.gene-hot-human-pathway-tcf-dependent-signaling-in-response-to-wnt
Homo sapiens (human) TCF dependent signaling in response to WNT (provided by Reactome)
About the TCF dependent signaling in response to WNT pathway
19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of so-called 'canonical' and 'non-canonical' WNT signaling. In the canonical WNT signaling pathway, binding of a WNT ligand to the Frizzled (FZD) and lipoprotein receptor-related protein (LRP) receptors results in the inactivation of the destruction complex, the stabilization and nuclear translocation of beta-catenin and subsequent activation of T-cell factor/lymphoid enhancing factor (TCF/LEF)-dependent transcription. Transcriptional activation in response to canonical WNT signaling controls processes such as cell fate, proliferation and self renewal of stem cells, as well as contributing to oncogenesis (reviewed in MacDonald et al, 2009; Saito-Diaz et al, 2013; Kim et al, 2013).
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
231 gene
| Gene Symbol | Full Name |
|---|---|
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 |
| APC | adenomatous polyposis coli |
| XIAP | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase |
| BCL9 | B-cell CLL/lymphoma 9 |
| CAV1 | caveolin 1, caveolae protein, 22kDa |
| CREBBP | CREB binding protein |
| CSNK1A1 | casein kinase 1, alpha 1 |
| CSNK1E | casein kinase 1, epsilon |
| CSNK1G2 | casein kinase 1, gamma 2 |
| CSNK2A1 | casein kinase 2, alpha 1 polypeptide |
| CSNK2A2 | casein kinase 2, alpha prime polypeptide |
| CSNK2B | casein kinase 2, beta polypeptide |
| CTBP1 | C-terminal binding protein 1 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa |
| DVL1 | dishevelled segment polarity protein 1 |
| DVL2 | dishevelled segment polarity protein 2 |
| DVL3 | dishevelled segment polarity protein 3 |
| EP300 | E1A binding protein p300 |
| FZD2 | frizzled class receptor 2 |
| GSK3B | glycogen synthase kinase 3 beta |
| HIST1H2AE | histone cluster 1, H2ae |
| HIST1H2AD | histone cluster 1, H2ad |
| H2AFX | H2A histone family, member X |
| H2AFZ | H2A histone family, member Z |
| HIST1H2BD | histone cluster 1, H2bd |
| HIST1H2BB | histone cluster 1, H2bb |
| H3F3A | H3 histone, family 3A |
| H3F3B | H3 histone, family 3B (H3.3B) |
| HDAC1 | histone deacetylase 1 |
| LRP6 | low density lipoprotein receptor-related protein 6 |
| LRP5 | low density lipoprotein receptor-related protein 5 |
| MEN1 | multiple endocrine neoplasia I |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme |
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta |
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma |
| PPP2R5D | protein phosphatase 2, regulatory subunit B', delta |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform |
| PSMA1 | proteasome subunit alpha 1 |
| PSMA2 | proteasome subunit alpha 2 |
| PSMA3 | proteasome subunit alpha 3 |
| PSMA4 | proteasome subunit alpha 4 |
| PSMA5 | proteasome subunit alpha 5 |
| PSMA6 | proteasome subunit alpha 6 |
| PSMA7 | proteasome subunit alpha 7 |
| PSMB1 | proteasome subunit beta 1 |
| PSMB2 | proteasome subunit beta 2 |
| PSMB3 | proteasome subunit beta 3 |
| PSMB4 | proteasome subunit beta 4 |
| PSMB5 | proteasome subunit beta 5 |
| PSMB6 | proteasome subunit beta 6 |
| PSMB7 | proteasome subunit beta 7 |
| PSMB8 | proteasome subunit beta 8 |
| PSMB9 | proteasome subunit beta 9 |
| PSMB10 | proteasome subunit beta 10 |
| PSMC1 | proteasome 26S subunit, ATPase 1 |
| PSMC2 | proteasome 26S subunit, ATPase 2 |
| PSMC3 | proteasome 26S subunit, ATPase 3 |
| PSMC4 | proteasome 26S subunit, ATPase 4 |
| PSMC5 | proteasome 26S subunit, ATPase 5 |
| PSMC6 | proteasome 26S subunit, ATPase 6 |
| PSMD1 | proteasome 26S subunit, non-ATPase 1 |
| PSMD2 | proteasome 26S subunit, non-ATPase 2 |
| PSMD3 | proteasome 26S subunit, non-ATPase 3 |
| PSMD4 | proteasome 26S subunit, non-ATPase 4 |
| PSMD5 | proteasome 26S subunit, non-ATPase 5 |
| PSMD7 | proteasome 26S subunit, non-ATPase 7 |
| PSMD8 | proteasome 26S subunit, non-ATPase 8 |
| PSMD9 | proteasome 26S subunit, non-ATPase 9 |
| PSMD10 | proteasome 26S subunit, non-ATPase 10 |
| PSMD11 | proteasome 26S subunit, non-ATPase 11 |
| PSMD12 | proteasome 26S subunit, non-ATPase 12 |
| PSMD13 | proteasome 26S subunit, non-ATPase 13 |
| PSME1 | proteasome activator subunit 1 |
| PSME2 | proteasome activator subunit 2 |
| RBBP5 | retinoblastoma binding protein 5 |
| RPS27A | ribosomal protein S27a |
| RYK | receptor-like tyrosine kinase |
| SFRP1 | secreted frizzled-related protein 1 |
| SFRP2 | secreted frizzled-related protein 2 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
| SOX2 | SRY (sex determining region Y)-box 2 |
| SOX3 | SRY (sex determining region Y)-box 3 |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SOX9 | SRY (sex determining region Y)-box 9 |
| SRY | sex determining region Y |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) |
| TERT | telomerase reverse transcriptase |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) |
| TLE2 | transducin-like enhancer of split 2 |
| TLE3 | transducin-like enhancer of split 3 |
| TLE4 | transducin-like enhancer of split 4 |
| UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 |
| UBB | ubiquitin B |
