| Gene Symbol | Tmbim1 |
| Entrez Gene ID | 69660 |
| Full Name | transmembrane BAX inhibitor motif containing 1 |
| Synonyms | 2310061B02Rik,AA960455,AU024746,C78899,RECS1,Tmbib1,mKIAA4161 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Tmbim1 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Tmbim1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tmbim1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu03731 Clone ID Related Accession (Same CDS sequence) NM_027154.5 Accession Version NM_027154.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 930bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577376000000 Organism Mus musculus(house mouse) Product protein lifeguard 3 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY312755.1, AK152864.1 and BQ031095.1. On May 7, 2009 this sequence version replaced NM_027154.4. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.45386.1, SRR1660813.139961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGTCCAATC CCAGTGCCCC ACCTCCCTAT GAGGACCACA ACCCCCTGTA CCCTGGCTCT
CCACCTCCTG GTGGCTACGG GCAGCCATCT GTCCTGCCAG GTGGTTATCC CGCCTACCCT
GCCTACCCTC AACCTGGTTA CGGTCATCCT GCTGGCTACC CACAGCCGGT TCCTCCCGTC
CATCCAATGC CCATGAACTA CGGCCATGAC TATAATGAAG AGGAGAGAGC AGGAAGTGAC
AGCTTTCGTC CTGGAGAATG GGATGACCGG AAAGTTCGAC ATTCCTTCAT CCAAAAGGTG
TATTGCATCA TTTCTGTCCA GCTGCTCATC ACTGTGGCCA TCATTGCAAT CTTCACCTTT
GTGGAACCAG TCGGCAAATA CGTGAGGAAC AATGTGGCTG TGTACTACGT GTCCTATGCT
GTCTTCCTTG TCACCTACCT GACCCTTGCC TGCTGCCAGG GACCCAGGCG CCGATTCCCA
TGGAACATCA TCTTGCTCAC CATCTTTACT TTGGCTTTGG GCTTTGTGAC AGGCACTATT
TCCAGTATGT ATGAAACCAA AGCTGTCATC ATAGCAATGA TCATCACCGC TGTGGTATCC
ATCTCTGTCA CCATCTTCTG CTTTCAGACT AAGGTGGACT TCACCTCGTG TACAGGCCTC
TTCTGTGTGC TGGGAATAGT GCTGATGGTG ACCGGAATTG TCACAAGCAT AGTGCTGATC
TTTAAATATA TTTACTGGCT CCACATGGTC TATGCAGCTC TGGGGGCCAT CTGTTTCACC
CTGTTCCTGG CTTATGACAC ACAGCTGGTC CTGGGGAACC GGAAGCACAC CATCAGCCCG
GAGGACTACA TCACAGGCGC CCTACAGATC TACACAGATA TAGTCTATAT CTTCACGTTC
GTGCTCCAGC TCGTAGGAAG TAGAGACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_081430.3 CDS 255..1184 Translation 
Target ORF information:
RefSeq Version NM_027154.5 Organism Mus musculus(house mouse) Definition Mus musculus transmembrane BAX inhibitor motif containing 1 (Tmbim1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_027154.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGTCCAATC CCAGTGCCCC ACCTCCCTAT GAGGACCACA ACCCCCTGTA CCCTGGCTCT
CCACCTCCTG GTGGCTACGG GCAGCCATCT GTCCTGCCAG GTGGTTATCC CGCCTACCCT
GCCTACCCTC AACCTGGTTA CGGTCATCCT GCTGGCTACC CACAGCCGGT TCCTCCCGTC
CATCCAATGC CCATGAACTA CGGCCATGAC TATAATGAAG AGGAGAGAGC AGGAAGTGAC
AGCTTTCGTC CTGGAGAATG GGATGACCGG AAAGTTCGAC ATTCCTTCAT CCAAAAGGTG
TATTGCATCA TTTCTGTCCA GCTGCTCATC ACTGTGGCCA TCATTGCAAT CTTCACCTTT
GTGGAACCAG TCGGCAAATA CGTGAGGAAC AATGTGGCTG TGTACTACGT GTCCTATGCT
GTCTTCCTTG TCACCTACCT GACCCTTGCC TGCTGCCAGG GACCCAGGCG CCGATTCCCA
TGGAACATCA TCTTGCTCAC CATCTTTACT TTGGCTTTGG GCTTTGTGAC AGGCACTATT
TCCAGTATGT ATGAAACCAA AGCTGTCATC ATAGCAATGA TCATCACCGC TGTGGTATCC
ATCTCTGTCA CCATCTTCTG CTTTCAGACT AAGGTGGACT TCACCTCGTG TACAGGCCTC
TTCTGTGTGC TGGGAATAGT GCTGATGGTG ACCGGAATTG TCACAAGCAT AGTGCTGATC
TTTAAATATA TTTACTGGCT CCACATGGTC TATGCAGCTC TGGGGGCCAT CTGTTTCACC
CTGTTCCTGG CTTATGACAC ACAGCTGGTC CTGGGGAACC GGAAGCACAC CATCAGCCCG
GAGGACTACA TCACAGGCGC CCTACAGATC TACACAGATA TAGTCTATAT CTTCACGTTC
GTGCTCCAGC TCGTAGGAAG TAGAGACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Up regulated Tmbim1 activation promotes high fat diet (HFD)-induced cardiomyopathy by enhancement of inflammation and oxidative stress.
Biochemical and biophysical research communications504(4)797-804(2018 10)
Gong F,Gu J,Wang H
Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4.
Nature medicine23(6)742-752(2017 Jun)
Zhao GN,Zhang P,Gong J,Zhang XJ,Wang PX,Yin M,Jiang Z,Shen LJ,Ji YX,Tong J,Wang Y,Wei QF,Wang Y,Zhu XY,Zhang X,Fang J,Xie Q,She ZG,Wang Z,Huang Z,Li H
RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation.
Circulation journal : official journal of the Japanese Circulation Society70(5)615-24(2006 May)
Zhao H,Ito A,Sakai N,Matsuzawa Y,Yamashita S,Nojima H
RECS1 deficiency in mice induces susceptibility to cystic medial degeneration.
Genes & genetic systems81(1)41-50(2006 Feb)
Zhao H,Ito A,Kimura SH,Yabuta N,Sakai N,Ikawa M,Okabe M,Matsuzawa Y,Yamashita S,Nojima H
Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library.
Atherosclerosis162(2)323-34(2002 Jun)
Yoshisue H,Suzuki K,Kawabata A,Ohya T,Zhao H,Sakurada K,Taba Y,Sasaguri T,Sakai N,Yamashita S,Matsuzawa Y,Nojima H
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