Ctbp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctbp2
Entrez Gene ID	81717
Full Name	C-terminal binding protein 2
General protein information	Preferred Names C-terminal binding protein 2 Names C-terminal-binding protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q41
Summary	gene produces two transcripts; one protein is a transcriptional repressor, while the other isoform is a major component of synaptic ribbons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053335.1	NP_445787.1	C-terminal-binding protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CTBP2	XP_508100.3
Danio rerio (zebrafish)	ctbp2a	NP_001182420.1
Homo sapiens (human)	CTBP2	NP_073713.2
Danio rerio (zebrafish)	ctbp2l	NP_001015064.1
Xenopus tropicalis (tropical clawed frog)	ctbp2	NP_001008196.1
Canis lupus familiaris (dog)	LOC100684514	XP_005637947.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003893	XP_003436652.1
Mus musculus (house mouse)	Ctbp2	NP_001164215.1
Gallus gallus (chicken)	CTBP2	XP_004942401.1
Macaca mulatta (Rhesus monkey)	CTBP2	XP_001084570.2
Bos taurus (cattle)	CTBP2	NP_783643.1
Rattus norvegicus (Norway rat)	Ctbp2	NP_445787.1
Drosophila melanogaster (fruit fly)	CtBP	NP_001262524.1

Gene Ontology
Bibliography

Related articles in PubMed

How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release.
Maxeiner S, Luo F, Tan A, Schmitz F, Südhof TC
The EMBO journal35(10)1098-114(2016 05)

Oxygen-dependent acetylation and dimerization of the corepressor CtBP2 in neural stem cells.
Karaca E, Lewicki J, Hermanson O
Experimental cell research332(1)128-35(2015 Mar)

The role of C-terminal binding protein 2 in Schwann cell differentiation after sciatic nerve crush.
Cao X, Zhao P, Tao G, Zhu Y, Zhou F, Cui Z, Bao G, Xu D, Zhang G, Chen X
Journal of molecular neuroscience : MN49(3)531-8(2013 Mar)

Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration.
Wang Y, Liu F, Mao F, Hang Q, Huang X, He S, Wang Y, Cheng C, Wang H, Xu G, Zhang T, Shen A
The Journal of biological chemistry288(13)9028-34(2013 Mar)

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM
Genes & development22(10)1397-409(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ctbp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctbp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09305	NM_053335.1 Latest version!	Rattus norvegicus C-terminal binding protein 2 (Ctbp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctbp2 ( NM_053335.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445787.1 Rattus norvegicus C-terminal binding protein 2 (Ctbp2), mRNA.

