High-Throughput DNA Library Assembly Service

You can use our custom-built combinatorial DNA libraries in a variety of applications across many disciplines of life sciences, from plant biology to drug development. The following lists three major areas of combinatorial DNA library applications:

Synthetic Biology

• Metabolic Pathway and Microbial Strain Engineering: screen and optimize your synthetic molecular pathways to develop the most efficient metabolic gene circuits for chemical, drug, and biofuel production.
• Genome Engineering: screen high-throughput libraries of synthetic nuclease- or CRISPR/Cas9-based constructs for highly effective genome editing.

Protein Engineering

• Create new multi-domain proteins for structural or functional screening.
• Optimize protein function through directed evolution.
• Generate recombinant protein or chimeric antibody libraries for high-throughput screening for biologic drug discovery and development.

Gene Expression Regulation

• Determine the optimal combination of promoter, ribosome binding site, terminator, and other regulatory elements for your construct or expression system.
• Create a library of reporter-gene constructs for systematic promoter analysis.
• Express any gene of interest under the control of different promoters, e.g. for inducible or tissue-specific manipulation of lethal or developmentally vital genes.