Lats2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lats2
Entrez Gene ID	305922
Full Name	large tumor suppressor kinase 2
General protein information	Preferred Names large tumor suppressor kinase 2 Names serine/threonine-protein kinase LATS2 large tumor suppressor 2 large tumor suppressor, homolog 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p12

mRNA and Protein(s)

mRNA	Protein	Name
XM_008770748.2	XP_008768970.1	serine/threonine-protein kinase LATS2 isoform X1
NM_001107267.1	NP_001100737.1	serine/threonine-protein kinase LATS2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Lats2	NP_056586.2
Rattus norvegicus (Norway rat)	Lats2	NP_001100737.1
Danio rerio (zebrafish)	lats2	NP_001121728.1
Pan troglodytes (chimpanzee)	LATS2	XP_001149147.1
Gallus gallus (chicken)	LATS2	XP_417143.3
Xenopus tropicalis (tropical clawed frog)	lats2	NP_001096174.1
Homo sapiens (human)	LATS2	NP_055387.2
Canis lupus familiaris (dog)	LATS2	XP_534537.3

Gene Ontology
Bibliography

Related articles in PubMed

Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation.
Lorthongpanich C, Messerschmidt DM, Chan SW, Hong W, Knowles BB, Solter D
Genes & development27(13)1441-6(2013 Jul)

MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2.
Liu X, Cheng Y, Chen X, Yang J, Xu L, Zhang C
The Journal of biological chemistry286(49)42371-80(2011 Dec)

Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.
Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF
Science (New York, N.Y.)332(6028)458-61(2011 Apr)

The Hippo pathway regulates Wnt/beta-catenin signaling.
Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L
Developmental cell18(4)579-91(2010 Apr)

The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.
Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson RO, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki EM, Nojima H, Rossant J, Nakao K, Niwa H, Sasaki H
Developmental cell16(3)398-410(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Lats2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lats2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13716	NM_001107267.1 Latest version!	Rattus norvegicus large tumor suppressor kinase 2 (Lats2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa13716	XM_008770748.2 Latest version!	Rattus norvegicus large tumor suppressor kinase 2 (Lats2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lats2 ( NM_001107267.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100737.1 Rattus norvegicus large tumor suppressor kinase 2 (Lats2), mRNA.

