Signaling by Interleukins
Homo sapiens (human) Signaling by Interleukins (provided by Reactome)
About the Signaling by Interleukins pathway
Interleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but are now known to be produced by many other cells throughout the body. They have pleiotropic effects on cells which bind them, impacting processes such as tissue growth and repair, hematopoietic homeostasis, and multiple levels of the host defense against pathogens where they are an essential part of the immune system.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
312 gene
| Gene Symbol | Full Name |
|---|---|
| ACTN2 | actinin, alpha 2 |
| ANGPT1 | angiopoietin 1 |
| ARAF | A-Raf proto-oncogene, serine/threonine kinase |
| ARRB1 | arrestin, beta 1 |
| ARRB2 | arrestin, beta 2 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase |
| BTC | betacellulin |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) |
| CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase |
| CHUK | conserved helix-loop-helix ubiquitous kinase |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) |
| CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
| CSK | c-src tyrosine kinase |
| DLG4 | discs, large homolog 4 (Drosophila) |
| HBEGF | heparin-binding EGF-like growth factor |
| DUSP1 | dual specificity phosphatase 1 |
| DUSP2 | dual specificity phosphatase 2 |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| DUSP6 | dual specificity phosphatase 6 |
| DUSP7 | dual specificity phosphatase 7 |
| DUSP8 | dual specificity phosphatase 8 |
| DUSP9 | dual specificity phosphatase 9 |
| EGF | epidermal growth factor |
| EGFR | epidermal growth factor receptor |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 |
| EREG | epiregulin |
| PTK2B | protein tyrosine kinase 2 beta |
| FGA | fibrinogen alpha chain |
| FGB | fibrinogen beta chain |
| FGF1 | fibroblast growth factor 1 (acidic) |
| FGF2 | fibroblast growth factor 2 (basic) |
| FGF3 | fibroblast growth factor 3 |
| FGF4 | fibroblast growth factor 4 |
| FGF5 | fibroblast growth factor 5 |
| FGF6 | fibroblast growth factor 6 |
| FGF7 | fibroblast growth factor 7 |
| FGF8 | fibroblast growth factor 8 (androgen-induced) |
| FGF9 | fibroblast growth factor 9 |
| FGF10 | fibroblast growth factor 10 |
| FGFR1 | fibroblast growth factor receptor 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FGFR2 | fibroblast growth factor receptor 2 |
| FGFR4 | fibroblast growth factor receptor 4 |
| FGG | fibrinogen gamma chain |
| FN1 | fibronectin 1 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase |
| GRB2 | growth factor receptor-bound protein 2 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 |
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| GRIN2C | glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
| GRIN2D | glutamate receptor, ionotropic, N-methyl D-aspartate 2D |
| HCK | HCK proto-oncogene, Src family tyrosine kinase |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) |
| NRG1 | neuregulin 1 |
| HRAS | Harvey rat sarcoma viral oncogene homolog |
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| IL1A | interleukin 1, alpha |
| IL1B | interleukin 1, beta |
| IL1R1 | interleukin 1 receptor, type I |
| IL1RAP | interleukin 1 receptor accessory protein |
| IL1RN | interleukin 1 receptor antagonist |
| IL2 | interleukin 2 |
| IL2RA | interleukin 2 receptor, alpha |
| IL2RB | interleukin 2 receptor, beta |
| IL2RG | interleukin 2 receptor, gamma |
| IL3 | interleukin 3 |
| IL3RA | interleukin 3 receptor, alpha (low affinity) |
| IL5 | interleukin 5 |
| IL5RA | interleukin 5 receptor, alpha |
| IL6 | interleukin 6 |
| IL6R | interleukin 6 receptor |
| IL6ST | interleukin 6 signal transducer |
| IL7 | interleukin 7 |
| IL7R | interleukin 7 receptor |
| IL18 | interleukin 18 |
| INPP5D | inositol polyphosphate-5-phosphatase D |
| INPPL1 | inositol polyphosphate phosphatase-like 1 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 |
| IRS1 | insulin receptor substrate 1 |
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
| JAK1 | Janus kinase 1 |
| JAK2 | Janus kinase 2 |
