Engineering protease-activatable adeno-associated virus (AAV) for targeted delivery through library design

Adeno-Associated Viruses (AAVs) have been a prevalent platform for gene delivery due to their simple structure and genome, lack of pathogenicity, and low immunogenicity. However, like other viral vectors, AAV's transduction pathway is dictated by the natural tropism of the capsid. As such, a significant portion of AAV research has covered mutating the naturally occurring AAV capsids to create unique capsid sequences by replacing or adding sequence elements to alter the capsid's tropism to target specific organs or sites of disease, such as cancer.

This webinar will focus on the development and use of protease-activatable AAV vectors, known as provectors, to target sites of enzyme over-expression such as matrix metalloproteases (MMPs). We will discuss how, through the use of precisely created mutant libraries, we can optimize the ON state of provectors to enhance transduction efficiency and improve targeted delivery.

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Engineering protease-activatable adeno-associated virus (AAV) for targeted delivery through library design

Adeno-Associated Viruses (AAVs) have been a prevalent platform for gene delivery due to their simple structure and genome, lack of pathogenicity, and low immunogenicity.

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