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SPARC (Secreted protein acidic and cysteine rich) gene, Homo sapiens

Do you need expression-ready SPARC gene to study the functions and characteristics? GenScript offers SPARC gene in any custom vector for your molecular biology studies by ordering SPARC ORF clone.

About the SPARC gene

SPARC encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]

Genomic context of SPARC gene

The human SPARC gene is shown in the context of the human genome below. To see information about the SPARC gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse SPARC, rat SPARC, and human SPARC, as well as on-demand SPARC ORF clones in other 183 species.

Chromosome 5 - NC_000005.10

Genomic sequence of SPARC gene

Learn more about SPARC gene

Bibliography

1.Clinical significance of SPARC in esophageal squamous cell carcinoma.
Chen Y, et al. Biochem Biophys Res Commun, 2017 Oct 14. PMID 28818666

2.The relationship between SPARC expression in primary tumor and metastatic lymph node of resected pancreatic cancer patients and patients' survival.
Yu XZ, et al. Hepatobiliary Pancreat Dis Int, 2017 Feb. PMID 28119265

3.In phyllodes tumors of the breast expression of SPARC (osteonectin/BM40) mRNA by in situ hybridization correlates with protein expression by immunohistochemistry and is associated with tumor progression.
Kim NI, et al. Virchows Arch, 2017 Jan. PMID 27909812

4.The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease.
Wong SL, et al. Br J Pharmacol, 2017 Jan. PMID 27759879,