Wwp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Wwp2
Entrez Gene ID	291999
Full Name	WW domain containing E3 ubiquitin protein ligase 2
General protein information	Preferred Names WW domain containing E3 ubiquitin protein ligase 2 Names NEDD4-like E3 ubiquitin-protein ligase WWP2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106184.1	NP_001099654.1	NEDD4-like E3 ubiquitin-protein ligase WWP2

Pathways from BioSystems

Homologies

Homo sapiens (human)	WWP2	NP_001257383.1
Macaca mulatta (Rhesus monkey)	WWP2	XP_001101869.1
Gallus gallus (chicken)	WWP2	NP_001034349.1
Xenopus tropicalis (tropical clawed frog)	wwp2	NP_001090841.1
Rattus norvegicus (Norway rat)	Wwp2	NP_001099654.1
Canis lupus familiaris (dog)	WWP2	XP_851140.3
Danio rerio (zebrafish)	wwp2	NP_001092918.1
Bos taurus (cattle)	WWP2	NP_001076883.1
Mus musculus (house mouse)	Wwp2	NP_080106.1

Gene Ontology
Bibliography

Related articles in PubMed

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.
Yuan L, Lv Y, Li H, Gao H, Song S, Zhang Y, Xing G, Kong X, Wang L, Li Y, Zhou T, Gao D, Xiao ZX, Yin Y, Wei W, He F, Zhang L
Nature cell biology17(9)1169-81(2015 Sep)

Protein microarray characterization of the S-nitrosoproteome.
Lee YI, Giovinazzo D, Kang HC, Lee Y, Jeong JS, Doulias PT, Xie Z, Hu J, Ghasemi M, Ischiropoulos H, Qian J, Zhu H, Blackshaw S, Dawson VL, Dawson TM
Molecular & cellular proteomics : MCP13(1)63-72(2014 Jan)

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.
Nabhan JF, Hu R, Oh RS, Cohen SN, Lu Q
Proceedings of the National Academy of Sciences of the United States of America109(11)4146-51(2012 Mar)

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25.
Nakamura Y, Yamamoto K, He X, Otsuki B, Kim Y, Murao H, Soeda T, Tsumaki N, Deng JM, Zhang Z, Behringer RR, Crombrugghe Bd, Postlethwait JH, Warman ML, Nakamura T, Akiyama H
Nature communications2251(2011)

Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.
Liao B, Jin Y
Cell research20(3)332-44(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Wwp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Wwp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41439	NM_001106184.1 Latest version!	Rattus norvegicus WW domain containing E3 ubiquitin protein ligase 2 (Wwp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Wwp2 ( NM_001106184.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099654.1 Rattus norvegicus WW domain containing E3 ubiquitin protein ligase 2 (Wwp2), mRNA.

