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PDF (Peptide deformylase, mitochondrial) gene, Homo sapiens

Do you need expression-ready PDF gene to study the functions and characteristics? GenScript offers PDF gene in any custom vector for your molecular biology studies by ordering PDF ORF clone.

About the PDF gene

Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells. [provided by RefSeq, Nov 2008]

Genomic context of PDF gene

The human PDF gene is shown in the context of the human genome below. To see information about the PDF gene in other species, please use the Search tool to select your desired species. GenScript has on-demand PDF ORF clones in other 183 species.

Chromosome 16 - NC_000016.10

Genomic sequence of PDF gene

Learn more about PDF gene

Bibliography

1.Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer.
Gao J, et al. Molecules, 2016 Mar 23. PMID 27023495

2.Overexpression of peptide deformylase in breast, colon, and lung cancers.
Randhawa H, et al. BMC Cancer, 2013 Jul 1. PMID 23815882,

3.Transcriptional regulation of the human mitochondrial peptide deformylase (PDF).
Pereira-Castro I, et al. Biochem Biophys Res Commun, 2012 May 18. PMID 22554513

4.Structure and activity of human mitochondrial peptide deformylase, a novel cancer target.
scobar-Alvarez S, et al. J Mol Biol, 2009 Apr 17. PMID 19236878,