Class I MHC mediated antigen processing
Homo sapiens (human) Class I MHC mediated antigen processing & presentation (provided by Reactome)
About the Class I MHC mediated antigen processing & presentation pathway
Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
268 gene
| Gene Symbol | Full Name |
|---|---|
| B2M | beta-2-microglobulin |
| BLMH | bleomycin hydrolase |
| CALR | calreticulin |
| CANX | calnexin |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CD36 | CD36 molecule (thrombospondin receptor) |
| CDC20 | cell division cycle 20 |
| CDC27 | cell division cycle 27 |
| CDC34 | cell division cycle 34 |
| CTSL | cathepsin L |
| CTSV | cathepsin V |
| CTSS | cathepsin S |
| CYBA | cytochrome b-245, alpha polypeptide |
| CYBB | cytochrome b-245, beta polypeptide |
| FCGR1A | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
| FCGR1B | Fc fragment of IgG, high affinity Ib, receptor (CD64) |
| PDIA3 | protein disulfide isomerase family A, member 3 |
| UBE2K | ubiquitin-conjugating enzyme E2K |
| HLA-A | major histocompatibility complex, class I, A |
| HLA-B | major histocompatibility complex, class I, B |
| HLA-C | major histocompatibility complex, class I, C |
| HLA-E | major histocompatibility complex, class I, E |
| HLA-F | major histocompatibility complex, class I, F |
| HLA-G | major histocompatibility complex, class I, G |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
| ITGAV | integrin, alpha V |
| ITGB5 | integrin, beta 5 |
| LNPEP | leucyl/cystinyl aminopeptidase |
| MRC1 | mannose receptor, C type 1 |
| TRIM37 | tripartite motif containing 37 |
| NCF2 | neutrophil cytosolic factor 2 |
| NCF4 | neutrophil cytosolic factor 4, 40kDa |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase |
| PARK2 | parkin RBR E3 ubiquitin protein ligase |
| PSMA1 | proteasome subunit alpha 1 |
| PSMA2 | proteasome subunit alpha 2 |
| PSMA3 | proteasome subunit alpha 3 |
| PSMA4 | proteasome subunit alpha 4 |
| PSMA5 | proteasome subunit alpha 5 |
| PSMA6 | proteasome subunit alpha 6 |
| PSMA7 | proteasome subunit alpha 7 |
| PSMB1 | proteasome subunit beta 1 |
| PSMB2 | proteasome subunit beta 2 |
| PSMB3 | proteasome subunit beta 3 |
| PSMB4 | proteasome subunit beta 4 |
| PSMB5 | proteasome subunit beta 5 |
| PSMB6 | proteasome subunit beta 6 |
| PSMB7 | proteasome subunit beta 7 |
| PSMB8 | proteasome subunit beta 8 |
| PSMB9 | proteasome subunit beta 9 |
| PSMB10 | proteasome subunit beta 10 |
| PSMC1 | proteasome 26S subunit, ATPase 1 |
| PSMC2 | proteasome 26S subunit, ATPase 2 |
| PSMC3 | proteasome 26S subunit, ATPase 3 |
| PSMC4 | proteasome 26S subunit, ATPase 4 |
| PSMC5 | proteasome 26S subunit, ATPase 5 |
| PSMC6 | proteasome 26S subunit, ATPase 6 |
| PSMD1 | proteasome 26S subunit, non-ATPase 1 |
| PSMD2 | proteasome 26S subunit, non-ATPase 2 |
| PSMD3 | proteasome 26S subunit, non-ATPase 3 |
| PSMD4 | proteasome 26S subunit, non-ATPase 4 |
| PSMD5 | proteasome 26S subunit, non-ATPase 5 |
| PSMD7 | proteasome 26S subunit, non-ATPase 7 |
| PSMD8 | proteasome 26S subunit, non-ATPase 8 |
| PSMD9 | proteasome 26S subunit, non-ATPase 9 |
| PSMD10 | proteasome 26S subunit, non-ATPase 10 |
| PSMD11 | proteasome 26S subunit, non-ATPase 11 |
| PSMD12 | proteasome 26S subunit, non-ATPase 12 |
| PSMD13 | proteasome 26S subunit, non-ATPase 13 |
| PSME1 | proteasome activator subunit 1 |
| PSME2 | proteasome activator subunit 2 |
| RNF4 | ring finger protein 4 |
| RNF6 | ring finger protein (C3H2C3 type) 6 |
| RPS27A | ribosomal protein S27a |
| SEC13 | SEC13 homolog, nuclear pore and COPII coat complex component |
| SKP1 | S-phase kinase-associated protein 1 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| TRIM21 | tripartite motif containing 21 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
| TAP2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
| TAPBP | TAP binding protein (tapasin) |
| TCEB1 | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) |
| TCEB2 | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) |
| TPP2 | tripeptidyl peptidase II |
| UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 |
| UBB | ubiquitin B |
| UBC | ubiquitin C |
| UBA1 | ubiquitin-like modifier activating enzyme 1 |
| UBA7 | ubiquitin-like modifier activating enzyme 7 |
| UBE2A | ubiquitin-conjugating enzyme E2A |
| UBE2B | ubiquitin-conjugating enzyme E2B |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 |
| UBE2H | ubiquitin-conjugating enzyme E2H |
| UBE2L3 | ubiquitin-conjugating enzyme E2L 3 |
