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quadruplex DNA

A form of DNA in which four oligo(G) sequences, either of the same or of different strands, LINE up either in a parallel, an anti-parallel or in a fold-back (mixed parallel and antiparallel) pattern. The interior of quadruple the helix has four guanine bases in Hoogstein base pairings; each plane of four guanines is separated from the adjacent plane by a Na+ or K+ ion. Although these structures have not been identified cells, they are strongly suspected to cap the ends of chromosomal DNA. see telomerePalecek, E. (1991) Crit. Rev. Biochem. Mol. Biol. 26, 151-226; Yagil, G. (1991) Crit. Rev. Biochem. Mol. Biol. 26, 475-559; Borman, S. (1998) Chem. Eng. News 76 (40) 42-46

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