Cxcl12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcl12
Entrez Gene ID	24772
Full Name	C-X-C motif chemokine ligand 12
Synonyms	Sdf1
General protein information	Preferred Names C-X-C motif chemokine ligand 12 Names stromal cell-derived factor 1 SDF-1 gamma chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) stromal cell-derived factor-1 gamma
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	a chemoattractant molecule; involved in cell migration [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033882.1	NP_001029054.1	stromal cell-derived factor 1 isoform beta
NM_001033883.1	NP_001029055.1	stromal cell-derived factor 1 isoform gamma
NM_022177.3	NP_071513.1	stromal cell-derived factor 1 isoform alpha

Pathways from BioSystems

Homologies

Homo sapiens (human)	CXCL12	NP_001171605.1
Rattus norvegicus (Norway rat)	Cxcl12	NP_001029055.1
Mus musculus (house mouse)	Cxcl12	NP_001012495.1
Gallus gallus (chicken)	CXCL12	NP_989841.1
Bos taurus (cattle)	CXCL12	NP_001106645.1
Pan troglodytes (chimpanzee)	LOC741624	XP_001157443.2
Macaca mulatta (Rhesus monkey)	CXCL12	NP_001028106.1
Canis lupus familiaris (dog)	CXCL12	NP_001121569.1
Xenopus tropicalis (tropical clawed frog)	cxcl12	NP_001015764.1

Gene Ontology
Bibliography

Related articles in PubMed

Annexin 1 inhibits remifentanil-induced hyperalgesia and NMDA receptor phosphorylation via regulating spinal CXCL12/CXCR4 in rats.
Li T, Wang H, Wang J, Chen Y, Yang C, Zhao M, Wang G, Yang Z
Neuroscience research14448-55(2019 Jul)

CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway.
Gao D, Tang T, Zhu J, Tang Y, Sun H, Li S
International journal of biological macromolecules124460-468(2019 Mar)

Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway.
Huang X, Mao W, Zhang T, Wang M, Wang X, Li Y, Zhang L, Yao D, Cai X, Wang L
BMC complementary and alternative medicine18(1)330(2018 Dec)

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways.
Tian Y, Yin H, Deng X, Tang B, Ren X, Jiang T
Molecular medicine reports18(5)4374-4380(2018 Nov)

Epigenetic upregulation of CXCL12 expression contributes to the acquisition and maintenance of morphine-induced conditioned place preference.
Liu H, Wei J, Liu M, Wu S, Ma C, Liu C, Huang K, Zhang X, Guo R, Zhang K, Xin W
Experimental neurology30655-63(2018 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cxcl12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcl12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa12892	NM_022177.3 Latest version!	Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
ORa12953	NM_001033882.1 Latest version!	Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
ORa12963	NM_001033883.1 Latest version!	Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcl12 ( NM_022177.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071513.1 Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa12892
Clone ID Related Accession (Same CDS sequence)	NM_022177.3
Accession Version	NM_022177.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575648000000
Organism	Rattus norvegicus(Norway rat)
Product	stromal cell-derived factor 1 isoform alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK475409.1, BC078737.1 and AF209976.1. On Sep 28, 2005 this sequence version replaced NM_022177.2. Transcript Variant: This variant (1) encodes the isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF209976.1, BC078737.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACGCCA AGGTCGTCGC CGTGCTGGCC CTGGTGCTGG CCGCGCTCTG CATCAGTGAC 
GGTAAGCCAG TCAGCCTGAG CTACAGATGC CCCTGCCGAT TCTTTGAGAG CCATGTCGCC 
AGAGCCAACG TCAAACATCT GAAAATCCTC AACACTCCAA ACTGTGCCCT TCAGATTGTT 
GCAAGGCTGA AAAGCAACAA CAGACAAGTG TGCATTGACC CGAAATTAAA GTGGATCCAA 
GAGTACCTGG ACAAAGCCTT AAACAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071513.1
CDS	82..351
Translation	MDAKVVAVLALVLAALCISDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKSNNRQVCIDPKLKWIQEYLDKALNK

Target ORF information:

RefSeq Version	NM_022177.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022177.3

ORF Insert Sequence:

ATGGACGCCA AGGTCGTCGC CGTGCTGGCC CTGGTGCTGG CCGCGCTCTG CATCAGTGAC 
GGTAAGCCAG TCAGCCTGAG CTACAGATGC CCCTGCCGAT TCTTTGAGAG CCATGTCGCC 
AGAGCCAACG TCAAACATCT GAAAATCCTC AACACTCCAA ACTGTGCCCT TCAGATTGTT 
GCAAGGCTGA AAAGCAACAA CAGACAAGTG TGCATTGACC CGAAATTAAA GTGGATCCAA 
GAGTACCTGG ACAAAGCCTT AAACAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cxcl12 ( NM_001033882.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029054.1 Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa12953
Clone ID Related Accession (Same CDS sequence)	NM_001033882.1
Accession Version	NM_001033882.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575648000000
Organism	Rattus norvegicus(Norway rat)
Product	stromal cell-derived factor 1 isoform beta
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK475409.1, CV081127.1 and AABR07061848.1. Transcript Variant: This variant (2) lacks an internal exon and uses an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. It encodes isoform beta which is longer and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ092707.1, CO570174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACGCCA AGGTCGTCGC CGTGCTGGCC CTGGTGCTGG CCGCGCTCTG CATCAGTGAC 
GGTAAGCCAG TCAGCCTGAG CTACAGATGC CCCTGCCGAT TCTTTGAGAG CCATGTCGCC 
AGAGCCAACG TCAAACATCT GAAAATCCTC AACACTCCAA ACTGTGCCCT TCAGATTGTT 
GCAAGGCTGA AAAGCAACAA CAGACAAGTG TGCATTGACC CGAAATTAAA GTGGATCCAA 
GAGTACCTGG ACAAAGCCTT AAACAAGAGG CTCAAGATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029054.1
CDS	82..363
Translation	MDAKVVAVLALVLAALCISDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKSNNRQVCIDPKLKWIQEYLDKALNKRLKM

