State of art in antibody engineering for better therapeutic antibodies

With the advent of advanced technology, we can now reach the targets that previously known as "undruggable" due to the availability of high diversity antibodies. However, finding the right candidates among the high diversity antibodies can be time-consuming, and researchers would have experienced challenges such as missing out good binders, poor antibody library coverage, throughout the discovery and development workflow.

Several attempts have been made to address these challenges. Recently, the development of synthetic biology provides the breakthrough that allow the researchers to precisely define and control the synthesis of high-diversity domain libraries. The optimization process usually requires several rounds of the mutant library construction and screening in order to isolate the top ideal candidate.

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