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Immunofluorescent localization of thyroglobulin--autoantibody producing cells in various organs of obese strain (OS) chickens

Z Immunitatsforsch Immunobiol. 2015; 
Kofler R, Wick G.
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Abstract

The Obese strain (OS) of White Leghorn chickens develops a spontaneous autoimmune thyroiditis with circulating thyroglobulin-autoantibodies (Tg-AAb) similar to human Hashimoto thyroiditis. The paper describes attempts to localize the site of Tg-AAb production in various organs of these animals using the immunofluorescence method. Tg-AAb producing plasma cells and germinal centers could be detected in the infiltrated thyroid glands but not in spleen, bone marrow, coecal tonsils, thymus, bursa of Fabricius and Harderian glands.

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