Price & Availability↑

CloneID	ORa13716
Clone ID Related Accession (Same CDS sequence)	XM_008770748.2 , NM_001107267.1
Accession Version	NM_001107267.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3129bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527350400000
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase LATS2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474049.1. On or before Oct 4, 2007 this sequence version replaced XM_001063422.1, XM_224169.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCCAA AGACTTTTCC TGCTACAACT TACTCTGGAA ATAGCCGGCA GCGACTGCAA 
GAGATTCGAG AAGGACTGAA GCAGCCGGCC AAGTCTTCCA CCCAGGGGCT GCTGGTGGGA 
CCAAACAGTG ACACTTCTTC CCTGGATGCC AAAGTCCTGG GGAACAAAGA TGCCTCCAGG 
CAGCAGCAGA TGAGAGCCAC CCCGAAGTTT GGACCTTATC AAAAAGCGCT CAGGGAAATC 
CGATATTCCC TCCTGCCTTT TGCCAATGAG TCAGGCACGT CGGCAGCTGC AGAGGTGAAC 
CGGCAGATGC TGCAGGAGTT GGTGAATGCA GGATGTGACC AGGAGATGGC TGGCAGAGCG 
CTCAAGCAGA CAGGCAGTAG GAGTATTGAA GCCGCCTTGG AGTACATCAG TAAGATGGGC 
TACTTGGACC CCAGGAATGA GCAAATTGTG CGAGTCATCA AGCAGACCTC CCCAGGAAAG 
GGCCTGGTGC CCACTGCAGT GACTCGACGA CCCAGCTTTG AGGGCACAGG GGAAGCATTC 
CCATCCCACC ACCAGTTGGG CGGTGCAAAC TATGAGGGCC CCGCTGCCCT GGAGGAGATG 
CCACGGCAAT ATTTAGACTT CCTCTTCCCC GGGGCCAGCG TCCACGGCGC CCCGGCTCAC 
CAGCATCCCC CCAAAGGCTA CAGCACTGCA GTGGATGCGG GCACACACTT CCCAGGCGCA 
CACTATGGTC GTGCTCATCT ACTGTCAGAG CAGCCTGGGT ATGGGGTTCA GCGCAGCCCC 
TCCTTCCAGA GCAAGACGCC ACCAGACACC TATTCCAGCC TGGCCAAGGC CCAGGGTGGC 
CCTCCTGCCA GCCTCACCTT CCCTGCCCAT GCTGGTCTGT ACACCACCTC GCACCACAAG 
CCAGCGGCTG CAGTACCTGG GGCCCACCCC TTACATGTGT TGGGCACCCG GGGCCCCACG 
TTCACTGGGG ACAGCTCTAC GCAGGCCGTT CTGGCACCGT CCAGGAACAG CCTCAATAAT 
GACTTGTACG AGCTGGGCTC TCCCGTGCCC TGGCCCGCAG CTCCACTGGC ACGCCGTGAC 
TCGCTGCAGA AGCAGAGTCT AGAGGCCTCC CGGCCGCATG TGGCCTTCCG GGCTGGGCCC 
AGCAGGACCA ACTCCTTCAG CAGCCCACAA CCTGAGCCCT CACTGCCCGC CCCCAACACA 
GTCACTGCTG TGACGGCTGC ACACATCCTT CACCCTGTGA AGAGCGTGCG CGTGCTGCGG 
CCCGAGCCTC AGACAGCCGT GGGGCCCTCG CACCCCGCCT GGGTGCCTGC CCCCACAGCA 
CCTGCAGCCG CCGAGGGCCT GGAGAGCAAG GAGGGCAGTG CAGGCCCACC CCCGCTGGAT 
ATGGACTTCG GGGGCTCCGA GCGCAGGTGC CCACCGCCTC CTTACCCAAA GCACTTGCTG 
CTGCCCAGTA AGTCTGAGCA GTACAGCGCT GGTCTGGACC GCCTGTGCAC CGGTGTGGAG 
CAGAGTCTGC GCGGGGGCAC CGAGCAAGAC AGGAATGACA AGGGCCACAA GGGTGCTAAG 
GGGGACAAAG CTGGCAGGGA CAAAAAGCAG ATCCAGACCT CCCCAGTGCC TGTCCGCAAG 
AATAGCAGGG ATGAAGAGAA GAGAGAGTCT CGAATCAAGA GTTACTCCCC ATATGCCTTC 
AAATTCTTCA TGGAACAACA TGTGGAGAAT GTCATCAAAA CCTACCAGCA GAAGGTCAGC 