Target ORF information:

RefSeq Version	NM_001033882.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033882.1

ORF Insert Sequence:

ATGGACGCCA AGGTCGTCGC CGTGCTGGCC CTGGTGCTGG CCGCGCTCTG CATCAGTGAC 
GGTAAGCCAG TCAGCCTGAG CTACAGATGC CCCTGCCGAT TCTTTGAGAG CCATGTCGCC 
AGAGCCAACG TCAAACATCT GAAAATCCTC AACACTCCAA ACTGTGCCCT TCAGATTGTT 
GCAAGGCTGA AAAGCAACAA CAGACAAGTG TGCATTGACC CGAAATTAAA GTGGATCCAA 
GAGTACCTGG ACAAAGCCTT AAACAAGAGG CTCAAGATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cxcl12 ( NM_001033883.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029055.1 Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12), transcript variant 3, mRNA.

Price & Availability↑

CloneID	ORa12963
Clone ID Related Accession (Same CDS sequence)	NM_001033883.1
Accession Version	NM_001033883.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575648000000
Organism	Rattus norvegicus(Norway rat)
Product	stromal cell-derived factor 1 isoform gamma
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK475409.1, AF217564.1 and AABR07061848.1. Transcript Variant: This variant (3) uses an alternate 3' structure compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. It encodes isoform gamma which is longer and has a distinct C-terminus, compared to isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF217564.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACGCCA AGGTCGTCGC CGTGCTGGCC CTGGTGCTGG CCGCGCTCTG CATCAGTGAC 
GGTAAGCCAG TCAGCCTGAG CTACAGATGC CCCTGCCGAT TCTTTGAGAG CCATGTCGCC 
AGAGCCAACG TCAAACATCT GAAAATCCTC AACACTCCAA ACTGTGCCCT TCAGATTGTT 
GCAAGGCTGA AAAGCAACAA CAGACAAGTG TGCATTGACC CGAAATTAAA GTGGATCCAA 
GAGTACCTGG ACAAAGCCTT AAACAAGGGG CGCAGAGAAG AAAAAGTGGG GAAAAAAGAA 
AAGATAGGAA AAAAGAAGCG ACAGAAGAAG AGAAAGGCGG CCCAGAAAAA GAAAAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029055.1
CDS	82..441
Translation	MDAKVVAVLALVLAALCISDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKSNNRQVCIDPKLKWIQEYLDKALNKGRREEKVGKKEKIGKKKRQKKRKAAQKKKN

Target ORF information:

RefSeq Version	NM_001033883.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033883.1

ORF Insert Sequence:

ATGGACGCCA AGGTCGTCGC CGTGCTGGCC CTGGTGCTGG CCGCGCTCTG CATCAGTGAC 
GGTAAGCCAG TCAGCCTGAG CTACAGATGC CCCTGCCGAT TCTTTGAGAG CCATGTCGCC 
AGAGCCAACG TCAAACATCT GAAAATCCTC AACACTCCAA ACTGTGCCCT TCAGATTGTT 
GCAAGGCTGA AAAGCAACAA CAGACAAGTG TGCATTGACC CGAAATTAAA GTGGATCCAA 
GAGTACCTGG ACAAAGCCTT AAACAAGGGG CGCAGAGAAG AAAAAGTGGG GAAAAAAGAA 
AAGATAGGAA AAAAGAAGCG ACAGAAGAAG AGAAAGGCGG CCCAGAAAAA GAAAAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Annexin 1 inhibits remifentanil-induced hyperalgesia and NMDA receptor phosphorylation via regulating spinal CXCL12/CXCR4 in rats.
Neuroscience research14448-55(2019 Jul)
Li T,Wang H,Wang J,Chen Y,Yang C,Zhao M,Wang G,Yang Z

CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway.
International journal of biological macromolecules124460-468(2019 Mar)
Gao D,Tang T,Zhu J,Tang Y,Sun H,Li S

Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway.
BMC complementary and alternative medicine18(1)330(2018 Dec)
Huang X,Mao W,Zhang T,Wang M,Wang X,Li Y,Zhang L,Yao D,Cai X,Wang L

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways.
Molecular medicine reports18(5)4374-4380(2018 Nov)
Tian Y,Yin H,Deng X,Tang B,Ren X,Jiang T

Epigenetic upregulation of CXCL12 expression contributes to the acquisition and maintenance of morphine-induced conditioned place preference.
Experimental neurology30655-63(2018 08)
Liu H,Wei J,Liu M,Wu S,Ma C,Liu C,Huang K,Zhang X,Guo R,Zhang K,Xin W