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Webinars » Molecular Classification-based identification of diagnostic and treatment targets in glioma
Adult glioma is a classic example that intensive research efforts in the areas of genomic sequencing, targeting genomic and epigenetic abnormalities have not identified subtype-specific pathways of pathogenesis and targetable vulnerabilities. A major source of this dilemma is that current classification standard, though prognostically relevant under the existing treatment options, fails to assign gliomas into biologically distinct entities. Transcriptome-based classification may integrate the effects between cell of origin and driving genomic alterations, and assign gliomas into distinct biology entities exhibiting biology-driven clinical manifestations. Thus, transcriptome-based subtyping may enable the identification of subtype-specific vulnerabilities. We hypothesize that key signaling pathways converged between neural development and gliomagenesis, and gene networks spanning these pathways might enable molecular classification of gliomas.