Atxn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atxn1
Entrez Gene ID	25049
Full Name	ataxin 1
Synonyms	Sca1
General protein information	Preferred Names ataxin 1 Names ataxin-1 spinocerebellar ataxia 1 spinocerebellar ataxia type 1 protein homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p14
Summary	human homolog contains an expanded CAG nucleotide repeat region that causes the neurodegenerative disorder spinocerebellar ataxia type 1 (SCA1) [RGD, Feb 2007].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012726.2	NP_036858.1	ataxin-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ATXN1	NP_001121636.1
Rattus norvegicus (Norway rat)	Atxn1	NP_036858.1
Xenopus tropicalis (tropical clawed frog)	atxn1	XP_004915340.1
Pan troglodytes (chimpanzee)	ATXN1	XP_003311077.1
Bos taurus (cattle)	ATXN1	XP_005223892.1
Mus musculus (house mouse)	Atxn1	NP_001186234.1
Danio rerio (zebrafish)	atxn1a	NP_001038291.1
Canis lupus familiaris (dog)	ATXN1	XP_545354.2
Gallus gallus (chicken)	ATXN1	XP_003640803.1

Gene Ontology
Bibliography

Related articles in PubMed

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.
Lu HC, Tan Q, Rousseaux MW, Wang W, Kim JY, Richman R, Wan YW, Yeh SY, Patel JM, Liu X, Lin T, Lee Y, Fryer JD, Han J, Chahrour M, Finnell RH, Lei Y, Zurita-Jimenez ME, Ahimaz P, Anyane-Yeboa K, Van Maldergem L, Lehalle D, Jean-Marcais N, Mosca-Boidron AL, Thevenon J, Cousin MA, Bro DE, Lanpher BC, Klee EW, Alexander N, Bainbridge MN, Orr HT, Sillitoe RV, Ljungberg MC, Liu Z, Schaaf CP, Zoghbi HY
Nature genetics49(4)527-536(2017 Apr)

ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY
Developmental cell21(4)746-57(2011 Oct)

Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
Crespo-Barreto J, Fryer JD, Shaw CA, Orr HT, Zoghbi HY
PLoS genetics6(7)e1001021(2010 Jul)

Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
Shiwaku H, Yoshimura N, Tamura T, Sone M, Ogishima S, Watase K, Tagawa K, Okazawa H
The EMBO journal29(14)2446-60(2010 Jul)

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.
Parfitt DA, Michael GJ, Vermeulen EG, Prodromou NV, Webb TR, Gallo JM, Cheetham ME, Nicoll WS, Blatch GL, Chapple JP
Human molecular genetics18(9)1556-65(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Atxn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atxn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42536	NM_012726.2 Latest version!	Rattus norvegicus ataxin 1 (Atxn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atxn1 ( NM_012726.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036858.1 Rattus norvegicus ataxin 1 (Atxn1), mRNA.

