Developing novel nanostructures for improved
immunotherapy responses with GenScript’s long peptides

Throughout his training, Dr. Sergej Kudruk has been deeply involved in cutting-edge research across diverse scientific areas, including the interdisciplinary field of biomaterials. His primary focus has involved the development of innovative nanotherapeutics tailored for the treatment of cancer and neurodegenerative diseases.

By understanding the intricacies of how nanocarriers behave within these pathophysiological conditions, Kudruk aims to contribute to the advancement of targeted drug delivery systems and enhance our understanding of the potential applications of nanotechnology in medicine.

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GenScript delivered great service with their high-speed production capabilities of round-the-clock responsiveness, which played a crucial role in expediting our project.

- Sergej Kudruk , Northwestern University

Project’s Critical Challenge

As an International Institute for Nanotechnology (IIN) Postdoctoral Fellow in Dr. Chad A. Mirkin’s lab at Northwestern University, Sergej Kudruk is currently focusing on modularity of nanoscale architecture to activate and enhance the patient's immune system in the fight against diseases. Where nanomedicines are defined not just by the identity of the active components but also by their structural arrangement and chemical connectivity.  By identifying the structural determinants that contribute to improved immune responses against cancer cells, Kudruk aims to optimize nanoimmunotherapeutics for precise and efficient tumor targeting.

A significant challenge in his current project is the need for long synthetic peptide epitopes to achieve specific nanostructure modifications. Screening a wide spectrum of long peptide epitopes required peptide scalability within a reasonable timeframe, making outsourcing a necessity.