CGGAGGCTAC AGCTGGAGCA GGAAATGGCC AAAGCTGGAC TGTGCGAGAC TGAGCAGGAG 
CAGATGAGGA AGATCCTCTA CCAGAAGGAG TCGAACTACA ACAGACTCAA GAGGGCCAAG 
ATGGACAAGT CCATGTTTGT GAAAATCAAA ACTCTGGGCA TTGGTGCCTT TGGAGAAGTG 
TGCCTTGCCT GTAAGGTGGA TACTCACGCT CTGTATGCCA TGAAGACGCT GAGGAAAAAA 
GATGTCCTGA ACCGGAACCA AGTGGCCCAT GTCAAGGCTG AGAGGGACAT CCTGGCTGAA 
GCAGACAATG AGTGGGTGGT CAAACTCTAC TATTCCTTCC AGGACAAGGA CAGCCTGTAC 
TTTGTGATGG ACTACATACC TGGTGGGGAC ATGATGAGCC TGCTGATCCG GATGGAGGTC 
TTCCCTGAAC ACCTCGCCCG CTTCTACATC GCAGAGCTGA CTCTGGCCAT TGAGAGTGTG 
CACAAGATGG GCTTCATCCA CAGGGACATC AAGCCTGACA ACATCTTGAT TGACCTGGAT 
GGTCATATTA AGCTGACCGA TTTTGGCCTC TGCACTGGAT TCAGGTGGAC TCACAATTCC 
AAGTACTACC AGAAAGGGAA CCACATCAGA CAGGACAGCA TGGAGCCTGG TGACCTCTGG 
GACGACGTTT CCAACTGTCG TTGTGGAGAC AGGTTGAAGA CCCTGGAGCA GAGAGCACAG 
AAGCAGCACC AGAGGTGCCT GGCACATTCT CTGGTTGGGA CACCAAATTA CATTGCTCCT 
GAGGTGCTTC TTCGCAAAGG GTACACACAG CTCTGTGACT GGTGGAGTGT CGGTGTGATT 
CTTTTTGAGA TGCTGGTTGG GCAGCCACCT TTCTTGGCGC CCACCCCCAC AGAAACCCAG 
CTGAAGGTGA TCAACTGGGA GAACACGCTG CACATCCCTA CGCAGGTGAA ACTCAGTGCT 
GAGGCCCGAG ACCTCATCAC CAAGCTGTGC TGCGCGGCTG ACTGCCGCCT GGGCAGGGAC 
GGGGCAGATG ACCTCAAGGC ACACCCGTTC TTCAGCACCA TCGACTTTTC CCGTGACATC 
CGGAAACAGC CTGCACCCTA CGTCCCCACC ATCAGCCACC CCATGGACAC CTCCAATTTT 
GACCCAGTGG ATGAAGAAAG CCCCTGGCAC GAGGCCAGCG GAGAAAGTGC CAAGGCCTGG 
GACACGCTGG CGTCCCCCAA CAGCAAGCAC CCAGAGCACG CCTTCTATGA GTTCACCTTC 
CGCAGGTTCT TCGACGACAA TGGCTATCCC TTCCGGTGCC CGAAGCCCTC AGAGCCGGCT 
GAGAGTGCAG ACCCAGGGGA TGCAGAGTTA GGAGGTGCGG TCGAGGGCTG CCAGCCAGTG 
TATGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100737.1
CDS	163..3291
Translation	MRPKTFPATTYSGNSRQRLQEIREGLKQPAKSSTQGLLVGPNSDTSSLDAKVLGNKDASRQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLVPTAVTRRPSFEGTGEAFPSHHQLGGANYEGPAALEEMPRQYLDFLFPGASVHGAPAHQHPPKGYSTAVDAGTHFPGAHYGRAHLLSEQPGYGVQRSPSFQSKTPPDTYSSLAKAQGGPPASLTFPAHAGLYTTSHHKPAAAVPGAHPLHVLGTRGPTFTGDSSTQAVLAPSRNSLNNDLYELGSPVPWPAAPLARRDSLQKQSLEASRPHVAFRAGPSRTNSFSSPQPEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPTAPAAAEGLESKEGSAGPPPLDMDFGGSERRCPPPPYPKHLLLPSKSEQYSAGLDRLCTGVEQSLRGGTEQDRNDKGHKGAKGDKAGRDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCETEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPTQVKLSAEARDLITKLCCAADCRLGRDGADDLKAHPFFSTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVDEESPWHEASGESAKAWDTLASPNSKHPEHAFYEFTFRRFFDDNGYPFRCPKPSEPAESADPGDAELGGAVEGCQPVYV

