Ticam2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ticam2
Entrez Gene ID	364867
Full Name	toll-like receptor adaptor molecule 2
General protein information	Preferred Names toll-like receptor adaptor molecule 2 Names TIR domain-containing adapter molecule 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108890.1	NP_001102360.1	TIR domain-containing adapter molecule 2
XM_006254690.3	XP_006254752.1	TIR domain-containing adapter molecule 2 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TICAM2	NP_001191266.1
Mus musculus (house mouse)	Ticam2	NP_775570.1
Homo sapiens (human)	TICAM2	NP_067681.1
Pan troglodytes (chimpanzee)	TICAM2	NP_001182133.1
Bos taurus (cattle)	TICAM2	NP_001039921.1
Rattus norvegicus (Norway rat)	Ticam2	NP_001102360.1

Gene Ontology
Bibliography

Related articles in PubMed

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
Skjesol A, Yurchenko M, Bösl K, Gravastrand C, Nilsen KE, Grøvdal LM, Agliano F, Patane F, Lentini G, Kim H, Teti G, Kumar Sharma A, Kandasamy RK, Sporsheim B, Starheim KK, Golenbock DT, Stenmark H, McCaffrey M, Espevik T, Husebye H
PLoS pathogens15(3)e1007684(2019 03)

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse.
Liao J, Jijon HB, Kim IR, Goel G, Doan A, Sokol H, Bauer H, Herrmann BG, Lassen KG, Xavier RJ
PloS one9(9)e108777(2014)

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.
Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N
PloS one7(6)e38423(2012)

Pathogen recognition by the innate immune system.
Kumar H, Kawai T, Akira S
International reviews of immunology30(1)16-34(2011 Feb)

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
Palsson-McDermott EM, Doyle SL, McGettrick AF, Hardy M, Husebye H, Banahan K, Gong M, Golenbock D, Espevik T, O'Neill LA
Nature immunology10(6)579-86(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ticam2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ticam2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08575	NM_001108890.1 Latest version!	Rattus norvegicus toll-like receptor adaptor molecule 2 (Ticam2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa08575	XM_006254690.3 Latest version!	Rattus norvegicus toll-like receptor adaptor molecule 2 (Ticam2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ticam2 ( NM_001108890.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102360.1 Rattus norvegicus toll-like receptor adaptor molecule 2 (Ticam2), mRNA.

Price & Availability↑

CloneID	ORa08575
Clone ID Related Accession (Same CDS sequence)	NM_001108890.1 , XM_006254690.3
Accession Version	NM_001108890.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570636800000
Organism	Rattus norvegicus(Norway rat)
Product	TIR domain-containing adapter molecule 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473971.1. On or before Oct 4, 2007 this sequence version replaced XM_344681.3, XM_001054397.1. ##Evidence-Data-START## CDS exon combination :: BF286065.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGGTGTTG GGAAGTCTAA ACTAGATAAG TGCCCTCTTT CTTGGCATAA AAGAGACAGT 
GTGGATGGCG ATCAAGGCTG CCATGAGTCA GACTCCAAGA ACTCTGAGAA TGCGTCCTCG 
CCTGCTTTTG TGGTGCATAG CAATGGAGTA GAACAGCCAA TAGGGGAGCA GGACAGACCC 
GAGGCAAAGG GGGAGGGGCA TGAGGAGCAA GCTGAAGAAG AGTTCCTCAA ATTTGTGATA 
CTGCACGCAG AAGATGACAC CAACGAGGCC CTCCGAGTCC AGAATCTACT GCAAAACGAC 
TTTGGTATCA GGCCTGGGAT AGTCTTCGCC GAGATGCCAT GCGGAAGACT GCACTTGCAG 
AATCTAGACG ATGCGGTAAA TGGGTCCGCC TGGACGATCT TGTTACTGAC TGAGAACTTC 
TTAAGAGACA CCTGGTGCAA CTTCCAGTTC TACACTTCCC TGATGAATTC TGTGAACAGG 
CAACACAAGT ACAATTCCGT CATACCTATG CGGCCCCTGA ACAGTCCTCT TCCCAGGGAA 
AGGACTCCGT TGGCGCTGCA AACCATCAAT GCCTTAGAGG AAGAAAGCCA AGGCTTTTCC 
ACACAAGTGG AGAGGATTTT CCGGGAATCT GTGTATGAGA GGCAACAAAG TGTATGGAAG 
GAGACACGAA GTGTGACACA GAGACAGTTC ATTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102360.1
CDS	475..1173
Translation	MGVGKSKLDKCPLSWHKRDSVDGDQGCHESDSKNSENASSPAFVVHSNGVEQPIGEQDRPEAKGEGHEEQAEEEFLKFVILHAEDDTNEALRVQNLLQNDFGIRPGIVFAEMPCGRLHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVNRQHKYNSVIPMRPLNSPLPRERTPLALQTINALEEESQGFSTQVERIFRESVYERQQSVWKETRSVTQRQFIA

