| Gene Symbol | Il25 |
| Entrez Gene ID | 140806 |
| Full Name | interleukin 25 |
| Synonyms | IL-17e,Il17e |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Il25 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Il25 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il25 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu15586 Clone ID Related Accession (Same CDS sequence) NM_080729.3 Accession Version NM_080729.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 510bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575648000000 Organism Mus musculus(house mouse) Product interleukin-25 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ554452.1, AF458060.1, BX517868.1 and AI429629.1. On Jun 19, 2010 this sequence version replaced NM_080729.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC120568.1, AF458060.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
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361
421
481ATGTACCAGG CTGTTGCATT CTTGGCAATG ATCGTGGGAA CCCACACCGT CAGCTTGCGG
ATCCAGGAGG GCTGCAGTCA CTTGCCCAGC TGCTGCCCCA GCAAAGAGCA AGAACCCCCG
GAGGAGTGGC TGAAGTGGAG CTCTGCATCT GTGTCCCCCC CAGAGCCTCT GAGCCACACC
CACCACGCAG AATCCTGCAG GGCCAGCAAG GATGGCCCCC TCAACAGCAG GGCCATCTCT
CCTTGGAGCT ATGAGTTGGA CAGGGACTTG AATCGGGTCC CCCAGGACCT GTACCACGCT
CGATGCCTGT GCCCACACTG CGTCAGCCTA CAGACAGGCT CCCACATGGA CCCGCTGGGC
AACTCCGTCC CACTTTACCA CAACCAGACG GTCTTCTACC GGCGGCCATG CCATGGCGAG
GAAGGTACCC ATCGCCGCTA CTGCTTGGAG CGCAGGCTCT ACCGAGTCTC CTTGGCTTGT
GTGTGTGTGC GGCCCCGGGT CATGGCTTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_542767.1 CDS 77..586 Translation 
Target ORF information:
RefSeq Version NM_080729.3 Organism Mus musculus(house mouse) Definition Mus musculus interleukin 25 (Il25), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_080729.3
ORF Insert Sequence:
1
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181
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481ATGTACCAGG CTGTTGCATT CTTGGCAATG ATCGTGGGAA CCCACACCGT CAGCTTGCGG
ATCCAGGAGG GCTGCAGTCA CTTGCCCAGC TGCTGCCCCA GCAAAGAGCA AGAACCCCCG
GAGGAGTGGC TGAAGTGGAG CTCTGCATCT GTGTCCCCCC CAGAGCCTCT GAGCCACACC
CACCACGCAG AATCCTGCAG GGCCAGCAAG GATGGCCCCC TCAACAGCAG GGCCATCTCT
CCTTGGAGCT ATGAGTTGGA CAGGGACTTG AATCGGGTCC CCCAGGACCT GTACCACGCT
CGATGCCTGT GCCCACACTG CGTCAGCCTA CAGACAGGCT CCCACATGGA CCCGCTGGGC
AACTCCGTCC CACTTTACCA CAACCAGACG GTCTTCTACC GGCGGCCATG CCATGGCGAG
GAAGGTACCC ATCGCCGCTA CTGCTTGGAG CGCAGGCTCT ACCGAGTCTC CTTGGCTTGT
GTGTGTGTGC GGCCCCGGGT CATGGCTTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu49659 Clone ID Related Accession (Same CDS sequence) XM_017315843.1 Accession Version XM_017315843.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 483bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1466438400000 Organism Mus musculus(house mouse) Product interleukin-25 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