Target ORF information:

RefSeq Version	NM_001107267.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus large tumor suppressor kinase 2 (Lats2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107267.1

ORF Insert Sequence:

ATGAGGCCAA AGACTTTTCC TGCTACAACT TACTCTGGAA ATAGCCGGCA GCGACTGCAA 
GAGATTCGAG AAGGACTGAA GCAGCCGGCC AAGTCTTCCA CCCAGGGGCT GCTGGTGGGA 
CCAAACAGTG ACACTTCTTC CCTGGATGCC AAAGTCCTGG GGAACAAAGA TGCCTCCAGG 
CAGCAGCAGA TGAGAGCCAC CCCGAAGTTT GGACCTTATC AAAAAGCGCT CAGGGAAATC 
CGATATTCCC TCCTGCCTTT TGCCAATGAG TCAGGCACGT CGGCAGCTGC AGAGGTGAAC 
CGGCAGATGC TGCAGGAGTT GGTGAATGCA GGATGTGACC AGGAGATGGC TGGCAGAGCG 
CTCAAGCAGA CAGGCAGTAG GAGTATTGAA GCCGCCTTGG AGTACATCAG TAAGATGGGC 
TACTTGGACC CCAGGAATGA GCAAATTGTG CGAGTCATCA AGCAGACCTC CCCAGGAAAG 
GGCCTGGTGC CCACTGCAGT GACTCGACGA CCCAGCTTTG AGGGCACAGG GGAAGCATTC 
CCATCCCACC ACCAGTTGGG CGGTGCAAAC TATGAGGGCC CCGCTGCCCT GGAGGAGATG 
CCACGGCAAT ATTTAGACTT CCTCTTCCCC GGGGCCAGCG TCCACGGCGC CCCGGCTCAC 
CAGCATCCCC CCAAAGGCTA CAGCACTGCA GTGGATGCGG GCACACACTT CCCAGGCGCA 
CACTATGGTC GTGCTCATCT ACTGTCAGAG CAGCCTGGGT ATGGGGTTCA GCGCAGCCCC 
TCCTTCCAGA GCAAGACGCC ACCAGACACC TATTCCAGCC TGGCCAAGGC CCAGGGTGGC 
CCTCCTGCCA GCCTCACCTT CCCTGCCCAT GCTGGTCTGT ACACCACCTC GCACCACAAG 
CCAGCGGCTG CAGTACCTGG GGCCCACCCC TTACATGTGT TGGGCACCCG GGGCCCCACG 
TTCACTGGGG ACAGCTCTAC GCAGGCCGTT CTGGCACCGT CCAGGAACAG CCTCAATAAT 
GACTTGTACG AGCTGGGCTC TCCCGTGCCC TGGCCCGCAG CTCCACTGGC ACGCCGTGAC 
TCGCTGCAGA AGCAGAGTCT AGAGGCCTCC CGGCCGCATG TGGCCTTCCG GGCTGGGCCC 
AGCAGGACCA ACTCCTTCAG CAGCCCACAA CCTGAGCCCT CACTGCCCGC CCCCAACACA 
GTCACTGCTG TGACGGCTGC ACACATCCTT CACCCTGTGA AGAGCGTGCG CGTGCTGCGG 
CCCGAGCCTC AGACAGCCGT GGGGCCCTCG CACCCCGCCT GGGTGCCTGC CCCCACAGCA 
CCTGCAGCCG CCGAGGGCCT GGAGAGCAAG GAGGGCAGTG CAGGCCCACC CCCGCTGGAT 
ATGGACTTCG GGGGCTCCGA GCGCAGGTGC CCACCGCCTC CTTACCCAAA GCACTTGCTG 
CTGCCCAGTA AGTCTGAGCA GTACAGCGCT GGTCTGGACC GCCTGTGCAC CGGTGTGGAG 
CAGAGTCTGC GCGGGGGCAC CGAGCAAGAC AGGAATGACA AGGGCCACAA GGGTGCTAAG 
GGGGACAAAG CTGGCAGGGA CAAAAAGCAG ATCCAGACCT CCCCAGTGCC TGTCCGCAAG 
AATAGCAGGG ATGAAGAGAA GAGAGAGTCT CGAATCAAGA GTTACTCCCC ATATGCCTTC 
AAATTCTTCA TGGAACAACA TGTGGAGAAT GTCATCAAAA CCTACCAGCA GAAGGTCAGC 
CGGAGGCTAC AGCTGGAGCA GGAAATGGCC AAAGCTGGAC TGTGCGAGAC TGAGCAGGAG 
CAGATGAGGA AGATCCTCTA CCAGAAGGAG TCGAACTACA ACAGACTCAA GAGGGCCAAG 
ATGGACAAGT CCATGTTTGT GAAAATCAAA ACTCTGGGCA TTGGTGCCTT TGGAGAAGTG 
TGCCTTGCCT GTAAGGTGGA TACTCACGCT CTGTATGCCA TGAAGACGCT GAGGAAAAAA 
GATGTCCTGA ACCGGAACCA AGTGGCCCAT GTCAAGGCTG AGAGGGACAT CCTGGCTGAA 
GCAGACAATG AGTGGGTGGT CAAACTCTAC TATTCCTTCC AGGACAAGGA CAGCCTGTAC 
TTTGTGATGG ACTACATACC TGGTGGGGAC ATGATGAGCC TGCTGATCCG GATGGAGGTC 
TTCCCTGAAC ACCTCGCCCG CTTCTACATC GCAGAGCTGA CTCTGGCCAT TGAGAGTGTG 
CACAAGATGG GCTTCATCCA CAGGGACATC AAGCCTGACA ACATCTTGAT TGACCTGGAT 
GGTCATATTA AGCTGACCGA TTTTGGCCTC TGCACTGGAT TCAGGTGGAC TCACAATTCC 
AAGTACTACC AGAAAGGGAA CCACATCAGA CAGGACAGCA TGGAGCCTGG TGACCTCTGG 
