Homo sapiens (human) Downstream signaling of activated FGFR1 (provided by Reactome)
About the Downstream signaling of activated FGFR1 pathway
Signaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that become tyrosine phosphorylated in response to FGF-stimulation and form a complex with additional complement of signaling proteins. In addition to the catalytic PTK core, the cytoplasmic domain of FGFR contains several regulatory sequences. The juxtamembrane domain of FGFRs is considerably longer than that of other receptor tyrosine kinases. This region contains a highly conserved sequence that serves as a binding site for the phosphotyrosine binding (PTB) domain of FRS2. A variety of signaling proteins are phosphorylated in response to FGF stimulation, including Shc, phospholipase-C gamma and FRS2 leading to stimulation of intracellular signaling pathways that control cell proliferation, cell differentiation, cell migration, cell survival and cell shape.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
311 gene
| Gene Symbol | Full Name |
|---|---|
| ACTN2 | actinin, alpha 2 |
| ADCY1 | adenylate cyclase 1 (brain) |
| ADCY2 | adenylate cyclase 2 (brain) |
| ADCY3 | adenylate cyclase 3 |
| ADCY5 | adenylate cyclase 5 |
| ADCY6 | adenylate cyclase 6 |
| ADCY7 | adenylate cyclase 7 |
| ADCY8 | adenylate cyclase 8 (brain) |
| ADCY9 | adenylate cyclase 9 |
| ADRBK1 | adrenergic, beta, receptor kinase 1 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 |
| ANGPT1 | angiopoietin 1 |
| ARAF | A-Raf proto-oncogene, serine/threonine kinase |
| ARRB1 | arrestin, beta 1 |
| ARRB2 | arrestin, beta 2 |
| BAD | BCL2-associated agonist of cell death |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase |
| BTC | betacellulin |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) |
| CAMK4 | calcium/calmodulin-dependent protein kinase IV |
| CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase |
| CD19 | CD19 molecule |
| CD28 | CD28 molecule |
| CD80 | CD80 molecule |
| CD86 | CD86 molecule |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| CHUK | conserved helix-loop-helix ubiquitous kinase |
| CREB1 | cAMP responsive element binding protein 1 |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) |
| CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
| CSK | c-src tyrosine kinase |
| DLG4 | discs, large homolog 4 (Drosophila) |
| HBEGF | heparin-binding EGF-like growth factor |
| DUSP1 | dual specificity phosphatase 1 |
| DUSP2 | dual specificity phosphatase 2 |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| DUSP6 | dual specificity phosphatase 6 |
| DUSP7 | dual specificity phosphatase 7 |
| DUSP8 | dual specificity phosphatase 8 |
| DUSP9 | dual specificity phosphatase 9 |
| EGF | epidermal growth factor |
| EGFR | epidermal growth factor receptor |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 |
| EREG | epiregulin |
| FGA | fibrinogen alpha chain |
| FGB | fibrinogen beta chain |
| FGF1 | fibroblast growth factor 1 (acidic) |
| FGF2 | fibroblast growth factor 2 (basic) |
| FGF3 | fibroblast growth factor 3 |
| FGF4 | fibroblast growth factor 4 |
| FGF5 | fibroblast growth factor 5 |
| FGF6 | fibroblast growth factor 6 |
| FGF7 | fibroblast growth factor 7 |
| FGF8 | fibroblast growth factor 8 (androgen-induced) |
| FGF9 | fibroblast growth factor 9 |
| FGF10 | fibroblast growth factor 10 |
| FGFR1 | fibroblast growth factor receptor 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FGFR2 | fibroblast growth factor receptor 2 |
| FGFR4 | fibroblast growth factor receptor 4 |
| FGG | fibrinogen gamma chain |
| FOXO1 | forkhead box O1 |
| FOXO3 | forkhead box O3 |
| FN1 | fibronectin 1 |
| MTOR | mechanistic target of rapamycin (serine/threonine kinase) |
| FYN | FYN proto-oncogene, Src family tyrosine kinase |
| GAB1 | GRB2-associated binding protein 1 |
| GRB2 | growth factor receptor-bound protein 2 |
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| GRIN2C | glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
| GRIN2D | glutamate receptor, ionotropic, N-methyl D-aspartate 2D |
| GSK3A | glycogen synthase kinase 3 alpha |
| GSK3B | glycogen synthase kinase 3 beta |
| NRG1 | neuregulin 1 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 |
| HRAS | Harvey rat sarcoma viral oncogene homolog |
| IL2 | interleukin 2 |
| IL2RA | interleukin 2 receptor, alpha |
| IL2RB | interleukin 2 receptor, beta |
| IL2RG | interleukin 2 receptor, gamma |
| IL3 | interleukin 3 |
| IL3RA | interleukin 3 receptor, alpha (low affinity) |
| IL5 | interleukin 5 |
| IL5RA | interleukin 5 receptor, alpha |
| IRS1 | insulin receptor substrate 1 |
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
