| Gene Symbol | FITM2 |
| Entrez Gene ID | 128486 |
| Full Name | fat storage inducing transmembrane protein 2 |
| Synonyms | C20orf142,Fit2,dJ881L22.2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | FIT2 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]. |
| Disorder MIM: |
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FITM2 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following FITM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FITM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu29081 Clone ID Related Accession (Same CDS sequence) NM_001080472.4 , NM_001080472.3 Accession Version NM_001080472.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 789bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1572105600000 Organism Homo sapiens(human) Product fat storage-inducing transmembrane protein 2 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from KF456918.1 and AL117382.28. On Nov 22, 2018 this sequence version replaced NM_001080472.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.265784.1, SRR1660809.177131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000396825.4/ ENSP00000380037.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGGAGCATC TGGAGCGCTG CGAGTGGTTG TTGCGGGGGA CGCTGGTGCG GGCGGCCGTG
CGGCGCTACC TGCCCTGGGC CCTGGTGGCC TCCATGCTGG CGGGCTCCCT CCTCAAGGAG
TTGTCCCCGT TGCCCGAGAG CTACCTCAGC AACAAGCGCA ACGTCCTCAA CGTGTATTTT
GTCAAAGTGG CCTGGGCCTG GACGTTCTGT CTCCTTCTGC CTTTCATTGC CCTCACCAAC
TACCATCTGA CCGGCAAGGC TGGCTTGGTC CTGCGGCGGC TGAGCACCCT GCTTGTGGGC
ACGGCCATCT GGTACATCTG CACCTCCATC TTCTCCAACA TCGAACACTA CACGGGCAGC
TGCTACCAGT CCCCAGCCCT GGAGGGGGTC AGAAAGGAAC ACCAGAGCAA GCAGCAGTGC
CACCAGGAAG GGGGCTTTTG GCATGGCTTT GACATCTCAG GTCACTCCTT CCTGCTGACC
TTCTGCGCCC TCATGATTGT AGAAGAGATG TCTGTGCTGC ATGAGGTGAA GACGGACCGA
AGCCACTGCC TCCACACCGC CATCACCACC CTGGTTGTGG CCCTGGGCAT TCTGACTTTC
ATCTGGGTGT TGATGTTTCT GTGCACAGCT GTTTATTTCC ACAACTTGTC CCAGAAGGTG
TTTGGCACCT TGTTTGGTTT GCTGAGCTGG TACGGGACAT ACGGGTTTTG GTATCCGAAA
GCCTTTTCCC CAGGACTTCC TCCCCAGAGC TGTAGTTTGA ATTTGAAGCA AGATAGTTAC
AAGAAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001073941.1 CDS 55..843 Translation 
Target ORF information:
RefSeq Version NM_001080472.4 Organism Homo sapiens(human) Definition Homo sapiens fat storage inducing transmembrane protein 2 (FITM2), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001080472.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGGAGCATC TGGAGCGCTG CGAGTGGTTG TTGCGGGGGA CGCTGGTGCG GGCGGCCGTG
CGGCGCTACC TGCCCTGGGC CCTGGTGGCC TCCATGCTGG CGGGCTCCCT CCTCAAGGAG
TTGTCCCCGT TGCCCGAGAG CTACCTCAGC AACAAGCGCA ACGTCCTCAA CGTGTATTTT
GTCAAAGTGG CCTGGGCCTG GACGTTCTGT CTCCTTCTGC CTTTCATTGC CCTCACCAAC
TACCATCTGA CCGGCAAGGC TGGCTTGGTC CTGCGGCGGC TGAGCACCCT GCTTGTGGGC
ACGGCCATCT GGTACATCTG CACCTCCATC TTCTCCAACA TCGAACACTA CACGGGCAGC
TGCTACCAGT CCCCAGCCCT GGAGGGGGTC AGAAAGGAAC ACCAGAGCAA GCAGCAGTGC
CACCAGGAAG GGGGCTTTTG GCATGGCTTT GACATCTCAG GTCACTCCTT CCTGCTGACC
TTCTGCGCCC TCATGATTGT AGAAGAGATG TCTGTGCTGC ATGAGGTGAA GACGGACCGA
AGCCACTGCC TCCACACCGC CATCACCACC CTGGTTGTGG CCCTGGGCAT TCTGACTTTC
ATCTGGGTGT TGATGTTTCT GTGCACAGCT GTTTATTTCC ACAACTTGTC CCAGAAGGTG
TTTGGCACCT TGTTTGGTTT GCTGAGCTGG TACGGGACAT ACGGGTTTTG GTATCCGAAA
GCCTTTTCCC CAGGACTTCC TCCCCAGAGC TGTAGTTTGA ATTTGAAGCA AGATAGTTAC
AAGAAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu29081 Clone ID Related Accession (Same CDS sequence) NM_001080472.4 , NM_001080472.3 Accession Version NM_001080472.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 789bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1512835200000 Organism Homo sapiens(human) Product fat storage-inducing transmembrane protein 2 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from KF456918.1 and AL117382.28. On Aug 14, 2016 this sequence version replaced NM_001080472.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.265784.1, SRR1660809.177131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGGAGCATC TGGAGCGCTG CGAGTGGTTG TTGCGGGGGA CGCTGGTGCG GGCGGCCGTG
CGGCGCTACC TGCCCTGGGC CCTGGTGGCC TCCATGCTGG CGGGCTCCCT CCTCAAGGAG
TTGTCCCCGT TGCCCGAGAG CTACCTCAGC AACAAGCGCA ACGTCCTCAA CGTGTATTTT
GTCAAAGTGG CCTGGGCCTG GACGTTCTGT CTCCTTCTGC CTTTCATTGC CCTCACCAAC
TACCATCTGA CCGGCAAGGC TGGCTTGGTC CTGCGGCGGC TGAGCACCCT GCTTGTGGGC
ACGGCCATCT GGTACATCTG CACCTCCATC TTCTCCAACA TCGAACACTA CACGGGCAGC
TGCTACCAGT CCCCAGCCCT GGAGGGGGTC AGAAAGGAAC ACCAGAGCAA GCAGCAGTGC
CACCAGGAAG GGGGCTTTTG GCATGGCTTT GACATCTCAG GTCACTCCTT CCTGCTGACC
TTCTGCGCCC TCATGATTGT AGAAGAGATG TCTGTGCTGC ATGAGGTGAA GACGGACCGA
AGCCACTGCC TCCACACCGC CATCACCACC CTGGTTGTGG CCCTGGGCAT TCTGACTTTC
ATCTGGGTGT TGATGTTTCT GTGCACAGCT GTTTATTTCC ACAACTTGTC CCAGAAGGTG
TTTGGCACCT TGTTTGGTTT GCTGAGCTGG TACGGGACAT ACGGGTTTTG GTATCCGAAA
GCCTTTTCCC CAGGACTTCC TCCCCAGAGC TGTAGTTTGA ATTTGAAGCA AGATAGTTAC
AAGAAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001073941.1 CDS 105..893 Translation
Target ORF information:
RefSeq Version NM_001080472.3 Organism Homo sapiens(human) Definition Homo sapiens fat storage inducing transmembrane protein 2 (FITM2), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001080472.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGGAGCATC TGGAGCGCTG CGAGTGGTTG TTGCGGGGGA CGCTGGTGCG GGCGGCCGTG
CGGCGCTACC TGCCCTGGGC CCTGGTGGCC TCCATGCTGG CGGGCTCCCT CCTCAAGGAG
TTGTCCCCGT TGCCCGAGAG CTACCTCAGC AACAAGCGCA ACGTCCTCAA CGTGTATTTT
GTCAAAGTGG CCTGGGCCTG GACGTTCTGT CTCCTTCTGC CTTTCATTGC CCTCACCAAC
TACCATCTGA CCGGCAAGGC TGGCTTGGTC CTGCGGCGGC TGAGCACCCT GCTTGTGGGC
ACGGCCATCT GGTACATCTG CACCTCCATC TTCTCCAACA TCGAACACTA CACGGGCAGC
TGCTACCAGT CCCCAGCCCT GGAGGGGGTC AGAAAGGAAC ACCAGAGCAA GCAGCAGTGC
CACCAGGAAG GGGGCTTTTG GCATGGCTTT GACATCTCAG GTCACTCCTT CCTGCTGACC
TTCTGCGCCC TCATGATTGT AGAAGAGATG TCTGTGCTGC ATGAGGTGAA GACGGACCGA
AGCCACTGCC TCCACACCGC CATCACCACC CTGGTTGTGG CCCTGGGCAT TCTGACTTTC
ATCTGGGTGT TGATGTTTCT GTGCACAGCT GTTTATTTCC ACAACTTGTC CCAGAAGGTG
TTTGGCACCT TGTTTGGTTT GCTGAGCTGG TACGGGACAT ACGGGTTTTG GTATCCGAAA
GCCTTTTCCC CAGGACTTCC TCCCCAGAGC TGTAGTTTGA ATTTGAAGCA AGATAGTTAC
AAGAAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology33(1)430-440(2019 01)
Agrawal M,Yeo CR,Shabbir A,Chhay V,Silver DL,Magkos F,Vidal-Puig A,Toh SA
A homozygous FITM2 mutation causes a deafness-dystonia syndrome with motor regression and signs of ichthyosis and sensory neuropathy.
Disease models & mechanisms10(2)105-118(2017 02)
Zazo Seco C,Castells-Nobau A,Joo SH,Schraders M,Foo JN,van der Voet M,Velan SS,Nijhof B,Oostrik J,de Vrieze E,Katana R,Mansoor A,Huynen M,Szklarczyk R,Oti M,Tranebjærg L,van Wijk E,Scheffer-de Gooyert JM,Siddique S,Baets J,de Jonghe P,Kazmi SA,Sadananthan SA,van de Warrenburg BP,Khor CC,Göpfert MC,Qamar R,Schenck A,Kremer H,Siddiqi S
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.
BMC biology954(2011 Aug)
Bai SW,Herrera-Abreu MT,Rohn JL,Racine V,Tajadura V,Suryavanshi N,Bechtel S,Wiemann S,Baum B,Ridley AJ
Evolutionarily conserved gene family important for fat storage.
Proceedings of the National Academy of Sciences of the United States of America105(1)94-9(2008 Jan)
Kadereit B,Kumar P,Wang WJ,Miranda D,Snapp EL,Severina N,Torregroza I,Evans T,Silver DL
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