GACGACGTTT CCAACTGTCG TTGTGGAGAC AGGTTGAAGA CCCTGGAGCA GAGAGCACAG 
AAGCAGCACC AGAGGTGCCT GGCACATTCT CTGGTTGGGA CACCAAATTA CATTGCTCCT 
GAGGTGCTTC TTCGCAAAGG GTACACACAG CTCTGTGACT GGTGGAGTGT CGGTGTGATT 
CTTTTTGAGA TGCTGGTTGG GCAGCCACCT TTCTTGGCGC CCACCCCCAC AGAAACCCAG 
CTGAAGGTGA TCAACTGGGA GAACACGCTG CACATCCCTA CGCAGGTGAA ACTCAGTGCT 
GAGGCCCGAG ACCTCATCAC CAAGCTGTGC TGCGCGGCTG ACTGCCGCCT GGGCAGGGAC 
GGGGCAGATG ACCTCAAGGC ACACCCGTTC TTCAGCACCA TCGACTTTTC CCGTGACATC 
CGGAAACAGC CTGCACCCTA CGTCCCCACC ATCAGCCACC CCATGGACAC CTCCAATTTT 
GACCCAGTGG ATGAAGAAAG CCCCTGGCAC GAGGCCAGCG GAGAAAGTGC CAAGGCCTGG 
GACACGCTGG CGTCCCCCAA CAGCAAGCAC CCAGAGCACG CCTTCTATGA GTTCACCTTC 
CGCAGGTTCT TCGACGACAA TGGCTATCCC TTCCGGTGCC CGAAGCCCTC AGAGCCGGCT 
GAGAGTGCAG ACCCAGGGGA TGCAGAGTTA GGAGGTGCGG TCGAGGGCTG CCAGCCAGTG 
TATGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lats2 ( XM_008770748.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008768970.1 Rattus norvegicus large tumor suppressor kinase 2 (Lats2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13716
Clone ID Related Accession (Same CDS sequence)	XM_008770748.2 , NM_001107267.1
Accession Version	XM_008770748.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3129bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase LATS2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770748.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCCAA AGACTTTTCC TGCTACAACT TACTCTGGAA ATAGCCGGCA GCGACTGCAA 
GAGATTCGAG AAGGACTGAA GCAGCCGGCC AAGTCTTCCA CCCAGGGGCT GCTGGTGGGA 
CCAAACAGTG ACACTTCTTC CCTGGATGCC AAAGTCCTGG GGAACAAAGA TGCCTCCAGG 
CAGCAGCAGA TGAGAGCCAC CCCGAAGTTT GGACCTTATC AAAAAGCGCT CAGGGAAATC 
CGATATTCCC TCCTGCCTTT TGCCAATGAG TCAGGCACGT CGGCAGCTGC AGAGGTGAAC 
CGGCAGATGC TGCAGGAGTT GGTGAATGCA GGATGTGACC AGGAGATGGC TGGCAGAGCG 
CTCAAGCAGA CAGGCAGTAG GAGTATTGAA GCCGCCTTGG AGTACATCAG TAAGATGGGC 
TACTTGGACC CCAGGAATGA GCAAATTGTG CGAGTCATCA AGCAGACCTC CCCAGGAAAG 
GGCCTGGTGC CCACTGCAGT GACTCGACGA CCCAGCTTTG AGGGCACAGG GGAAGCATTC 
CCATCCCACC ACCAGTTGGG CGGTGCAAAC TATGAGGGCC CCGCTGCCCT GGAGGAGATG 
CCACGGCAAT ATTTAGACTT CCTCTTCCCC GGGGCCAGCG TCCACGGCGC CCCGGCTCAC 
CAGCATCCCC CCAAAGGCTA CAGCACTGCA GTGGATGCGG GCACACACTT CCCAGGCGCA 
CACTATGGTC GTGCTCATCT ACTGTCAGAG CAGCCTGGGT ATGGGGTTCA GCGCAGCCCC 
TCCTTCCAGA GCAAGACGCC ACCAGACACC TATTCCAGCC TGGCCAAGGC CCAGGGTGGC 
CCTCCTGCCA GCCTCACCTT CCCTGCCCAT GCTGGTCTGT ACACCACCTC GCACCACAAG 
CCAGCGGCTG CAGTACCTGG GGCCCACCCC TTACATGTGT TGGGCACCCG GGGCCCCACG 
TTCACTGGGG ACAGCTCTAC GCAGGCCGTT CTGGCACCGT CCAGGAACAG CCTCAATAAT 
GACTTGTACG AGCTGGGCTC TCCCGTGCCC TGGCCCGCAG CTCCACTGGC ACGCCGTGAC 
TCGCTGCAGA AGCAGAGTCT AGAGGCCTCC CGGCCGCATG TGGCCTTCCG GGCTGGGCCC 
AGCAGGACCA ACTCCTTCAG CAGCCCACAA CCTGAGCCCT CACTGCCCGC CCCCAACACA 
GTCACTGCTG TGACGGCTGC ACACATCCTT CACCCTGTGA AGAGCGTGCG CGTGCTGCGG 
CCCGAGCCTC AGACAGCCGT GGGGCCCTCG CACCCCGCCT GGGTGCCTGC CCCCACAGCA 