Price & Availability↑

CloneID	ORa41439
Clone ID Related Accession (Same CDS sequence)	NM_001106184.1
Accession Version	NM_001106184.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2613bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1530288000000
Organism	Rattus norvegicus(Norway rat)
Product	NEDD4-like E3 ubiquitin-protein ligase WWP2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473972.1. On or before Oct 4, 2007 this sequence version replaced XM_001076615.1, XM_214669.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGCGTCTG CCAGCTCCAG CCGGGCGGGG GTGGCCCTGC CTTTTGAGAA GTCCCAGCTT 
ACTCTGAGAG TGGTGTCAGC AAAGCCCAAG GTGCACAACC GCCAGCCCAG AATCAACTCC 
TATGTGGAGG TGGCAGTGGA TGGACTCCCC AGTGAGACCA AGAAGACTGG GAAGCGCATC 
GGGAGCTCTG AGCTTCTCTG GAATGAAGTC ATCGTTCTGA ATGTTACAGC CCAGAGTCAT 
TTAGATTTGA AGGTCTGGAG CTGTCATACC TTGAGGAATG AACTACTGGG CACTGCCTCT 
GTCAACCTCT CCAATGTCCT GAAGAACAAT GGCGGCAAAA TGGAGAACAC GCAACTGACC 
CTGAACCTGC AGACAGAGAA CAAAGGCAGC GTTGTCTCAG GAGGAGAGCT GACAATTTTC 
CTGGATGGGC CAACTGTTGA TCTGGGCAGT GTGCCTAATG GCAGTGCAGT GACAGACGGA 
TCACAACCAC CTTCAAGAGA ATCCAGTGGG ACTGCTCTAG CTCCAGAGAC CCGGCACCAG 
CCCCCCAGTA CAAACTGCTT TGGTGGCAGA TCCCGGACGC ACAGACATTC AGGTGGCTCA 
GCCAGGACAG CCACAGCAAC TGGCGAACAA AGTCCTGGTG CTAGGAACCG CCACCGCCAA 
CCTGTGAAGA ACCCCAGCAG CAGTGGCTTA GCCAATGGCA CAGTGAGTGA GGAACCTACG 
ACAGCCAGCG ATCCTGAAGA ACTGTCGGTT GTTGGTGTGA CATCGCCGCC TGCTGCAGCC 
TCCAGTGTGT CCCCAAATCC CAACACGACA TCTCTCCCTG CACCGTCCAC ACCAGCTGAG 
GGAGAAGAGC CCAGCACTTC CGGGACACAG CAGCTCCCTG CTGCTGCCCA GGCCCCTGAT 
GCTCTTCCTG CTGGATGGGA ACAGAGACAG CTGCCCAATG GGCGTGTCTA TTATGTTGAT 
CACAATACCA AGACCACCAC CTGGGAGCGG CCTCTTCCTC CAGGATGGGA AAAGCGCACA 
GACCCCCGAG GGAGGTTTTA CTACGTGGAC CACAACACCC GGACAACCAC CTGGCAGCGC 
CCGACTGCTG AGTACGTGCG GAACTATGAG CAGTGGCAGT CACAGCGGAA TCAGCTGCAG 
GGGGCCATGC AGCACTTCAG CCAAAGATTC CTCTACCAGT CTTCGAGTGC TTCGACTGAC 
CATGATCCCT TGGGCCCCCT CCCGCCTGGC TGGGAGAAGA GGCAGGACAA TGGCCGGGTG 
TATTACGTGA ACCACAACAC ACGCACTACC CAATGGGAGG ACCCGCGGAC GCAGGGAATG 
ATACAGGAGC CAGCCCTGCC CCCAGGGTGG GAGATGAAGT ACACCAGCGA GGGCGTGCGG 
TACTTTGTGG ATCACAACAC CCGCACTACC ACCTTTAAGG ATCCTCGCCC AGGGTTCGAG 
TCAGGGACAA AGCAGGGCTC GCCTGGTGCC TATGAGCGAA GTTTCCGGTG GAAGTATCAC 
CAGTTCCGCT TCCTCTGCCA CTCAAATGCC CTACCCAGCC ACGTGAAGAT CAGCGTTTCC 
AGGCAGACTC TCTTTGAGGA TTCTTTCCAA CAGATTATGA ACATGAAACC TTACGACCTG 
CGCCGCCGGC TCTACATCAT CATGCGTGGT GAGGAGGGCC TGGACTACGG CGGCATCGCC 
AGAGAGTGGT TTTTCCTCCT GTCCCATGAG GTGCTCAACC CTATGTACTG TTTGTTTGAA 
TATGCTGGGA AGAACAATTA CTGCCTGCAG ATCAACCCGG CCTCTTCCAT CAACCCTGAC 
CACCTCACCT ACTTCCGCTT TATCGGCAGA TTCATCGCCA TGGCTCTGTA CCATGGAAAG 
TTCATCGACA CAGGCTTCAC CCTCCCTTTC TACAAGCGGA TGCTCAACAA GAGACCAACT 
CTCAGGGACC TGGAGTCTAT TGACCCTGAG TTTTACAACT CCATTATCTG GATCAAAGAG 
AACAACCTGG ATGAGTGTGG CCTGGAGCTG TTCTTCATCC AGGACATGGA GATCCTGGGC 
AAGGTGACAA CCCATGAACT GAAGGAAGGC GGAGAGAACA TCCGAGTTAC TGAGGAGAAC 
AAGGAGGAGT ATATCATGCT GCTGACTGAC TGGCGATTCA CCCGAGGTGT GGAAGAGCAG 
ACCAAAGCCT TCCTGGATGG CTTCAATGAG GTGGCCCCTC TGGAGTGGTT GAGATATTTT 
GATGAAAAAG AGCTGGAGCT CATGCTGTGT GGCATGCAGG AGATTGACAT GAGTGACTGG 
CAGAAGAACG CCATCTATCG GCACTACACC AAGAGCAGCA AGCAGATCCA GTGGTTCTGG 
CAGGTTGTGA AGGAGATGGA CAATGAGAAG AGGATCCGGC TACTGCAGTT TGTCACGGGA 
ACCTGCCGCC TGCCTGTTGG GGGCTTTGCT GAGCTCATTG GGAGCAATGG ACCCCAGAAG 
TTCTGCATTG ACAGAGTTGG CAAGGAAACC TGGCTGCCTA GGAGCCATAC ATGCTTCAAC 
CGCCTGGATC TGCCTCCCTA CAAGAGCTAC GAGCAGCTGA AAGAGAAGCT GCTGTATGCC 
ATCGAGGAGA CTGAGGGTTT TGGACAGGAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099654.1
CDS	81..2693
Translation	MASASSSRAGVALPFEKSQLTLRVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEVIVLNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENTQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGSVPNGSAVTDGSQPPSRESSGTALAPETRHQPPSTNCFGGRSRTHRHSGGSARTATATGEQSPGARNRHRQPVKNPSSSGLANGTVSEEPTTASDPEELSVVGVTSPPAAASSVSPNPNTTSLPAPSTPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRQLPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYERSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLRDLESIDPEFYNSIIWIKENNLDECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE

Target ORF information:

RefSeq Version	NM_001106184.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus WW domain containing E3 ubiquitin protein ligase 2 (Wwp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106184.1

ORF Insert Sequence:

ATGGCGTCTG CCAGCTCCAG CCGGGCGGGG GTGGCCCTGC CTTTTGAGAA GTCCCAGCTT 
ACTCTGAGAG TGGTGTCAGC AAAGCCCAAG GTGCACAACC GCCAGCCCAG AATCAACTCC 
TATGTGGAGG TGGCAGTGGA TGGACTCCCC AGTGAGACCA AGAAGACTGG GAAGCGCATC 
GGGAGCTCTG AGCTTCTCTG GAATGAAGTC ATCGTTCTGA ATGTTACAGC CCAGAGTCAT 
TTAGATTTGA AGGTCTGGAG CTGTCATACC TTGAGGAATG AACTACTGGG CACTGCCTCT 
GTCAACCTCT CCAATGTCCT GAAGAACAAT GGCGGCAAAA TGGAGAACAC GCAACTGACC 
CTGAACCTGC AGACAGAGAA CAAAGGCAGC GTTGTCTCAG GAGGAGAGCT GACAATTTTC 
CTGGATGGGC CAACTGTTGA TCTGGGCAGT GTGCCTAATG GCAGTGCAGT GACAGACGGA 
TCACAACCAC CTTCAAGAGA ATCCAGTGGG ACTGCTCTAG CTCCAGAGAC CCGGCACCAG 
CCCCCCAGTA CAAACTGCTT TGGTGGCAGA TCCCGGACGC ACAGACATTC AGGTGGCTCA 
GCCAGGACAG CCACAGCAAC TGGCGAACAA AGTCCTGGTG CTAGGAACCG CCACCGCCAA 
CCTGTGAAGA ACCCCAGCAG CAGTGGCTTA GCCAATGGCA CAGTGAGTGA GGAACCTACG 
ACAGCCAGCG ATCCTGAAGA ACTGTCGGTT GTTGGTGTGA CATCGCCGCC TGCTGCAGCC 
TCCAGTGTGT CCCCAAATCC CAACACGACA TCTCTCCCTG CACCGTCCAC ACCAGCTGAG 
GGAGAAGAGC CCAGCACTTC CGGGACACAG CAGCTCCCTG CTGCTGCCCA GGCCCCTGAT 
GCTCTTCCTG CTGGATGGGA ACAGAGACAG CTGCCCAATG GGCGTGTCTA TTATGTTGAT 
CACAATACCA AGACCACCAC CTGGGAGCGG CCTCTTCCTC CAGGATGGGA AAAGCGCACA 
GACCCCCGAG GGAGGTTTTA CTACGTGGAC CACAACACCC GGACAACCAC CTGGCAGCGC 
CCGACTGCTG AGTACGTGCG GAACTATGAG CAGTGGCAGT CACAGCGGAA TCAGCTGCAG 
GGGGCCATGC AGCACTTCAG CCAAAGATTC CTCTACCAGT CTTCGAGTGC TTCGACTGAC 
CATGATCCCT TGGGCCCCCT CCCGCCTGGC TGGGAGAAGA GGCAGGACAA TGGCCGGGTG 
TATTACGTGA ACCACAACAC ACGCACTACC CAATGGGAGG ACCCGCGGAC GCAGGGAATG 
ATACAGGAGC CAGCCCTGCC CCCAGGGTGG GAGATGAAGT ACACCAGCGA GGGCGTGCGG 
TACTTTGTGG ATCACAACAC CCGCACTACC ACCTTTAAGG ATCCTCGCCC AGGGTTCGAG 
TCAGGGACAA AGCAGGGCTC GCCTGGTGCC TATGAGCGAA GTTTCCGGTG GAAGTATCAC 
CAGTTCCGCT TCCTCTGCCA CTCAAATGCC CTACCCAGCC ACGTGAAGAT CAGCGTTTCC 
AGGCAGACTC TCTTTGAGGA TTCTTTCCAA CAGATTATGA ACATGAAACC TTACGACCTG 
CGCCGCCGGC TCTACATCAT CATGCGTGGT GAGGAGGGCC TGGACTACGG CGGCATCGCC 
AGAGAGTGGT TTTTCCTCCT GTCCCATGAG GTGCTCAACC CTATGTACTG TTTGTTTGAA 
