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selfish gene

DNA that functions to propagate itself to the detriment of other DNA sequences of the genome; e.g. a DNA that encodes an endonuclease that specifically cleaves an allele that does not contain the nuclease gene, and allows conversion of the heterozygous cell into a homozygous cell that contains the selfish DNA, or a lethal or detrimental gene that persists during the evolution of an organism, perhaps due to its close linkage to essential genes. Grivell, L.A. (1992) Curr. Biol. 2, 450-452; Bull, J.J., Molineux, I.J. and Werren, J.H. (1992) Science 256, 65

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