CCTGCAGCCG CCGAGGGCCT GGAGAGCAAG GAGGGCAGTG CAGGCCCACC CCCGCTGGAT 
ATGGACTTCG GGGGCTCCGA GCGCAGGTGC CCACCGCCTC CTTACCCAAA GCACTTGCTG 
CTGCCCAGTA AGTCTGAGCA GTACAGCGCT GGTCTGGACC GCCTGTGCAC CGGTGTGGAG 
CAGAGTCTGC GCGGGGGCAC CGAGCAAGAC AGGAATGACA AGGGCCACAA GGGTGCTAAG 
GGGGACAAAG CTGGCAGGGA CAAAAAGCAG ATCCAGACCT CCCCAGTGCC TGTCCGCAAG 
AATAGCAGGG ATGAAGAGAA GAGAGAGTCT CGAATCAAGA GTTACTCCCC ATATGCCTTC 
AAATTCTTCA TGGAACAACA TGTGGAGAAT GTCATCAAAA CCTACCAGCA GAAGGTCAGC 
CGGAGGCTAC AGCTGGAGCA GGAAATGGCC AAAGCTGGAC TGTGCGAGAC TGAGCAGGAG 
CAGATGAGGA AGATCCTCTA CCAGAAGGAG TCGAACTACA ACAGACTCAA GAGGGCCAAG 
ATGGACAAGT CCATGTTTGT GAAAATCAAA ACTCTGGGCA TTGGTGCCTT TGGAGAAGTG 
TGCCTTGCCT GTAAGGTGGA TACTCACGCT CTGTATGCCA TGAAGACGCT GAGGAAAAAA 
GATGTCCTGA ACCGGAACCA AGTGGCCCAT GTCAAGGCTG AGAGGGACAT CCTGGCTGAA 
GCAGACAATG AGTGGGTGGT CAAACTCTAC TATTCCTTCC AGGACAAGGA CAGCCTGTAC 
TTTGTGATGG ACTACATACC TGGTGGGGAC ATGATGAGCC TGCTGATCCG GATGGAGGTC 
TTCCCTGAAC ACCTCGCCCG CTTCTACATC GCAGAGCTGA CTCTGGCCAT TGAGAGTGTG 
CACAAGATGG GCTTCATCCA CAGGGACATC AAGCCTGACA ACATCTTGAT TGACCTGGAT 
GGTCATATTA AGCTGACCGA TTTTGGCCTC TGCACTGGAT TCAGGTGGAC TCACAATTCC 
AAGTACTACC AGAAAGGGAA CCACATCAGA CAGGACAGCA TGGAGCCTGG TGACCTCTGG 
GACGACGTTT CCAACTGTCG TTGTGGAGAC AGGTTGAAGA CCCTGGAGCA GAGAGCACAG 
AAGCAGCACC AGAGGTGCCT GGCACATTCT CTGGTTGGGA CACCAAATTA CATTGCTCCT 
GAGGTGCTTC TTCGCAAAGG GTACACACAG CTCTGTGACT GGTGGAGTGT CGGTGTGATT 
CTTTTTGAGA TGCTGGTTGG GCAGCCACCT TTCTTGGCGC CCACCCCCAC AGAAACCCAG 
CTGAAGGTGA TCAACTGGGA GAACACGCTG CACATCCCTA CGCAGGTGAA ACTCAGTGCT 
GAGGCCCGAG ACCTCATCAC CAAGCTGTGC TGCGCGGCTG ACTGCCGCCT GGGCAGGGAC 
GGGGCAGATG ACCTCAAGGC ACACCCGTTC TTCAGCACCA TCGACTTTTC CCGTGACATC 
CGGAAACAGC CTGCACCCTA CGTCCCCACC ATCAGCCACC CCATGGACAC CTCCAATTTT 
GACCCAGTGG ATGAAGAAAG CCCCTGGCAC GAGGCCAGCG GAGAAAGTGC CAAGGCCTGG 
GACACGCTGG CGTCCCCCAA CAGCAAGCAC CCAGAGCACG CCTTCTATGA GTTCACCTTC 
CGCAGGTTCT TCGACGACAA TGGCTATCCC TTCCGGTGCC CGAAGCCCTC AGAGCCGGCT 
GAGAGTGCAG ACCCAGGGGA TGCAGAGTTA GGAGGTGCGG TCGAGGGCTG CCAGCCAGTG 
TATGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008768970.1
CDS	214..3342
Translation	MRPKTFPATTYSGNSRQRLQEIREGLKQPAKSSTQGLLVGPNSDTSSLDAKVLGNKDASRQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLVPTAVTRRPSFEGTGEAFPSHHQLGGANYEGPAALEEMPRQYLDFLFPGASVHGAPAHQHPPKGYSTAVDAGTHFPGAHYGRAHLLSEQPGYGVQRSPSFQSKTPPDTYSSLAKAQGGPPASLTFPAHAGLYTTSHHKPAAAVPGAHPLHVLGTRGPTFTGDSSTQAVLAPSRNSLNNDLYELGSPVPWPAAPLARRDSLQKQSLEASRPHVAFRAGPSRTNSFSSPQPEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPTAPAAAEGLESKEGSAGPPPLDMDFGGSERRCPPPPYPKHLLLPSKSEQYSAGLDRLCTGVEQSLRGGTEQDRNDKGHKGAKGDKAGRDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCETEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPTQVKLSAEARDLITKLCCAADCRLGRDGADDLKAHPFFSTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVDEESPWHEASGESAKAWDTLASPNSKHPEHAFYEFTFRRFFDDNGYPFRCPKPSEPAESADPGDAELGGAVEGCQPVYV