Price & Availability↑

CloneID	ORa42536
Clone ID Related Accession (Same CDS sequence)	NM_012726.2
Accession Version	NM_012726.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2370bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	ataxin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X91619.1. On Mar 2, 2007 this sequence version replaced NM_012726.1. Sequence Note: The sequence X91619.1 is from a chimeric clone. Only the ataxin 1 region was propagated into this RefSeq record. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGAAATCTA ACCAAGAGCG GAGCAATGAA TGCCTGCCTC CCAAGAAACG TGAGATCCCC 
GCCACCAGTC GGCCCTCCGA GGAGAAGGCC ACTGCTCTGC CCAGCGACAA CCACTGCGTG 
GAGGGTGTGG CATGGCTCCC CAGCACCCCT GGCAGCCGCG GCCACGGGGG TGGGCGGCAC 
GGGCCAGCAG GGACTTCCGG GGAACATGGT TTACAAGGAA TGGGTTTACA TAAAGCACTG 
TCCGCAGGGC TGGATTACTC CCCACCCAGT GCCCCCAGGT CGGTCCCCAC AGCCAACACG 
CTGCCCACCG TGTACCCTCC TCCTCAGTCA GGGACGCCGG TGTCTCCTGT GCAGTACGCC 
CACCTATCAC ATACCTTCCA GTTCATTGGG TCCTCCCAGT ATAGTGGGCC TTACGCGGGC 
TTTATCCCTT CCCAGCTGAT CTCCCCACCA GGCAACCCAG TCACCAGTGC GGTGGCCTCG 
GCTGCAGGGG CCACCACTCC ATCACAGCGC TCCCAGCTGG AGGCATATTC CACCCTGCTG 
GCCAACATGG GCAGTCTGAG CCAGGCACCA GGACACAAGG TTGAGCCCCC TCCGCAGCAG 
CACCTCGGCA GGGCTGCGGG ATTAGTCAAC CCGGGGTCCC CTCCACCTAC CCAGCAGAAC 
CAGTACATTC ACATTTCCAG CTCTCCGCAG AGCTCCGGGC GGGCAACATC TCCACCCATC 
CCGGTCCACC TCCATCCCCA TCAGACGATG ATCCCGCACA CGCTCACCCT GGGGCCTTCA 
TCCCAGGTGG TCGTGCAATA CAGTGACGCC GGAGGCCACT TTGTTCCTCG AGAGTCCACC 
AAAAAAGCAG AAAGCAGCAG GTTGCAGCAG GCTATGCAGG CCAAGGAGGT CCTCAATGGG 
GAGATGGAGA AAAGCCGGAG GTATGGGGCG TCATCTTCTG TGGAGCTGAG CCTGGGGAAG 
ACGAGCAGCA AGTCAGTGCC TCACCCCTAT GAGTCCAGGC ATGTGGTGGT CCACCCGAGC 
CCAGCAGACT ACAGCAGTCG TGATACCTCC GGGGTCCGTG GATCTGTGAT GGTCCTGCCC 
AACAGCAGCA CACCCTCAGC CGACCTGGAG ACACAGCAGG CCACACATCG AGAGGCCTCC 
CCATCCACCC TCAATGACAA GAGCGGTTTG CACCTAGGGA AGCCCGGCCA CAGGTCCTAC 
GCGCTGTCCC CGCACACGGT CATTCAGACC ACACACAGCG CATCAGAGCC TCTCCCGGTG 
GGCCTACCAG CCACGGCCTT CTATGCTGGC GCTCAACCTC CTGTCATCGG CTATCTGAGT 
AGCCAGCAGC AAGCAATCAC CTATGCTGGT GGTCTGCCCC AGCACCTGGT GATCCCAGGT 
ACCCAGCCCC TGCTCATCCC AGTGGGCAGC CCTGACATGG ACACACCTGG GGCAGCCTCG 
GCCATAGTGA CGTCATCGCC CCAGTTTGCT GCAGTACCTC ACACGTTTGT CACCACCGCC 
CTGCCCAAGA GCGAGAACTT CAACCCAGAG GCTCTGGTCA CCCAGGCAGC CTACCCAGCC 
ATGGTGCAGG CCCAGATCCA CCTGCCGGTG GTACAGTCCG TGGCATCCCC TGCCGCGGCA 
TCACCCACGC TGCCGCCATA TTTCATGAAA GGCTCCATCA TCCAGCTGGC CAACGGGGAG 
CTGAAGAAGG TAGAGGATCT GAAGACAGAG GATTTCATCC AGAGTGCAGA GATTAGCAAT 
GACCTCAAGA TCGACTCCAG TACTGTGGAG AGGATCGAGG ACAGCCACAG CCCCGGTGTG 
GCGGTGATAC AATTTGCTGT TGGTGAACAC CGAGCCCAGG TCAGTGTCGA AGTTTTGGTA 
GAGTATCCTT TTTTTGTATT TGGACAGGGC TGGTCATCCT GCTGTCCCGA GCGGACCAGC 
CAGCTCTTTG ATCTGCCGTG TTCCAAACTC TCCGTTGGGG ACGTCTGCAT CTCGCTCACC 
CTCAAGAACC TGAAGAATGG CTCTGTTAAA AAGGGCCAGC CCGTGGACCC TGCCAGTGCC 
CTGCTGAAGC ACGCAAAGAC CGACAGCCTG GCTGGCAGCA GACACAGATA CGCCGAGCAG 
GAAAACGGAA TCAACCAGGG GAGCGCCCAG GTGCTCTCTG AGAACGGCGA ACTGAAGTTT 
CCAGAAAAAA TTGGATTGCC TGCAGCACCC TTCCTCACCA AAATAGAACC GAGCAAGCCC 
ACAGCCACGA GGAAGAGGAG GTGGTCGGCG CCGGAGACCC GTAAACTGGA GAAGTCGGAG 
GACGAGCCAC CTTTGACTCT TCCCAAGCCT TCGCTCATTC CTCAGGAGGT TAAGATCTGC 
ATCGAAGGCC GATCTAACGT GGGCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036858.1
CDS	1024..3393
Translation	MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGSRGHGGGRHGPAGTSGEHGLQGMGLHKALSAGLDYSPPSAPRSVPTANTLPTVYPPPQSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPPGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPPPQQHLGRAAGLVNPGSPPPTQQNQYIHISSSPQSSGRATSPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGASSSVELSLGKTSSKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNSSTPSADLETQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGAQPPVIGYLSSQQQAITYAGGLPQHLVIPGTQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAASPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASALLKHAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLTKIEPSKPTATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK

