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BAD (BCL2 associated agonist of cell death) gene, Homo sapiens

Do you need expression-ready BAD gene to study the functions and characteristics? GenScript offers BAD gene in any custom vector for your molecular biology studies by ordering an BAD ORF clone.

About the BAD gene

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

Genomic context of BAD gene

The human BAD gene is shown in the context of the human genome below. To see information about the BAD gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse BAD, rat BAD, and human BAD, as well as on-demand BAD ORF clones in other 183 species.

Chromosome 11 - NC_000011.10

Genomic sequence of BAD gene

Learn more about BAD gene

Bibliography

1.Bcl-xL deamidation and cancer: Charting the fame trajectories of legitimate child and hidden siblings.
Beaumatin F, et al. Biochim Biophys Acta, 2017 Oct. PMID 28645514

2.The long unstructured region of Bcl-xl modulates its structural dynamics.
Priya P, et al. Proteins, 2017 Aug. PMID 28486788

3.Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance.
Pécot J, et al. Cell Rep, 2016 Dec 20. PMID 28009301

4.An analysis of the sequence of the BAD gene among patients with maturity-onset diabetes of the young (MODY).
Antosik K, et al. J Pediatr Endocrinol Metab, 2017 Jan 1. PMID 27935851

5.Biphasic regulation of InsP3 receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability.
Yang J, et al. Proc Natl Acad Sci U S A, 2016 Mar 29. PMID 26976600,