Price & Availability↑

CloneID	ORa09305
Clone ID Related Accession (Same CDS sequence)	NM_053335.1
Accession Version	NM_053335.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2967bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	C-terminal-binding protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF222712.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF222712.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCGGTTC CCAGCAGGCA CATCAACATT GGCCGTTCTC AGAGCTGGGA TGCCGCTGGC 
TGGTATGAGG GCCCTTGGGA GAATGCTGGC CCTCCAGGGA GGAGAAGTTC TCTGACTTAT 
GGCCCTGGAG AAGGGGTCTG GTGTGAGCTG GTAAACCACC GTGCCCAGGA CACTGAGTCC 
TGCCTGTCCC GGGAAGCTTT TTATAACTCA CTGGCATCAA GAAAGGGCTC CGTGCCTGAC 
TTCACCTTCT ACGACAGCAG GCAGGCAGTG ATGTCTGGCC GTGGCTCCGT GCTGCCACAA 
GACTACTATG GCGACCCATC CAGGGGCACC AGGGTACCCA AGGAGCCTCC CTTCTATCGG 
GACCCAGGAA CCAGCCGGCC GGTGCCCAGC TACGGAGTGC TGGGCAGCAG AATACCATGG 
GAGCAGGTAC AAGGCCAGTT ACCTGCTCTG CAGGATGCTG GCCACCTGTA CCGGGAATCT 
GGGAGTAAAA CTGTCCTGCA TGGGCAGCGG ACACACTGCA GGGCTCCATC TCCTGGGAGG 
TATGGAAGGG AACAACCTGA TTCTAGATTA GGGATAGAGG TACCCACCTA TTCCCCCAAC 
TCCAGCCAGG TCTACAACGA TATCTGCGAA AGACCCGTTG ACTCTACCCA TGCCAGACAG 
GTGGCCCCAA CATGCCTGGT TGTGGACCCC AGCTCGACCG CCCCTACTGA GAACAGCACG 
GGGGTGGCCC CAGGTTCCCT GAATAGAGGC TACGGGCCTA CCCGAGAAAG CATCCATTCA 
AAGCTGGCTT ATGAGAATTA TGAAGCCGAC TTGTCAACAT TCCAAGGACC CGGGGGCAAG 
AGGACCGTCT ACCCTGAGTT TTTGGCCCTG CTGAGGGCAG AGGGTGTGGC AGAGGCTACC 
CTGGCAGCCC TGTTACAACA AGGCTTTGAC TCCCCAGCTG TCTTGGCCAC CCTAGAGGAT 
GCTGACATCA AGTCTGTTGC CCCCAACCTG GGCCAGGCCC GTGTCCTGAG CCGCCTGGTC 
AGCAGCTGCA GGACAGAGAT GCAGTTTCGG CGACAGGACC GGACAGGCCC TCCACCCCGC 
CATCGGTCCA GTAGCTTCAG CCACCGAAGT GAGCTGCTGC CCAATGACAC GGCCTCGCTG 
GGGACCACAG CACTGCAGTT TCACCCAGCT GGACCTTTGC AGACACCCTC TCCCCGAGGT 
GGAGATCTAG GTCGCCGCCC CTCCAGTGCA CCTTCCCAGC ACCTCCTGGA GACAGCAGCT 
ACTTACTCTG CCCCAGTGGT GGGGTCCCAG ACTCCCCACT TACCCTCCAA CTCTGGATAT 
AGCTCTCCTA CCCCTTGTGC CCTAACAGCA CGACTGGCCT CCTCCTACCC TTCACAAGCT 
GGGGTAGCCT TGACTGCTAA CCCAGGCCCC TCTGTCCCCC TTCACTCAAG TCCCAGAACA 
GCCTATTCCA CCTCCTACAC GGTGCCCATG GAACTGCTTA AGAGGGAACG CAGTGTGACC 
GCCTCTCCGC TGCCCAGCCC CCATGCCAGC CCCCAGCTTC TGCGGAAACC TGGAGCAGCC 
CCCGTGGAGC CGGCTGCCCT GCCACCAGTC AGGCAAAGTC TCCACACACC TCATCCGCCA 
TACCAGAAGG TGGCCCGGCG GACAGGGGCT CCCATCATCG TGTCAACCAT GCTAACACCA 