Target ORF information:

RefSeq Version	NM_001108890.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus toll-like receptor adaptor molecule 2 (Ticam2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108890.1

ORF Insert Sequence:

ATGGGTGTTG GGAAGTCTAA ACTAGATAAG TGCCCTCTTT CTTGGCATAA AAGAGACAGT 
GTGGATGGCG ATCAAGGCTG CCATGAGTCA GACTCCAAGA ACTCTGAGAA TGCGTCCTCG 
CCTGCTTTTG TGGTGCATAG CAATGGAGTA GAACAGCCAA TAGGGGAGCA GGACAGACCC 
GAGGCAAAGG GGGAGGGGCA TGAGGAGCAA GCTGAAGAAG AGTTCCTCAA ATTTGTGATA 
CTGCACGCAG AAGATGACAC CAACGAGGCC CTCCGAGTCC AGAATCTACT GCAAAACGAC 
TTTGGTATCA GGCCTGGGAT AGTCTTCGCC GAGATGCCAT GCGGAAGACT GCACTTGCAG 
AATCTAGACG ATGCGGTAAA TGGGTCCGCC TGGACGATCT TGTTACTGAC TGAGAACTTC 
TTAAGAGACA CCTGGTGCAA CTTCCAGTTC TACACTTCCC TGATGAATTC TGTGAACAGG 
CAACACAAGT ACAATTCCGT CATACCTATG CGGCCCCTGA ACAGTCCTCT TCCCAGGGAA 
AGGACTCCGT TGGCGCTGCA AACCATCAAT GCCTTAGAGG AAGAAAGCCA AGGCTTTTCC 
ACACAAGTGG AGAGGATTTT CCGGGAATCT GTGTATGAGA GGCAACAAAG TGTATGGAAG 
GAGACACGAA GTGTGACACA GAGACAGTTC ATTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ticam2 ( XM_006254690.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254752.1 Rattus norvegicus toll-like receptor adaptor molecule 2 (Ticam2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa08575
Clone ID Related Accession (Same CDS sequence)	NM_001108890.1 , XM_006254690.3
Accession Version	XM_006254690.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	TIR domain-containing adapter molecule 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254690.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTGTTG GGAAGTCTAA ACTAGATAAG TGCCCTCTTT CTTGGCATAA AAGAGACAGT 
GTGGATGGCG ATCAAGGCTG CCATGAGTCA GACTCCAAGA ACTCTGAGAA TGCGTCCTCG 
CCTGCTTTTG TGGTGCATAG CAATGGAGTA GAACAGCCAA TAGGGGAGCA GGACAGACCC 
GAGGCAAAGG GGGAGGGGCA TGAGGAGCAA GCTGAAGAAG AGTTCCTCAA ATTTGTGATA 
CTGCACGCAG AAGATGACAC CAACGAGGCC CTCCGAGTCC AGAATCTACT GCAAAACGAC 
TTTGGTATCA GGCCTGGGAT AGTCTTCGCC GAGATGCCAT GCGGAAGACT GCACTTGCAG 
AATCTAGACG ATGCGGTAAA TGGGTCCGCC TGGACGATCT TGTTACTGAC TGAGAACTTC 
TTAAGAGACA CCTGGTGCAA CTTCCAGTTC TACACTTCCC TGATGAATTC TGTGAACAGG 
CAACACAAGT ACAATTCCGT CATACCTATG CGGCCCCTGA ACAGTCCTCT TCCCAGGGAA 
AGGACTCCGT TGGCGCTGCA AACCATCAAT GCCTTAGAGG AAGAAAGCCA AGGCTTTTCC 
ACACAAGTGG AGAGGATTTT CCGGGAATCT GTGTATGAGA GGCAACAAAG TGTATGGAAG 
GAGACACGAA GTGTGACACA GAGACAGTTC ATTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254752.1
CDS	700..1398
Translation	MGVGKSKLDKCPLSWHKRDSVDGDQGCHESDSKNSENASSPAFVVHSNGVEQPIGEQDRPEAKGEGHEEQAEEEFLKFVILHAEDDTNEALRVQNLLQNDFGIRPGIVFAEMPCGRLHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVNRQHKYNSVIPMRPLNSPLPRERTPLALQTINALEEESQGFSTQVERIFRESVYERQQSVWKETRSVTQRQFIA

