Advancing Cell Therapies with Non-Viral CRISPR

Gene and cell therapies can provide curative solutions to a broad range of diseases, from rare monogenic disorders to numerous cancer indications. Enabled by CRISPR/Cas9 genome editing tools, gene and cell modifications may be achieved with exquisite precision ensuring effective and safe therapies. In addition, the development of new tools, resources, and methodologies supporting fully non-viral CRISPR/Cas9-based editing is empowering investigators beyond large pharma to expedite the next generation of gene and cell therapies.

From CRISPR/Cas9 fundamental mechanisms to the tools and methods enabling today’s non-viral CRISPR/Cas9 mediated insertions of large synthetic gene sequences. This e-book provides:

• Overview of advances in CRISPR/Cas9 genome editing
• Non-viral approaches improving knockin efficiency
• Engineering T cells with non-viral CRISPR
• Latest synthetic DNA designs enabling efficient homology directed repair

Additionally, you will find helpful webinars, case studies, and protocols to ease your transition into non-viral CRISPR/Cas9 based genome editing.