gene-hot-human-pathway-gpcr-ligand-binding
Homo sapiens (human) GPCR ligand binding (provided by Reactome)
About the GPCR ligand binding pathway
There are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all physiological processes (Frederiksson 2003). GPCRs are receptors for a diverse range of ligands from large proteins to photons (Kristiansen et al. 2004) and have an equal diversity of ligand-binding mechanisms (Gether et al. 2002).
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
447 gene
| Gene Symbol | Full Name |
|---|---|
| ADCYAP1 | adenylate cyclase activating polypeptide 1 (pituitary) |
| ADCYAP1R1 | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
| ADM | adrenomedullin |
| ADORA1 | adenosine A1 receptor |
| ADORA2A | adenosine A2a receptor |
| ADORA2B | adenosine A2b receptor |
| ADORA3 | adenosine A3 receptor |
| ADRA1D | adrenoceptor alpha 1D |
| ADRA1B | adrenoceptor alpha 1B |
| ADRA1A | adrenoceptor alpha 1A |
| ADRA2A | adrenoceptor alpha 2A |
| ADRA2B | adrenoceptor alpha 2B |
| ADRA2C | adrenoceptor alpha 2C |
| ADRB1 | adrenoceptor beta 1 |
| ADRB2 | adrenoceptor beta 2, surface |
| ADRB3 | adrenoceptor beta 3 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| AGTR1 | angiotensin II receptor, type 1 |
| AGTR2 | angiotensin II receptor, type 2 |
| APLNR | apelin receptor |
| ANXA1 | annexin A1 |
| APP | amyloid beta (A4) precursor protein |
| AVP | arginine vasopressin |
| AVPR1A | arginine vasopressin receptor 1A |
| AVPR1B | arginine vasopressin receptor 1B |
| AVPR2 | arginine vasopressin receptor 2 |
| OPN1SW | opsin 1 (cone pigments), short-wave-sensitive |
| BDKRB1 | bradykinin receptor B1 |
| BDKRB2 | bradykinin receptor B2 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 |
| BRS3 | bombesin-like receptor 3 |
| C3 | complement component 3 |
| C3AR1 | complement component 3a receptor 1 |
| C5 | complement component 5 |
| C5AR1 | complement component 5a receptor 1 |
| CALCA | calcitonin-related polypeptide alpha |
| CALCB | calcitonin-related polypeptide beta |
| CALCR | calcitonin receptor |
| CASR | calcium-sensing receptor |
| CCK | cholecystokinin |
| CCKAR | cholecystokinin A receptor |
| CCKBR | cholecystokinin B receptor |
| ADGRE5 | adhesion G protein-coupled receptor E5 |
| CGA | glycoprotein hormones, alpha polypeptide |
| CHRM1 | cholinergic receptor, muscarinic 1 |
| CHRM2 | cholinergic receptor, muscarinic 2 |
| CHRM3 | cholinergic receptor, muscarinic 3 |
| CHRM4 | cholinergic receptor, muscarinic 4 |
| CHRM5 | cholinergic receptor, muscarinic 5 |
| CCR1 | chemokine (C-C motif) receptor 1 |
| CCR3 | chemokine (C-C motif) receptor 3 |
| CCR4 | chemokine (C-C motif) receptor 4 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) |
| CCR6 | chemokine (C-C motif) receptor 6 |
| CCR7 | chemokine (C-C motif) receptor 7 |
| CCR8 | chemokine (C-C motif) receptor 8 |
| ACKR2 | atypical chemokine receptor 2 |
| LTB4R | leukotriene B4 receptor |
| CNR1 | cannabinoid receptor 1 (brain) |
| CNR2 | cannabinoid receptor 2 (macrophage) |
| CRH | corticotropin releasing hormone |
| CRHR1 | corticotropin releasing hormone receptor 1 |
| CRHR2 | corticotropin releasing hormone receptor 2 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| DRD1 | dopamine receptor D1 |
| DRD2 | dopamine receptor D2 |
| DRD3 | dopamine receptor D3 |
| DRD4 | dopamine receptor D4 |
| DRD5 | dopamine receptor D5 |
| S1PR1 | sphingosine-1-phosphate receptor 1 |
| LPAR1 | lysophosphatidic acid receptor 1 |
| S1PR3 | sphingosine-1-phosphate receptor 3 |
| EDN1 | endothelin 1 |
| EDN2 | endothelin 2 |
| EDN3 | endothelin 3 |
| EDNRA | endothelin receptor type A |
| EDNRB | endothelin receptor type B |
| ADGRE1 | adhesion G protein-coupled receptor E1 |
| F2 | coagulation factor II (thrombin) |
| F2R | coagulation factor II (thrombin) receptor |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
| F2RL2 | coagulation factor II (thrombin) receptor-like 2 |
| FPR1 | formyl peptide receptor 1 |
| FPR2 | formyl peptide receptor 2 |
| FPR3 | formyl peptide receptor 3 |
| FSHB | follicle stimulating hormone, beta polypeptide |
| FSHR | follicle stimulating hormone receptor |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) |
| FZD2 | frizzled class receptor 2 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 |
| GALR1 | galanin receptor 1 |
| GCG | glucagon |
| GCGR | glucagon receptor |
| OPN1MW | opsin 1 (cone pigments), medium-wave-sensitive |
| GHRH | growth hormone releasing hormone |
| GHRHR | growth hormone releasing hormone receptor |
| GHSR | growth hormone secretagogue receptor |
| GIP | gastric inhibitory polypeptide |
| GIPR | gastric inhibitory polypeptide receptor |