Target ORF information:

RefSeq Version	XM_008770748.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus large tumor suppressor kinase 2 (Lats2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008770748.2

ORF Insert Sequence:

ATGAGGCCAA AGACTTTTCC TGCTACAACT TACTCTGGAA ATAGCCGGCA GCGACTGCAA 
GAGATTCGAG AAGGACTGAA GCAGCCGGCC AAGTCTTCCA CCCAGGGGCT GCTGGTGGGA 
CCAAACAGTG ACACTTCTTC CCTGGATGCC AAAGTCCTGG GGAACAAAGA TGCCTCCAGG 
CAGCAGCAGA TGAGAGCCAC CCCGAAGTTT GGACCTTATC AAAAAGCGCT CAGGGAAATC 
CGATATTCCC TCCTGCCTTT TGCCAATGAG TCAGGCACGT CGGCAGCTGC AGAGGTGAAC 
CGGCAGATGC TGCAGGAGTT GGTGAATGCA GGATGTGACC AGGAGATGGC TGGCAGAGCG 
CTCAAGCAGA CAGGCAGTAG GAGTATTGAA GCCGCCTTGG AGTACATCAG TAAGATGGGC 
TACTTGGACC CCAGGAATGA GCAAATTGTG CGAGTCATCA AGCAGACCTC CCCAGGAAAG 
GGCCTGGTGC CCACTGCAGT GACTCGACGA CCCAGCTTTG AGGGCACAGG GGAAGCATTC 
CCATCCCACC ACCAGTTGGG CGGTGCAAAC TATGAGGGCC CCGCTGCCCT GGAGGAGATG 
CCACGGCAAT ATTTAGACTT CCTCTTCCCC GGGGCCAGCG TCCACGGCGC CCCGGCTCAC 
CAGCATCCCC CCAAAGGCTA CAGCACTGCA GTGGATGCGG GCACACACTT CCCAGGCGCA 
CACTATGGTC GTGCTCATCT ACTGTCAGAG CAGCCTGGGT ATGGGGTTCA GCGCAGCCCC 
TCCTTCCAGA GCAAGACGCC ACCAGACACC TATTCCAGCC TGGCCAAGGC CCAGGGTGGC 
CCTCCTGCCA GCCTCACCTT CCCTGCCCAT GCTGGTCTGT ACACCACCTC GCACCACAAG 
CCAGCGGCTG CAGTACCTGG GGCCCACCCC TTACATGTGT TGGGCACCCG GGGCCCCACG 
TTCACTGGGG ACAGCTCTAC GCAGGCCGTT CTGGCACCGT CCAGGAACAG CCTCAATAAT 
GACTTGTACG AGCTGGGCTC TCCCGTGCCC TGGCCCGCAG CTCCACTGGC ACGCCGTGAC 
TCGCTGCAGA AGCAGAGTCT AGAGGCCTCC CGGCCGCATG TGGCCTTCCG GGCTGGGCCC 
AGCAGGACCA ACTCCTTCAG CAGCCCACAA CCTGAGCCCT CACTGCCCGC CCCCAACACA 
GTCACTGCTG TGACGGCTGC ACACATCCTT CACCCTGTGA AGAGCGTGCG CGTGCTGCGG 
CCCGAGCCTC AGACAGCCGT GGGGCCCTCG CACCCCGCCT GGGTGCCTGC CCCCACAGCA 
CCTGCAGCCG CCGAGGGCCT GGAGAGCAAG GAGGGCAGTG CAGGCCCACC CCCGCTGGAT 
ATGGACTTCG GGGGCTCCGA GCGCAGGTGC CCACCGCCTC CTTACCCAAA GCACTTGCTG 
CTGCCCAGTA AGTCTGAGCA GTACAGCGCT GGTCTGGACC GCCTGTGCAC CGGTGTGGAG 
CAGAGTCTGC GCGGGGGCAC CGAGCAAGAC AGGAATGACA AGGGCCACAA GGGTGCTAAG 
GGGGACAAAG CTGGCAGGGA CAAAAAGCAG ATCCAGACCT CCCCAGTGCC TGTCCGCAAG 
AATAGCAGGG ATGAAGAGAA GAGAGAGTCT CGAATCAAGA GTTACTCCCC ATATGCCTTC 
AAATTCTTCA TGGAACAACA TGTGGAGAAT GTCATCAAAA CCTACCAGCA GAAGGTCAGC 
CGGAGGCTAC AGCTGGAGCA GGAAATGGCC AAAGCTGGAC TGTGCGAGAC TGAGCAGGAG 
CAGATGAGGA AGATCCTCTA CCAGAAGGAG TCGAACTACA ACAGACTCAA GAGGGCCAAG 
ATGGACAAGT CCATGTTTGT GAAAATCAAA ACTCTGGGCA TTGGTGCCTT TGGAGAAGTG 
TGCCTTGCCT GTAAGGTGGA TACTCACGCT CTGTATGCCA TGAAGACGCT GAGGAAAAAA 