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481ATGATCGTGG GAACCCACAC CGTCAGCTTG CGGATCCAGG AGGGCTGCAG TCACTTGCCC
AGCTGCTGCC CCAGCAAAGA GCAAGAACCC CCGGAGGAGT GGCTGAAGTG GAGCTCTGCA
TCTGTGTCCC CCCCAGAGCC TCTGAGCCAC ACCCACCACG CAGAATCCTG CAGGGCCAGC
AAGGATGGCC CCCTCAACAG CAGGGCCATC TCTCCTTGGA GCTATGAGTT GGACAGGGAC
TTGAATCGGG TCCCCCAGGA CCTGTACCAC GCTCGATGCC TGTGCCCACA CTGCGTCAGC
CTACAGACAG GCTCCCACAT GGACCCGCTG GGCAACTCCG TCCCACTTTA CCACAACCAG
ACGGTCTTCT ACCGGCGGCC ATGCCATGGC GAGGAAGGTA CCCATCGCCG CTACTGCTTG
GAGCGCAGGC TCTACCGAGT CTCCTTGGCT TGTGTGTGTG TGCGGCCCCG GGTCATGGCT
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_017171332.1 CDS 182..664 Translation
Target ORF information:
RefSeq Version XM_017315843.1 Organism Mus musculus(house mouse) Definition Mus musculus interleukin 25 (Il25), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_017315843.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGATCGTGG GAACCCACAC CGTCAGCTTG CGGATCCAGG AGGGCTGCAG TCACTTGCCC
AGCTGCTGCC CCAGCAAAGA GCAAGAACCC CCGGAGGAGT GGCTGAAGTG GAGCTCTGCA
TCTGTGTCCC CCCCAGAGCC TCTGAGCCAC ACCCACCACG CAGAATCCTG CAGGGCCAGC
AAGGATGGCC CCCTCAACAG CAGGGCCATC TCTCCTTGGA GCTATGAGTT GGACAGGGAC
TTGAATCGGG TCCCCCAGGA CCTGTACCAC GCTCGATGCC TGTGCCCACA CTGCGTCAGC
CTACAGACAG GCTCCCACAT GGACCCGCTG GGCAACTCCG TCCCACTTTA CCACAACCAG
ACGGTCTTCT ACCGGCGGCC ATGCCATGGC GAGGAAGGTA CCCATCGCCG CTACTGCTTG
GAGCGCAGGC TCTACCGAGT CTCCTTGGCT TGTGTGTGTG TGCGGCCCCG GGTCATGGCT
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation.
Scientific reports8(1)18052(2018 12)
Hiraishi Y,Yamaguchi S,Yoshizaki T,Nambu A,Shimura E,Takamori A,Narushima S,Nakanishi W,Asada Y,Numata T,Suzukawa M,Yamauchi Y,Matsuda A,Arae K,Morita H,Hoshino T,Suto H,Okumura K,Matsumoto K,Saito H,Sudo K,Iikura M,Nagase T,Nakae S
The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation.
Science immunology3(28)(2018 10)
Bankova LG,Dwyer DF,Yoshimoto E,Ualiyeva S,McGinty JW,Raff H,von Moltke J,Kanaoka Y,Frank Austen K,Barrett NA
Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
Immunity49(1)33-41.e7(2018 07)
Nadjsombati MS,McGinty JW,Lyons-Cohen MR,Jaffe JB,DiPeso L,Schneider C,Miller CN,Pollack JL,Nagana Gowda GA,Fontana MF,Erle DJ,Anderson MS,Locksley RM,Raftery D,von Moltke J
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
Nature559(7715)627-631(2018 07)
Miller CN,Proekt I,von Moltke J,Wells KL,Rajpurkar AR,Wang H,Rattay K,Khan IS,Metzger TC,Pollack JL,Fries AC,Lwin WW,Wigton EJ,Parent AV,Kyewski B,Erle DJ,Hogquist KA,Steinmetz LM,Locksley RM,Anderson MS
Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells.
Nature559(7715)622-626(2018 07)
Bornstein C,Nevo S,Giladi A,Kadouri N,Pouzolles M,Gerbe F,David E,Machado A,Chuprin A,Tóth B,Goldberg O,Itzkovitz S,Taylor N,Jay P,Zimmermann VS,Abramson J,Amit I
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