Target ORF information:

RefSeq Version	XM_006254690.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus toll-like receptor adaptor molecule 2 (Ticam2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254690.3

ORF Insert Sequence:

ATGGGTGTTG GGAAGTCTAA ACTAGATAAG TGCCCTCTTT CTTGGCATAA AAGAGACAGT 
GTGGATGGCG ATCAAGGCTG CCATGAGTCA GACTCCAAGA ACTCTGAGAA TGCGTCCTCG 
CCTGCTTTTG TGGTGCATAG CAATGGAGTA GAACAGCCAA TAGGGGAGCA GGACAGACCC 
GAGGCAAAGG GGGAGGGGCA TGAGGAGCAA GCTGAAGAAG AGTTCCTCAA ATTTGTGATA 
CTGCACGCAG AAGATGACAC CAACGAGGCC CTCCGAGTCC AGAATCTACT GCAAAACGAC 
TTTGGTATCA GGCCTGGGAT AGTCTTCGCC GAGATGCCAT GCGGAAGACT GCACTTGCAG 
AATCTAGACG ATGCGGTAAA TGGGTCCGCC TGGACGATCT TGTTACTGAC TGAGAACTTC 
TTAAGAGACA CCTGGTGCAA CTTCCAGTTC TACACTTCCC TGATGAATTC TGTGAACAGG 
CAACACAAGT ACAATTCCGT CATACCTATG CGGCCCCTGA ACAGTCCTCT TCCCAGGGAA 
AGGACTCCGT TGGCGCTGCA AACCATCAAT GCCTTAGAGG AAGAAAGCCA AGGCTTTTCC 
ACACAAGTGG AGAGGATTTT CCGGGAATCT GTGTATGAGA GGCAACAAAG TGTATGGAAG 
GAGACACGAA GTGTGACACA GAGACAGTTC ATTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
PLoS pathogens15(3)e1007684(2019 03)
Skjesol A,Yurchenko M,Bösl K,Gravastrand C,Nilsen KE,Grøvdal LM,Agliano F,Patane F,Lentini G,Kim H,Teti G,Kumar Sharma A,Kandasamy RK,Sporsheim B,Starheim KK,Golenbock DT,Stenmark H,McCaffrey M,Espevik T,Husebye H

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse.
PloS one9(9)e108777(2014)
Liao J,Jijon HB,Kim IR,Goel G,Doan A,Sokol H,Bauer H,Herrmann BG,Lassen KG,Xavier RJ

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.
PloS one7(6)e38423(2012)
Ohnishi H,Tochio H,Kato Z,Kawamoto N,Kimura T,Kubota K,Yamamoto T,Funasaka T,Nakano H,Wong RW,Shirakawa M,Kondo N

Pathogen recognition by the innate immune system.
International reviews of immunology30(1)16-34(2011 Feb)
Kumar H,Kawai T,Akira S

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
Nature immunology10(6)579-86(2009 Jun)
Palsson-McDermott EM,Doyle SL,McGettrick AF,Hardy M,Husebye H,Banahan K,Gong M,Golenbock D,Espevik T,O'Neill LA

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Ticam2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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