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Yam storage protein dioscorins modulate cytokine gene expression in BALB/c and C57BL/6 lymphocytes.

Food Agric Immunol.. 2015;  26(6)
Yu-Jhen Hsu, Jung-Hsin Hsu, Kuo-Chih Lin. Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien County 974, Taiwan.
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Abstract

This study aimed to evaluate the effects of dioscorins isolated from 2 yam species, Dioscorea alata (Da-dioscorins) and Dioscorea japonica (Dj-dioscorins), on mouse immune activities. Results from cytokine array indicated that Dj-dioscorins increased the production of tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-3, IL-6, IL-10, IL-12p40, IL-13, monocyte chemoattractant protein (MCP)-1, regulated on activation, normal T cell expressed and secreted (RANTES), and granulocyte colony-stimulating factor (GCSF) in the spleen cells of BALB/c mice. In RAW264.7 macrophage, Da-dioscorins upregulated the expression of TNF-α, IL-1β, IL-6, IL-10, RANTES, MCP-1, and GCSF genes to a greater extent tha... More

Keywords

dioscorin; cytokine array; traditional herbal medicine; polymyxin B