GATGTCCTGA ACCGGAACCA AGTGGCCCAT GTCAAGGCTG AGAGGGACAT CCTGGCTGAA 
GCAGACAATG AGTGGGTGGT CAAACTCTAC TATTCCTTCC AGGACAAGGA CAGCCTGTAC 
TTTGTGATGG ACTACATACC TGGTGGGGAC ATGATGAGCC TGCTGATCCG GATGGAGGTC 
TTCCCTGAAC ACCTCGCCCG CTTCTACATC GCAGAGCTGA CTCTGGCCAT TGAGAGTGTG 
CACAAGATGG GCTTCATCCA CAGGGACATC AAGCCTGACA ACATCTTGAT TGACCTGGAT 
GGTCATATTA AGCTGACCGA TTTTGGCCTC TGCACTGGAT TCAGGTGGAC TCACAATTCC 
AAGTACTACC AGAAAGGGAA CCACATCAGA CAGGACAGCA TGGAGCCTGG TGACCTCTGG 
GACGACGTTT CCAACTGTCG TTGTGGAGAC AGGTTGAAGA CCCTGGAGCA GAGAGCACAG 
AAGCAGCACC AGAGGTGCCT GGCACATTCT CTGGTTGGGA CACCAAATTA CATTGCTCCT 
GAGGTGCTTC TTCGCAAAGG GTACACACAG CTCTGTGACT GGTGGAGTGT CGGTGTGATT 
CTTTTTGAGA TGCTGGTTGG GCAGCCACCT TTCTTGGCGC CCACCCCCAC AGAAACCCAG 
CTGAAGGTGA TCAACTGGGA GAACACGCTG CACATCCCTA CGCAGGTGAA ACTCAGTGCT 
GAGGCCCGAG ACCTCATCAC CAAGCTGTGC TGCGCGGCTG ACTGCCGCCT GGGCAGGGAC 
GGGGCAGATG ACCTCAAGGC ACACCCGTTC TTCAGCACCA TCGACTTTTC CCGTGACATC 
CGGAAACAGC CTGCACCCTA CGTCCCCACC ATCAGCCACC CCATGGACAC CTCCAATTTT 
GACCCAGTGG ATGAAGAAAG CCCCTGGCAC GAGGCCAGCG GAGAAAGTGC CAAGGCCTGG 
GACACGCTGG CGTCCCCCAA CAGCAAGCAC CCAGAGCACG CCTTCTATGA GTTCACCTTC 
CGCAGGTTCT TCGACGACAA TGGCTATCCC TTCCGGTGCC CGAAGCCCTC AGAGCCGGCT 
GAGAGTGCAG ACCCAGGGGA TGCAGAGTTA GGAGGTGCGG TCGAGGGCTG CCAGCCAGTG 
TATGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation.
Genes & development27(13)1441-6(2013 Jul)
Lorthongpanich C,Messerschmidt DM,Chan SW,Hong W,Knowles BB,Solter D

MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2.
The Journal of biological chemistry286(49)42371-80(2011 Dec)
Liu X,Cheng Y,Chen X,Yang J,Xu L,Zhang C

Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.
Science (New York, N.Y.)332(6028)458-61(2011 Apr)
Heallen T,Zhang M,Wang J,Bonilla-Claudio M,Klysik E,Johnson RL,Martin JF

The Hippo pathway regulates Wnt/beta-catenin signaling.
Developmental cell18(4)579-91(2010 Apr)
Varelas X,Miller BW,Sopko R,Song S,Gregorieff A,Fellouse FA,Sakuma R,Pawson T,Hunziker W,McNeill H,Wrana JL,Attisano L

The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.
Developmental cell16(3)398-410(2009 Mar)
Nishioka N,Inoue K,Adachi K,Kiyonari H,Ota M,Ralston A,Yabuta N,Hirahara S,Stephenson RO,Ogonuki N,Makita R,Kurihara H,Morin-Kensicki EM,Nojima H,Rossant J,Nakao K,Niwa H,Sasaki H

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Lats2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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