC 
CTGCGCAACC GCGCCGAGGA GTGGGCCAGC AAGCCCAAGA TGGTCCGCGA CACGCTGCTC 
ACGCTGGCAG GCTGCACGCC CTACGAGGTT CGCTTCAAGA AGGACCACTC GCTGCTGGGC 
CGCGTTTTCG CCTTCGACGC CGTCTCCAAG CCCGGCATGG ACTACGAATT GAAGCTGTTC 
ATTGAGTACC CCACGGGCTC GGGCAACGTG TACTCCAGTG CATCTGGTGT GGCCAAGCAG 
ATGTATCAGG ACTGCATGAA GGACTTCGGC CGGGGCCTAT CCTCGGGTTT CAAGTACCTG 
GAGTACGAAA AGAAGCACGG CTCCGGGGAC TGGCGCCTGC TTGGAGACCT GCTCCCCGAA 
GCCGTGCGCT TCTTCAAGGA GGGCGTGCCC GGCGCCGACA TGCTGCCCCA GCCCTACCTG 
GACGCCAGCT GTCCCATGCT GCCCACTGCT CTGGTGAGTC TGAGCCGCGC CCCCAGCGCA 
CCCCCGGGGA CCGGGGCCTT GCCGCCCGCC GCGCCGTCGG GCCGGGGCGC AGCCGCCAGC 
CTGCGCAAGA GAAAGGCCTC TCCGGAGCCC CCGGACTCAG CCGAGGGCGC GCTGAAGCTG 
GGCGAGGAAC AGCAGAGGCA GCAGTGGATG GCGAACCAGA GCGAGGCGCT GAAGCTCACC 
ATGTCCGCCG GGGGCTTCGC GGCGCCGGGG CACGCGGCGG GGGGTCCGCC TCCGCCGCCC 
CCACCTCTGG GACCCCATTC CAACCGGACC ACCCCACCTG AGTCAGCCCC CCAGAACGGT 
CCGTCCCCTA TGGCCGCTCT CATGTCGGTG GCAGATACTC TGGGCACAGC GCACTCGCCC 
AAGGATGGCA GTTCCGTGCA CTCTACCACT GCGTCGGCGC GGCGAAACAG CAGCAGCCCA 
GTCTCGCCGG CCTCCGTGCC GGGGCAGCGC CGCTTGGCAT CACGTAACGG GGACCTGAAT 
TTACAGGTGG CGCCCCCGCC GCCTAGCGCC CACCCGGGCA TGGACCAAGT GCACCCCCAA 
AACATTCCGG ATTCCCCCAT GGCCAACAGC GGACCCCTCT GCTGCACCAT TTGCCACGAA 
CGTTTGGAGG ATACGCATTT CGTTCAGTGC CCTTCCGTCC CCAGCCACAA ATTTTGCTTC 
CCTTGCTCTA GAGAGAGTAT CAAGGCCCAG GGGGCCACCG GCGAGGTGTA TTGCCCCAGC 
GGAGAGAAAT GCCCCCTAGT CGGGTCGAAT GTACCTTGGG CCTTCATGCA GGGCGAAATC 
GCGACTATCT TAGCTGGGGA TGTTAAAGTG AAAAAGGAGA GAGACCCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078772.1
CDS	917..3307
Translation	MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRAHGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQQQQQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSLGSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLPNPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACLGGTPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSESLRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAAASLRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPPPPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSPVSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDP

Target ORF information:

RefSeq Version	NM_024496.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon regulatory factor 2 binding protein like (IRF2BPL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024496.4

ORF Insert Sequence:

ATGTCGGCGG CGCAGGTGTC CTCGTCCCGG AGACAATCTT GCTACCTGTG CGACCTGCCC 
CGCATGCCCT GGGCCATGAT CTGGGACTTC TCGGAACCCG TATGCCGCGG TTGCGTCAAC 
TACGAGGGCG CTGATCGCAT CGAATTCGTG ATCGAGACAG CGCGCCAGCT GAAGCGGGCG 
CACGGCTGCT TCCAGGACGG CCGCTCCCCC GGGCCGCCGC CGCCCGTCGG GGTCAAGACA 
GTGGCCCTGT CGGCTAAGGA AGCGGCGGCG GCGGCGGCAG CAGCGGCGGC CGCCGCCGCC 
GCCGCGCAAC AGCAACAGCA ACAGCAGCAG CAGCAGCAGC AACAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAACAACA GCTCAACCAC GTTGATGGTT CCAGCAAGCC TGCGGTGCTG 
GCGGCCCCGT CTGGCCTGGA GCGCTACGGC CTAAGCGCTG CCGCCGCCGC CGCCGCCGCC 
GCCGCCGCTG CGGTGGAACA GCGCAGCCGC TTCGAGTACC CGCCACCGCC GGTGAGCCTG 
GGAAGCAGCA GCCACACCGC GCGACTGCCC AACGGCCTGG GGGGCCCAAA CGGCTTCCCC 
AAACCAACAC CAGAGGAGGG ACCCCCAGAG CTGAACCGTC AGAGCCCCAA TTCTTCTTCA 
GCGGCGGCGT CGGTGGCGTC TCGGCGTGGA ACGCACGGTG GGCTGGTTAC GGGGCTGCCC 
AACCCGGGGG GTGGCGGAGG CCCCCAGCTC ACCGTGCCCC CCAACCTGCT ACCGCAGACG 
CTGCTTAACG GCCCGGCCAG CGCTGCGGTA CTCCCCCCAC CCCCTCCCCA CGCCCTGGGC 
AGCCGTGGGC CCCCGACGCC TGCTCCCCCA GGGGCTCCTG GGGGCCCCGC TTGTCTCGGG 
GGTACCCCGG GTGTATCGGC CACGTCGTCC TCCGCGTCGT CTTCGACCTC TTCGTCGGTG 
GCAGAGGTGG GCGTGGGTGC TGGTGGTAAG AGGCCCGGCT CGGTGTCGAG CACAGACCAG 
GAGCGCGAGT TGAAGGAGAA GCAGCGCAAC GCCGAGGCCC TGGCCGAGCT GAGCGAGAGC 
CTGCGCAACC GCGCCGAGGA GTGGGCCAGC AAGCCCAAGA TGGTCCGCGA CACGCTGCTC 
ACGCTGGCAG GCTGCACGCC CTACGAGGTT CGCTTCAAGA AGGACCACTC GCTGCTGGGC 
CGCGTTTTCG CCTTCGACGC CGTCTCCAAG CCCGGCATGG ACTACGAATT GAAGCTGTTC 
ATTGAGTACC CCACGGGCTC GGGCAACGTG TACTCCAGTG CATCTGGTGT GGCCAAGCAG 
ATGTATCAGG ACTGCATGAA GGACTTCGGC CGGGGCCTAT CCTCGGGTTT CAAGTACCTG 
GAGTACGAAA AGAAGCACGG CTCCGGGGAC TGGCGCCTGC TTGGAGACCT GCTCCCCGAA 
GCCGTGCGCT TCTTCAAGGA GGGCGTGCCC GGCGCCGACA TGCTGCCCCA GCCCTACCTG 
GACGCCAGCT GTCCCATGCT GCCCACTGCT CTGGTGAGTC TGAGCCGCGC CCCCAGCGCA 
CCCCCGGGGA CCGGGGCCTT GCCGCCCGCC GCGCCGTCGG GCCGGGGCGC AGCCGCCAGC 
CTGCGCAAGA GAAAGGCCTC TCCGGAGCCC CCGGACTCAG CCGAGGGCGC GCTGAAGCTG 
GGCGAGGAAC AGCAGAGGCA GCAGTGGATG GCGAACCAGA GCGAGGCGCT GAAGCTCACC 
ATGTCCGCCG GGGGCTTCGC GGCGCCGGGG CACGCGGCGG GGGGTCCGCC TCCGCCGCCC 
CCACCTCTGG GACCCCATTC CAACCGGACC ACCCCACCTG AGTCAGCCCC CCAGAACGGT 
CCGTCCCCTA TGGCCGCTCT CATGTCGGTG GCAGATACTC TGGGCACAGC GCACTCGCCC 
AAGGATGGCA GTTCCGTGCA CTCTACCACT GCGTCGGCGC GGCGAAACAG CAGCAGCCCA 
GTCTCGCCGG CCTCCGTGCC GGGGCAGCGC CGCTTGGCAT CACGTAACGG GGACCTGAAT 
TTACAGGTGG CGCCCCCGCC GCCTAGCGCC CACCCGGGCA TGGACCAAGT GCACCCCCAA 
AACATTCCGG ATTCCCCCAT GGCCAACAGC GGACCCCTCT GCTGCACCAT TTGCCACGAA 
CGTTTGGAGG ATACGCATTT CGTTCAGTGC CCTTCCGTCC CCAGCCACAA ATTTTGCTTC 
CCTTGCTCTA GAGAGAGTAT CAAGGCCCAG GGGGCCACCG GCGAGGTGTA TTGCCCCAGC 
GGAGAGAAAT GCCCCCTAGT CGGGTCGAAT GTACCTTGGG CCTTCATGCA GGGCGAAATC 
GCGACTATCT TAGCTGGGGA TGTTAAAGTG AAAAAGGAGA GAGACCCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

