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GenScript’s custom peptides for T cell activation assays provide synthesis of even the most difficult peptides to get all of your vaccine and immunotherapy R&D work done in a timely manor.

What is T Cell Activation?

There are two main types of T cells, helper T cells (CD4⁺) and killer T cells T cells (CD8⁺). Helper T cells are activated in response to interaction between its T Cell Receptor (TCR) and a pathogenic epitope presented on an Antigen Presenting Cells (APC) Major Histone Compatibility Complex II (MHCI). This activated helper T cell will then induce B cell mediated immunity against the pathogen. When killer T cells become active through direct interaction with pathogenic antigen on MHCI, they release cytokines, cytotoxins, and perforins to kill the pathogen directly.

How are Peptides Utilized in T Cell Activation Assays?

T Cell Activation assays utilize a small region of an infectious agent, such as a virus or tumor, in the form of a peptide, to stimulate patient derived immune cells and measure the resulting immune response to indicate possible use in a therapeutic platform. T cell activation assays include but are not limited to cytokine analysis (Elispot and AIM), flow cytometry, and cytotoxicity.

What Does GenScript’s Service Provide?

Proprietary bioinformatics tools for peptide synthesis analysis ensures production of 98% of peptides

High end synthetic methodologies to produce even the most difficult peptides in a timely manor

Quality control guarantees to minimize off target effects and enhance immunogenicity in any T cell activation assay

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  Custom Peptide Synthesis

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  Standard Peptide Library

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  Neoantigen Peptide Service

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  Micro-Scale Peptide Library

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  Large-Scale Peptide Synthesis

Interested In Learning More? Check Out Our T Cell Activation Content!