TATGCTGGGA AGAACAATTA CTGCCTGCAG ATCAACCCGG CCTCTTCCAT CAACCCTGAC 
CACCTCACCT ACTTCCGCTT TATCGGCAGA TTCATCGCCA TGGCTCTGTA CCATGGAAAG 
TTCATCGACA CAGGCTTCAC CCTCCCTTTC TACAAGCGGA TGCTCAACAA GAGACCAACT 
CTCAGGGACC TGGAGTCTAT TGACCCTGAG TTTTACAACT CCATTATCTG GATCAAAGAG 
AACAACCTGG ATGAGTGTGG CCTGGAGCTG TTCTTCATCC AGGACATGGA GATCCTGGGC 
AAGGTGACAA CCCATGAACT GAAGGAAGGC GGAGAGAACA TCCGAGTTAC TGAGGAGAAC 
AAGGAGGAGT ATATCATGCT GCTGACTGAC TGGCGATTCA CCCGAGGTGT GGAAGAGCAG 
ACCAAAGCCT TCCTGGATGG CTTCAATGAG GTGGCCCCTC TGGAGTGGTT GAGATATTTT 
GATGAAAAAG AGCTGGAGCT CATGCTGTGT GGCATGCAGG AGATTGACAT GAGTGACTGG 
CAGAAGAACG CCATCTATCG GCACTACACC AAGAGCAGCA AGCAGATCCA GTGGTTCTGG 
CAGGTTGTGA AGGAGATGGA CAATGAGAAG AGGATCCGGC TACTGCAGTT TGTCACGGGA 
ACCTGCCGCC TGCCTGTTGG GGGCTTTGCT GAGCTCATTG GGAGCAATGG ACCCCAGAAG 
TTCTGCATTG ACAGAGTTGG CAAGGAAACC TGGCTGCCTA GGAGCCATAC ATGCTTCAAC 
CGCCTGGATC TGCCTCCCTA CAAGAGCTAC GAGCAGCTGA AAGAGAAGCT GCTGTATGCC 
ATCGAGGAGA CTGAGGGTTT TGGACAGGAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.
Nature cell biology17(9)1169-81(2015 Sep)
Yuan L,Lv Y,Li H,Gao H,Song S,Zhang Y,Xing G,Kong X,Wang L,Li Y,Zhou T,Gao D,Xiao ZX,Yin Y,Wei W,He F,Zhang L

Protein microarray characterization of the S-nitrosoproteome.
Molecular & cellular proteomics : MCP13(1)63-72(2014 Jan)
Lee YI,Giovinazzo D,Kang HC,Lee Y,Jeong JS,Doulias PT,Xie Z,Hu J,Ghasemi M,Ischiropoulos H,Qian J,Zhu H,Blackshaw S,Dawson VL,Dawson TM

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.
Proceedings of the National Academy of Sciences of the United States of America109(11)4146-51(2012 Mar)
Nabhan JF,Hu R,Oh RS,Cohen SN,Lu Q

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25.
Nature communications2251(2011)
Nakamura Y,Yamamoto K,He X,Otsuki B,Kim Y,Murao H,Soeda T,Tsumaki N,Deng JM,Zhang Z,Behringer RR,Crombrugghe Bd,Postlethwait JH,Warman ML,Nakamura T,Akiyama H

Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.
Cell research20(3)332-44(2010 Mar)
Liao B,Jin Y

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Wwp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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