Isl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Isl2
Entrez Gene ID	57233
Full Name	ISL LIM homeobox 2
General protein information	Preferred Names ISL LIM homeobox 2 Names insulin gene enhancer protein ISL-2 insulin related protein 2 (islet 2) islet-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	LIM homeobox transcription factor; involved in topographic organization of motor neurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243089.1	XP_006243151.1	insulin gene enhancer protein ISL-2 isoform X1
NM_020471.1	NP_065204.1	insulin gene enhancer protein ISL-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ISL2	NP_665804.1
Mus musculus (house mouse)	Isl2	NP_081673.2
Rattus norvegicus (Norway rat)	Isl2	NP_065204.1
Danio rerio (zebrafish)	isl2a	NP_571045.1
Pan troglodytes (chimpanzee)	ISL2	XP_003314842.1
Macaca mulatta (Rhesus monkey)	ISL2	XP_001105068.1
Bos taurus (cattle)	ISL2	NP_001178166.1

Gene Ontology
Bibliography

Related articles in PubMed

Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development.
Serinagaoglu Y, Paré J, Giovannini M, Cao X
Developmental biology398(1)97-109(2015 Feb)

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity.
Song MR, Sun Y, Bryson A, Gill GN, Evans SM, Pfaff SL
Development (Cambridge, England)136(17)2923-32(2009 Sep)

Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding.
Pak W, Hindges R, Lim YS, Pfaff SL, O'Leary DD
Cell119(4)567-78(2004 Nov)

A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity.
Thaler JP, Koo SJ, Kania A, Lettieri K, Andrews S, Cox C, Jessell TM, Pfaff SL
Neuron41(3)337-50(2004 Feb)

The solution structure of the homeodomain of the rat insulin-gene enhancer protein isl-1. Comparison with other homeodomains.
Ippel H, Larsson G, Behravan G, Zdunek J, Lundqvist M, Schleucher J, Lycksell PO, Wijmenga S
Journal of molecular biology288(4)689-703(1999 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Isl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Isl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04792	NM_020471.1 Latest version!	Rattus norvegicus ISL LIM homeobox 2 (Isl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa31177	XM_006243089.1 Latest version!	Rattus norvegicus ISL LIM homeobox 2 (Isl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Isl2 ( NM_020471.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_065204.1 Rattus norvegicus ISL LIM homeobox 2 (Isl2), mRNA.

Price & Availability↑

CloneID	ORa04792
Clone ID Related Accession (Same CDS sequence)	NM_020471.1
Accession Version	NM_020471.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	insulin gene enhancer protein ISL-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L35571.1. ##Evidence-Data-START## Transcript exon combination :: L35571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGGGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTT 
CGGGTGTCGC CCGACCTCGA GTGGCACGCC GCCTGCCTCA AGTGCGCTGA GTGCAGCCAG 
TATCTGGATG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AAACGTACTG CAAGCGGGAC 
TACGTCAGGC TGTTCGGCAT CAAGTGTGCC CAGTGTCAGG TGGGCTTCAG CAGCAGTGAC 
CTGGTGATGC GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTCCCTGG AGACGAGTTC TCGCTGAGGG AGCACGAGCT GCTCTGCCGA 
GCCGACCACG GCCTCCTGCT GGAGCGCGCT GCGGCCGGCA GCCCGCGCAG CCCTGGCCCG 
CTCCCCGGCA CCCCACCAGG CCTGCATCTG CCAGACGCCG GGTCCGGACA ACAGGTCTCA 
CTGCGCACGC ACGTGCACAA GCAGGCGGAG AAGACAACCC GGGTGCGGAC TGTGCTCAAC 
GAGAAGCAAC TGCACACCCT GCGGACATGC TACGCCGCCA ACCCGCGGCC CGACGCGCTC 
ATGAAGGAGC AGCTGGTAGA GATGACCGGC TTGAGCCCGC GGGTCATCCG CGTGTGGTTT 
CAGAACAAGC GTTGCAAGGA CAAGAAGAAG TCCATTCTCA TGAAGCAGCT ACAGCAGCAG 
CAACACAGCG ACAAGGCGAG TCTCCAGGGA CTAACTGGGA CGCTCCTGGT GGCGGGCAGC 
CCATCCGCCC ATGAGAACGC CGTGCAGGGC AGCGCAGTCG AGGTGCAGAC GTACCAGCCG 
CCCTGGAAAG CTCTCAGCGA GTTCGCACTC CAGAGCGACC TGGATCAACC CGCCTTTCAA 
CAGCTGGTCT CCTTCTCCGA GTCAGGCTCC CTAGGCAACT CCTCTGGTAG CGACGTGACC 
TCTCTGTCTT CGCAGCTCCC GGACACCCCC AACAGTATGG TACCTAGTCC GGTGGAGACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065204.1
CDS	77..1159
Translation	MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAQCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGTPPGLHLPDAGSGQQVSLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTLLVAGSPSAHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET

Target ORF information:

RefSeq Version	NM_020471.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ISL LIM homeobox 2 (Isl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020471.1

ORF Insert Sequence:

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGGGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTT 
CGGGTGTCGC CCGACCTCGA GTGGCACGCC GCCTGCCTCA AGTGCGCTGA GTGCAGCCAG 
TATCTGGATG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AAACGTACTG CAAGCGGGAC 
TACGTCAGGC TGTTCGGCAT CAAGTGTGCC CAGTGTCAGG TGGGCTTCAG CAGCAGTGAC 
CTGGTGATGC GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTCCCTGG AGACGAGTTC TCGCTGAGGG AGCACGAGCT GCTCTGCCGA 
GCCGACCACG GCCTCCTGCT GGAGCGCGCT GCGGCCGGCA GCCCGCGCAG CCCTGGCCCG 
CTCCCCGGCA CCCCACCAGG CCTGCATCTG CCAGACGCCG GGTCCGGACA ACAGGTCTCA 
CTGCGCACGC ACGTGCACAA GCAGGCGGAG AAGACAACCC GGGTGCGGAC TGTGCTCAAC 
GAGAAGCAAC TGCACACCCT GCGGACATGC TACGCCGCCA ACCCGCGGCC CGACGCGCTC 
ATGAAGGAGC AGCTGGTAGA GATGACCGGC TTGAGCCCGC GGGTCATCCG CGTGTGGTTT 
CAGAACAAGC GTTGCAAGGA CAAGAAGAAG TCCATTCTCA TGAAGCAGCT ACAGCAGCAG 
CAACACAGCG ACAAGGCGAG TCTCCAGGGA CTAACTGGGA CGCTCCTGGT GGCGGGCAGC 
CCATCCGCCC ATGAGAACGC CGTGCAGGGC AGCGCAGTCG AGGTGCAGAC GTACCAGCCG 
CCCTGGAAAG CTCTCAGCGA GTTCGCACTC CAGAGCGACC TGGATCAACC CGCCTTTCAA 
CAGCTGGTCT CCTTCTCCGA GTCAGGCTCC CTAGGCAACT CCTCTGGTAG CGACGTGACC 
TCTCTGTCTT CGCAGCTCCC GGACACCCCC AACAGTATGG TACCTAGTCC GGTGGAGACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Isl2 ( XM_006243089.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243151.1 Rattus norvegicus ISL LIM homeobox 2 (Isl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31177
Clone ID Related Accession (Same CDS sequence)	XM_006243089.1
Accession Version	XM_006243089.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1011bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	insulin gene enhancer protein ISL-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGGGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTT 
CGGGTGTCGC CCGACCTCGA GTGGCACGCC GCCTGCCTCA AGTGCGCTGA GTGCAGCCAG 
TATCTGGATG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AAACGTACTG CAAGCGGGAC 
TACGTCAGGC TGTTCGGCAT CAAGTGTGCC CAGTGTCAGG TGGGCTTCAG CAGCAGTGAC 
CTGGTGATGC GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTCCCTGG AGACGAGTTC TCGCTGAGGG AGCACGAGCT GCTCTGCCGA 
GCCGACCACG GCCTCCTGCT GGAGCGCGCT GCGGCCGGCA GCCCGCGCAG CCCTGGCCCG 
CTCCCCGGCG CCCGCGGCCT GCATCTGCCA GACGCCGGGT CCGGACGACA GTCCTCACTG 
CGCACGCACG TGCACAAGCA GGCGGAGAAG ACAACCCGGG TGCGGACTGT GCTCAACGAG 
AAGCAACTGC ACACCCTGCG GACATGCTAC GCCGCCAACC CGCGGCCCGA CGCGCTCATG 
AAGGAGCAGC TGGTAGAGAT GACCGGCTTG AGCCCGCGGG TCATCCGCGT GTGGTTTCAG 
AACAAGCGTT GCAAGGACAA GAAGAAGTCC ATTCTCATGA AGCAGCTACA GCAGCAGCAA 
CACAGCGACA AGGCGAGTCT CCAGGGACTA ACTGGGACGC CTCTGGTGGC GGGCAGCCCC 
ATCCGCCATG AGAACGCCGT GCAGGGCAGC GCAGTCGAGG TGCAGACGTA CCAGCCGCCC 
TGGAAAGCTC TCAGCGAGTT CGCACTCCAG AGCGACCTGG ATCAACCCGC CTTTCAACAG 
CTGCTCCCGG ACACCCCCAA CAGTATGGTA CCTAGTCCGG TGGAGACGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243151.1
CDS	236..1246
Translation	MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAQCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQSSLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLLPDTPNSMVPSPVET

Target ORF information:

RefSeq Version	XM_006243089.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ISL LIM homeobox 2 (Isl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243089.1

ORF Insert Sequence:

ATGGTGGATA TTATTTTTCA TTATCCTTTT CTGGGTGCTA TGGGGGATCA TTCCAAGAAG 
AAGCCCGGGA CGGCCATGTG CGTGGGCTGC GGGAGTCAGA TCCACGACCA GTTTATCCTT 
CGGGTGTCGC CCGACCTCGA GTGGCACGCC GCCTGCCTCA AGTGCGCTGA GTGCAGCCAG 
TATCTGGATG AGACGTGCAC GTGCTTCGTG AGAGACGGGA AAACGTACTG CAAGCGGGAC 
TACGTCAGGC TGTTCGGCAT CAAGTGTGCC CAGTGTCAGG TGGGCTTCAG CAGCAGTGAC 
CTGGTGATGC GGGCGCGGGA CAGCGTGTAC CACATCGAGT GCTTCCGCTG CTCCGTGTGC 
AGCCGCCAGC TGCTCCCTGG AGACGAGTTC TCGCTGAGGG AGCACGAGCT GCTCTGCCGA 
GCCGACCACG GCCTCCTGCT GGAGCGCGCT GCGGCCGGCA GCCCGCGCAG CCCTGGCCCG 
CTCCCCGGCG CCCGCGGCCT GCATCTGCCA GACGCCGGGT CCGGACGACA GTCCTCACTG 
CGCACGCACG TGCACAAGCA GGCGGAGAAG ACAACCCGGG TGCGGACTGT GCTCAACGAG 
AAGCAACTGC ACACCCTGCG GACATGCTAC GCCGCCAACC CGCGGCCCGA CGCGCTCATG 
AAGGAGCAGC TGGTAGAGAT GACCGGCTTG AGCCCGCGGG TCATCCGCGT GTGGTTTCAG 
AACAAGCGTT GCAAGGACAA GAAGAAGTCC ATTCTCATGA AGCAGCTACA GCAGCAGCAA 
CACAGCGACA AGGCGAGTCT CCAGGGACTA ACTGGGACGC CTCTGGTGGC GGGCAGCCCC 
ATCCGCCATG AGAACGCCGT GCAGGGCAGC GCAGTCGAGG TGCAGACGTA CCAGCCGCCC 
TGGAAAGCTC TCAGCGAGTT CGCACTCCAG AGCGACCTGG ATCAACCCGC CTTTCAACAG 
CTGCTCCCGG ACACCCCCAA CAGTATGGTA CCTAGTCCGG TGGAGACGTG A