gene-hot-human-pathway-signaling-by-gpcr_2022
Homo sapiens (human) Signaling by GPCR (provided by Reactome)
About the Signaling by GPCR pathway
G protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors in humans, accounting for more than 1% of the protein-coding capacity of the human genome.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
1277 gene
| Gene Symbol | Full Name |
|---|---|
| ABR | active BCR-related |
| ACTN2 | actinin, alpha 2 |
| ADCY1 | adenylate cyclase 1 (brain) |
| ADCY2 | adenylate cyclase 2 (brain) |
| ADCY3 | adenylate cyclase 3 |
| ADCY5 | adenylate cyclase 5 |
| ADCY6 | adenylate cyclase 6 |
| ADCY7 | adenylate cyclase 7 |
| ADCY8 | adenylate cyclase 8 (brain) |
| ADCY9 | adenylate cyclase 9 |
| ADCYAP1 | adenylate cyclase activating polypeptide 1 (pituitary) |
| ADCYAP1R1 | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
| ADM | adrenomedullin |
| ADORA1 | adenosine A1 receptor |
| ADORA2A | adenosine A2a receptor |
| ADORA2B | adenosine A2b receptor |
| ADORA3 | adenosine A3 receptor |
| ADRA1D | adrenoceptor alpha 1D |
| ADRA1B | adrenoceptor alpha 1B |
| ADRA1A | adrenoceptor alpha 1A |
| ADRA2A | adrenoceptor alpha 2A |
| ADRA2B | adrenoceptor alpha 2B |
| ADRA2C | adrenoceptor alpha 2C |
| ADRB1 | adrenoceptor beta 1 |
| ADRB2 | adrenoceptor beta 2, surface |
| ADRB3 | adrenoceptor beta 3 |
| ADRBK1 | adrenergic, beta, receptor kinase 1 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| AGTR1 | angiotensin II receptor, type 1 |
| AGTR2 | angiotensin II receptor, type 2 |
| APLNR | apelin receptor |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 |
| ANGPT1 | angiopoietin 1 |
| ANXA1 | annexin A1 |
| APP | amyloid beta (A4) precursor protein |
| ARAF | A-Raf proto-oncogene, serine/threonine kinase |
| RHOA | ras homolog family member A |
| RHOB | ras homolog family member B |
| RHOC | ras homolog family member C |
| RHOG | ras homolog family member G |
| ARHGAP4 | Rho GTPase activating protein 4 |
| ARRB1 | arrestin, beta 1 |
| ARRB2 | arrestin, beta 2 |
| AVP | arginine vasopressin |
| AVPR1A | arginine vasopressin receptor 1A |
| AVPR1B | arginine vasopressin receptor 1B |
| AVPR2 | arginine vasopressin receptor 2 |
| OPN1SW | opsin 1 (cone pigments), short-wave-sensitive |
| BDKRB1 | bradykinin receptor B1 |
| BDKRB2 | bradykinin receptor B2 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase |
| BRS3 | bombesin-like receptor 3 |
| BTC | betacellulin |
| C3 | complement component 3 |
| C3AR1 | complement component 3a receptor 1 |
| C5 | complement component 5 |
| C5AR1 | complement component 5a receptor 1 |
| DAGLA | diacylglycerol lipase, alpha |
| CALCA | calcitonin-related polypeptide alpha |
| CALCB | calcitonin-related polypeptide beta |
| CALCR | calcitonin receptor |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) |
| CAMK4 | calcium/calmodulin-dependent protein kinase IV |
| CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma |
| CASR | calcium-sensing receptor |
| CCK | cholecystokinin |
| CCKAR | cholecystokinin A receptor |
| CCKBR | cholecystokinin B receptor |
| ADGRE5 | adhesion G protein-coupled receptor E5 |
| CDC42 | cell division cycle 42 |
| CDK5 | cyclin-dependent kinase 5 |
| CGA | glycoprotein hormones, alpha polypeptide |
| CHRM1 | cholinergic receptor, muscarinic 1 |
| CHRM2 | cholinergic receptor, muscarinic 2 |
| CHRM3 | cholinergic receptor, muscarinic 3 |
| CHRM4 | cholinergic receptor, muscarinic 4 |
| CHRM5 | cholinergic receptor, muscarinic 5 |
| CCR1 | chemokine (C-C motif) receptor 1 |
| CCR3 | chemokine (C-C motif) receptor 3 |
| CCR4 | chemokine (C-C motif) receptor 4 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) |
| CCR6 | chemokine (C-C motif) receptor 6 |
| CCR7 | chemokine (C-C motif) receptor 7 |
| CCR8 | chemokine (C-C motif) receptor 8 |
| ACKR2 | atypical chemokine receptor 2 |
| LTB4R | leukotriene B4 receptor |
| CNR1 | cannabinoid receptor 1 (brain) |
| CNR2 | cannabinoid receptor 2 (macrophage) |
| CREB1 | cAMP responsive element binding protein 1 |
| CRH | corticotropin releasing hormone |
| CRHR1 | corticotropin releasing hormone receptor 1 |
| CRHR2 | corticotropin releasing hormone receptor 2 |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) |
