SLC-mediated transmembrane transport
Homo sapiens (human) SLC-mediated transmembrane transport (provided by Reactome)
About the SLC-mediated transmembrane transport pathway
Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates (ions or water) down their electrochemical gradient, at an extremely high efficiency (up to 108 s-1). Transporters facilitate the movement of a specific substrate either against or following their concentration gradient, at a lower speed (about 102 -104 s-1); as generally believed, conformational change of the transporter protein is involved in the transfer process.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
263 gene
| Gene Symbol | Full Name |
|---|---|
| ALB | albumin |
| APOD | apolipoprotein D |
| AVP | arginine vasopressin |
| RUNX1 | runt-related transcription factor 1 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 |
| CP | ceruloplasmin (ferroxidase) |
| SLC25A10 | solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 |
| CTNS | cystinosin, lysosomal cystine transporter |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 |
| G6PC | glucose-6-phosphatase, catalytic subunit |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 |
| GCK | glucokinase (hexokinase 4) |
| GCKR | glucokinase (hexokinase 4) regulator |
| HK1 | hexokinase 1 |
| HK2 | hexokinase 2 |
| HK3 | hexokinase 3 (white cell) |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 |
| LCN1 | lipocalin 1 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 |
| NUP88 | nucleoporin 88kDa |
| NUP98 | nucleoporin 98kDa |
| SLC22A18 | solute carrier family 22, member 18 |
| RANBP2 | RAN binding protein 2 |
| RHAG | Rh-associated glycoprotein |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
| SLC4A3 | solute carrier family 4 (anion exchanger), member 3 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 |
| SLC1A6 | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
| SLC1A7 | solute carrier family 1 (glutamate transporter), member 7 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 |
| SLC2A2 | solute carrier family 2 (facilitated glucose transporter), member 2 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 |
| SLC2A4 | solute carrier family 2 (facilitated glucose transporter), member 4 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 |
| SLC5A1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
| SLC5A2 | solute carrier family 5 (sodium/glucose cotransporter), member 2 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 |
| SLC5A4 | solute carrier family 5 (glucose activated ion channel), member 4 |
| SLC5A5 | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
| SLC6A1 | solute carrier family 6 (neurotransmitter transporter), member 1 |
| SLC6A2 | solute carrier family 6 (neurotransmitter transporter), member 2 |
| SLC6A3 | solute carrier family 6 (neurotransmitter transporter), member 3 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 |
| SLC6A7 | solute carrier family 6 (neurotransmitter transporter), member 7 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 |
| SLC6A11 | solute carrier family 6 (neurotransmitter transporter), member 11 |
| SLC6A12 | solute carrier family 6 (neurotransmitter transporter), member 12 |
| SLC6A13 | solute carrier family 6 (neurotransmitter transporter), member 13 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
| SLC8A2 | solute carrier family 8 (sodium/calcium exchanger), member 2 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 |
| SLC8A3 | solute carrier family 8 (sodium/calcium exchanger), member 3 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 |
| SLC9A2 | solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 |
| SLC9A3 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 |
| SLC9A5 | solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 |
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 |
| SLC12A1 | solute carrier family 12 (sodium/potassium/chloride transporter), member 1 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
| SLC12A3 | solute carrier family 12 (sodium/chloride transporter), member 3 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 |
| SLC13A1 | solute carrier family 13 (sodium/sulfate symporter), member 1 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) |
| SLC15A1 | solute carrier family 15 (oligopeptide transporter), member 1 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
| SLC17A1 | solute carrier family 17 (organic anion transporter), member 1 |
| SLC34A1 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 |
| SLC18A2 | solute carrier family 18 (vesicular monoamine transporter), member 2 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 |
| SLCO2A1 | solute carrier organic anion transporter family, member 2A1 |
| SLCO1A2 | solute carrier organic anion transporter family, member 1A2 |
| SLC22A1 | solute carrier family 22 (organic cation transporter), member 1 |
| SLC22A3 | solute carrier family 22 (organic cation transporter), member 3 |
| SLC22A2 | solute carrier family 22 (organic cation transporter), member 2 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 |
| SLC22A5 | solute carrier family 22 (organic cation/carnitine transporter), member 5 |
| TPR | translocated promoter region, nuclear basket protein |
| SLC35A2 | solute carrier family 35 (UDP-galactose transporter), member A2 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 |
| SLC30A2 | solute carrier family 30 (zinc transporter), member 2 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 |
| NUP214 | nucleoporin 214kDa |
| AAAS | achalasia, adrenocortical insufficiency, alacrimia |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 |
| SLC14A2 | solute carrier family 14 (urea transporter), member 2 |
| RAE1 | ribonucleic acid export 1 |