De novo truncating variants in the intronless IRF2BPL are responsible for developmental epileptic encephalopathy.
Genetics in medicine : official journal of the American College of Medical Genetics21(4)1008-1014(2019 04)
Tran Mau-Them F,Guibaud L,Duplomb L,Keren B,Lindstrom K,Marey I,Mochel F,van den Boogaard MJ,Oegema R,Nava C,Masurel A,Jouan T,Jansen FE,Au M,Chen AH,Cho M,Duffourd Y,Lozier E,Konovalov F,Sharkov A,Korostelev S,Urteaga B,Dickson P,Vera M,Martínez-Agosto JA,Begemann A,Zweier M,Schmitt-Mechelke T,Rauch A,Philippe C,van Gassen K,Nelson S,Graham JM Jr,Friedman J,Faivre L,Lin HJ,Thauvin-Robinet C,Vitobello A

IRF2BPL Is Associated with Neurological Phenotypes.
American journal of human genetics103(2)245-260(2018 08)
Marcogliese PC,Shashi V,Spillmann RC,Stong N,Rosenfeld JA,Koenig MK,Martínez-Agosto JA,Herzog M,Chen AH,Dickson PI,Lin HJ,Vera MU,Salamon N,Graham JM Jr,Ortiz D,Infante E,Steyaert W,Dermaut B,Poppe B,Chung HL,Zuo Z,Lee PT,Kanca O,Xia F,Yang Y,Smith EC,Jasien J,Kansagra S,Spiridigliozzi G,El-Dairi M,Lark R,Riley K,Koeberl DD,Golden-Grant K,,,Yamamoto S,Wangler MF,Mirzaa G,Hemelsoet D,Lee B,Nelson SF,Goldstein DB,Bellen HJ,Pena LDM

Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis.
Cancer research78(7)1643-1656(2018 04)
Higashimori A,Dong Y,Zhang Y,Kang W,Nakatsu G,Ng SSM,Arakawa T,Sung JJY,Chan FKL,Yu J

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
Oncology reports28(2)429-38(2012 Aug)
Böhm D,Keller K,Pieter J,Boehm N,Wolters D,Siggelkow W,Lebrecht A,Schmidt M,Kölbl H,Pfeiffer N,Grus FH

Hypothalamic expression of Eap1 is not directly controlled by ovarian steroids.
Endocrinology150(4)1870-8(2009 Apr)
Matagne V,Mastronardi C,Shapiro RA,Dorsa DM,Ojeda SR

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IRF2BPL cDNA ORF clone, Homo sapiens(human)

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