GAACCAAGTA TCCGCCCCCA GATCATGAAC GGCCCCCTGC ACCCCCGCCC CCTAGTGGCA 
CTGCTGGATG GCAGAGACTG CACTGTGGAA ATGCCCATCC TGAAGGACCT GGCCACTGTG 
GCCTTCTGTG ATGCACAGTC CACTCAGGAA ATCCATGAGA AGGTATTGAA TGAGGCTGTG 
GGCGCCATGA TGTACCACAC CATCACTCTC ACCCGGGAAG ACCTGGAGAA GTTCAAGGCC 
CTGAGAGTGA TTGTTCGAAT CGGTAGTGGC TACGACAATG TGGACATCAA GGCTGCTGGC 
GAACTCGGAA TCGCCGTGTG CAACATCCCA TCTGCTGCAG TGGAGGAGAC AGCAGATTCG 
ACAGTCTGCC ATATCCTCAA TCTGTATCGG CGGAACACAT GGCTGTACCA GGCCCTACGA 
GAAGGCACGC GGGTACAAAG CGTGGAACAG ATCCGTGAGG TCGCCTCAGG AGCTGCTCGG 
ATCCGAGGGG AAACACTGGG CCTCATTGGC TTTGGTCGCA CTGGGCAGGC AGTTGCTGTT 
CGAGCCAAGG CCTTTGGATT CAGCGTCATA TTTTATGACC CCTACTTACA GGATGGGATA 
GAGCGGTCTC TGGGCGTGCA AAGGGTCTAC ACCCTGCAGG ACTTGTTATA TCAGAGCGAC 
TGTGTCTCCT TGCACTGCAA TCTGAATGAA CACAACCACC ACCTCATCAA TGACTTCACC 
ATCAAGCAGA TGAGGCAAGG AGCATTCCTT GTGAATGCAG CCCGAGGTGG CCTGGTGGAT 
GAGAAAGCCT TAGCTCAGGC CCTCAAAGAG GGCAGGATAC GAGGCGCTGC TCTGGATGTG 
CATGAGTCTG AGCCCTTCAG CTTTGCTCAG GGCCCATTGA AGGATGCTCC AAATCTCATC 
TGCACACCAC ACACAGCCTG GTACAGCGAA CAAGCATCAC TAGAGATGAG GGAAGCAGCT 
GCCACGGAGA TCCGCCGAGC AATCACAGGT CGCATTCCAG AAAGCTTACG AAACTGTGTC 
AACAAAGAAT TCTTTGTTAC TTCAACTCCT TGGTCAGTCA TTGACCAGCA AGCAATTCAT 
CCTGAGCTCA ATGGTGCCAC ATACAGGTAT CCACCAGGCA TTGTAGGTGT GGCTCCAGGA 
GGGCTTCCTC CAGCTATGGA AGGGATCATC CCTGGAGGCA TCCCTGTGAC TCACAACCTC 
CCCACTGTGG CACACCCTTC CCAAGCTCCC TCCCCAAACC AGCCCACAAA ACACGGGGAC 
AATCGAGAGC ACCCCAACGA GCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445787.1
CDS	59..3025
Translation	MPVPSRHINIGRSQSWDAAGWYEGPWENAGPPGRRSSLTYGPGEGVWCELVNHRAQDTESCLSREAFYNSLASRKGSVPDFTFYDSRQAVMSGRGSVLPQDYYGDPSRGTRVPKEPPFYRDPGTSRPVPSYGVLGSRIPWEQVQGQLPALQDAGHLYRESGSKTVLHGQRTHCRAPSPGRYGREQPDSRLGIEVPTYSPNSSQVYNDICERPVDSTHARQVAPTCLVVDPSSTAPTENSTGVAPGSLNRGYGPTRESIHSKLAYENYEADLSTFQGPGGKRTVYPEFLALLRAEGVAEATLAALLQQGFDSPAVLATLEDADIKSVAPNLGQARVLSRLVSSCRTEMQFRRQDRTGPPPRHRSSSFSHRSELLPNDTASLGTTALQFHPAGPLQTPSPRGGDLGRRPSSAPSQHLLETAATYSAPVVGSQTPHLPSNSGYSSPTPCALTARLASSYPSQAGVALTANPGPSVPLHSSPRTAYSTSYTVPMELLKRERSVTASPLPSPHASPQLLRKPGAAPVEPAALPPVRQSLHTPHPPYQKVARRTGAPIIVSTMLTPEPSIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSTPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPPAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ

Target ORF information:

RefSeq Version	NM_053335.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-terminal binding protein 2 (Ctbp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053335.1

ORF Insert Sequence:

ATGCCGGTTC CCAGCAGGCA CATCAACATT GGCCGTTCTC AGAGCTGGGA TGCCGCTGGC 
TGGTATGAGG GCCCTTGGGA GAATGCTGGC CCTCCAGGGA GGAGAAGTTC TCTGACTTAT 
GGCCCTGGAG AAGGGGTCTG GTGTGAGCTG GTAAACCACC GTGCCCAGGA CACTGAGTCC 
TGCCTGTCCC GGGAAGCTTT TTATAACTCA CTGGCATCAA GAAAGGGCTC CGTGCCTGAC 
TTCACCTTCT ACGACAGCAG GCAGGCAGTG ATGTCTGGCC GTGGCTCCGT GCTGCCACAA 
GACTACTATG GCGACCCATC CAGGGGCACC AGGGTACCCA AGGAGCCTCC CTTCTATCGG 
GACCCAGGAA CCAGCCGGCC GGTGCCCAGC TACGGAGTGC TGGGCAGCAG AATACCATGG 
GAGCAGGTAC AAGGCCAGTT ACCTGCTCTG CAGGATGCTG GCCACCTGTA CCGGGAATCT 
GGGAGTAAAA CTGTCCTGCA TGGGCAGCGG ACACACTGCA GGGCTCCATC TCCTGGGAGG 
TATGGAAGGG AACAACCTGA TTCTAGATTA GGGATAGAGG TACCCACCTA TTCCCCCAAC 
TCCAGCCAGG TCTACAACGA TATCTGCGAA AGACCCGTTG ACTCTACCCA TGCCAGACAG 
GTGGCCCCAA CATGCCTGGT TGTGGACCCC AGCTCGACCG CCCCTACTGA GAACAGCACG 
GGGGTGGCCC CAGGTTCCCT GAATAGAGGC TACGGGCCTA CCCGAGAAAG CATCCATTCA 
AAGCTGGCTT ATGAGAATTA TGAAGCCGAC TTGTCAACAT TCCAAGGACC CGGGGGCAAG 
AGGACCGTCT ACCCTGAGTT TTTGGCCCTG CTGAGGGCAG AGGGTGTGGC AGAGGCTACC 
CTGGCAGCCC TGTTACAACA AGGCTTTGAC TCCCCAGCTG TCTTGGCCAC CCTAGAGGAT 
GCTGACATCA AGTCTGTTGC CCCCAACCTG GGCCAGGCCC GTGTCCTGAG CCGCCTGGTC 
AGCAGCTGCA GGACAGAGAT GCAGTTTCGG CGACAGGACC GGACAGGCCC TCCACCCCGC 
CATCGGTCCA GTAGCTTCAG CCACCGAAGT GAGCTGCTGC CCAATGACAC GGCCTCGCTG 
GGGACCACAG CACTGCAGTT TCACCCAGCT GGACCTTTGC AGACACCCTC TCCCCGAGGT 
GGAGATCTAG GTCGCCGCCC CTCCAGTGCA CCTTCCCAGC ACCTCCTGGA GACAGCAGCT 
ACTTACTCTG CCCCAGTGGT GGGGTCCCAG ACTCCCCACT TACCCTCCAA CTCTGGATAT 
AGCTCTCCTA CCCCTTGTGC CCTAACAGCA CGACTGGCCT CCTCCTACCC TTCACAAGCT 
GGGGTAGCCT TGACTGCTAA CCCAGGCCCC TCTGTCCCCC TTCACTCAAG TCCCAGAACA 
GCCTATTCCA CCTCCTACAC GGTGCCCATG GAACTGCTTA AGAGGGAACG CAGTGTGACC 
GCCTCTCCGC TGCCCAGCCC CCATGCCAGC CCCCAGCTTC TGCGGAAACC TGGAGCAGCC 
CCCGTGGAGC CGGCTGCCCT GCCACCAGTC AGGCAAAGTC TCCACACACC TCATCCGCCA 
TACCAGAAGG TGGCCCGGCG GACAGGGGCT CCCATCATCG TGTCAACCAT GCTAACACCA 
GAACCAAGTA TCCGCCCCCA GATCATGAAC GGCCCCCTGC ACCCCCGCCC CCTAGTGGCA 
CTGCTGGATG GCAGAGACTG CACTGTGGAA ATGCCCATCC TGAAGGACCT GGCCACTGTG 
GCCTTCTGTG ATGCACAGTC CACTCAGGAA ATCCATGAGA AGGTATTGAA TGAGGCTGTG 
