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APOE (Apolipoprotein E) gene, Homo sapiens

Do you need expression-ready APOE gene to study the functions and characteristics? GenScript offers APOE gene in any custom vector for your molecular biology studies by ordering an APOE ORF clone.

About the APOE gene

APOE gene encodes a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

Genomic context of APOE gene

The human APOE gene is shown in the context of the human genome below. To see information about the APOE gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for human APOE and mouse APOE, as well as on-demand APOE ORF clones in 183 other species.

Chromosome 19 - NC_000019.10

Genomic sequence of APOE gene

Learn more about APOE gene

Bibliography

1.Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron.
Kim H, et al. Brain, 2017 Aug 1. PMID 28899010

2.Indispensable role of lipoprotein bound-ApoE in adipogenesis and endocytosis induced by postprandial TRL.
Zhang M, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28893538

3.APOE genotype and early β-amyloid accumulation in older adults without dementia.
Lim YY, et al. Neurology, 2017 Sep 5. PMID 28794245

4.Apolipoprotein E Promotes Invasion in Oral Squamous Cell Carcinoma.
Jayakar SK, et al. Am J Pathol, 2017 Oct. PMID 28751006

5.Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans.
Larifla L, et al. PLoS One, 2017. PMID 28727855, Free PMC Article