Bispecific Single-Domain Antibody fused to Monoclonal Antibody (SMAB): The Natural Form

Within the past 3 years alone, the FDA has approved 20 novel antibody therapeutics for oncological treatment, with over 300 therapeutic antibodies currently in oncology based clinical trials. However, despite this exponential growth, most therapeutic antibodies rely on a monomeric immunotherapy based mechanism. Therefore, there is an urgent demand for new therapeutic strategies, such as combinatorial therapy, and novel modalities, such as bispecific antibodies.

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