GGCGCCATGA TGTACCACAC CATCACTCTC ACCCGGGAAG ACCTGGAGAA GTTCAAGGCC 
CTGAGAGTGA TTGTTCGAAT CGGTAGTGGC TACGACAATG TGGACATCAA GGCTGCTGGC 
GAACTCGGAA TCGCCGTGTG CAACATCCCA TCTGCTGCAG TGGAGGAGAC AGCAGATTCG 
ACAGTCTGCC ATATCCTCAA TCTGTATCGG CGGAACACAT GGCTGTACCA GGCCCTACGA 
GAAGGCACGC GGGTACAAAG CGTGGAACAG ATCCGTGAGG TCGCCTCAGG AGCTGCTCGG 
ATCCGAGGGG AAACACTGGG CCTCATTGGC TTTGGTCGCA CTGGGCAGGC AGTTGCTGTT 
CGAGCCAAGG CCTTTGGATT CAGCGTCATA TTTTATGACC CCTACTTACA GGATGGGATA 
GAGCGGTCTC TGGGCGTGCA AAGGGTCTAC ACCCTGCAGG ACTTGTTATA TCAGAGCGAC 
TGTGTCTCCT TGCACTGCAA TCTGAATGAA CACAACCACC ACCTCATCAA TGACTTCACC 
ATCAAGCAGA TGAGGCAAGG AGCATTCCTT GTGAATGCAG CCCGAGGTGG CCTGGTGGAT 
GAGAAAGCCT TAGCTCAGGC CCTCAAAGAG GGCAGGATAC GAGGCGCTGC TCTGGATGTG 
CATGAGTCTG AGCCCTTCAG CTTTGCTCAG GGCCCATTGA AGGATGCTCC AAATCTCATC 
TGCACACCAC ACACAGCCTG GTACAGCGAA CAAGCATCAC TAGAGATGAG GGAAGCAGCT 
GCCACGGAGA TCCGCCGAGC AATCACAGGT CGCATTCCAG AAAGCTTACG AAACTGTGTC 
AACAAAGAAT TCTTTGTTAC TTCAACTCCT TGGTCAGTCA TTGACCAGCA AGCAATTCAT 
CCTGAGCTCA ATGGTGCCAC ATACAGGTAT CCACCAGGCA TTGTAGGTGT GGCTCCAGGA 
GGGCTTCCTC CAGCTATGGA AGGGATCATC CCTGGAGGCA TCCCTGTGAC TCACAACCTC 
CCCACTGTGG CACACCCTTC CCAAGCTCCC TCCCCAAACC AGCCCACAAA ACACGGGGAC 
AATCGAGAGC ACCCCAACGA GCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release.
The EMBO journal35(10)1098-114(2016 05)
Maxeiner S,Luo F,Tan A,Schmitz F,Südhof TC

Oxygen-dependent acetylation and dimerization of the corepressor CtBP2 in neural stem cells.
Experimental cell research332(1)128-35(2015 Mar)
Karaca E,Lewicki J,Hermanson O

The role of C-terminal binding protein 2 in Schwann cell differentiation after sciatic nerve crush.
Journal of molecular neuroscience : MN49(3)531-8(2013 Mar)
Cao X,Zhao P,Tao G,Zhu Y,Zhou F,Cui Z,Bao G,Xu D,Zhang G,Chen X

Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration.
The Journal of biological chemistry288(13)9028-34(2013 Mar)
Wang Y,Liu F,Mao F,Hang Q,Huang X,He S,Wang Y,Cheng C,Wang H,Xu G,Zhang T,Shen A

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Genes & development22(10)1397-409(2008 May)
Kajimura S,Seale P,Tomaru T,Erdjument-Bromage H,Cooper MP,Ruas JL,Chin S,Tempst P,Lazar MA,Spiegelman BM

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Ctbp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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