Target ORF information:

RefSeq Version	NM_012726.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ataxin 1 (Atxn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012726.2

ORF Insert Sequence:

ATGAAATCTA ACCAAGAGCG GAGCAATGAA TGCCTGCCTC CCAAGAAACG TGAGATCCCC 
GCCACCAGTC GGCCCTCCGA GGAGAAGGCC ACTGCTCTGC CCAGCGACAA CCACTGCGTG 
GAGGGTGTGG CATGGCTCCC CAGCACCCCT GGCAGCCGCG GCCACGGGGG TGGGCGGCAC 
GGGCCAGCAG GGACTTCCGG GGAACATGGT TTACAAGGAA TGGGTTTACA TAAAGCACTG 
TCCGCAGGGC TGGATTACTC CCCACCCAGT GCCCCCAGGT CGGTCCCCAC AGCCAACACG 
CTGCCCACCG TGTACCCTCC TCCTCAGTCA GGGACGCCGG TGTCTCCTGT GCAGTACGCC 
CACCTATCAC ATACCTTCCA GTTCATTGGG TCCTCCCAGT ATAGTGGGCC TTACGCGGGC 
TTTATCCCTT CCCAGCTGAT CTCCCCACCA GGCAACCCAG TCACCAGTGC GGTGGCCTCG 
GCTGCAGGGG CCACCACTCC ATCACAGCGC TCCCAGCTGG AGGCATATTC CACCCTGCTG 
GCCAACATGG GCAGTCTGAG CCAGGCACCA GGACACAAGG TTGAGCCCCC TCCGCAGCAG 
CACCTCGGCA GGGCTGCGGG ATTAGTCAAC CCGGGGTCCC CTCCACCTAC CCAGCAGAAC 
CAGTACATTC ACATTTCCAG CTCTCCGCAG AGCTCCGGGC GGGCAACATC TCCACCCATC 
CCGGTCCACC TCCATCCCCA TCAGACGATG ATCCCGCACA CGCTCACCCT GGGGCCTTCA 
TCCCAGGTGG TCGTGCAATA CAGTGACGCC GGAGGCCACT TTGTTCCTCG AGAGTCCACC 
AAAAAAGCAG AAAGCAGCAG GTTGCAGCAG GCTATGCAGG CCAAGGAGGT CCTCAATGGG 
GAGATGGAGA AAAGCCGGAG GTATGGGGCG TCATCTTCTG TGGAGCTGAG CCTGGGGAAG 
ACGAGCAGCA AGTCAGTGCC TCACCCCTAT GAGTCCAGGC ATGTGGTGGT CCACCCGAGC 
CCAGCAGACT ACAGCAGTCG TGATACCTCC GGGGTCCGTG GATCTGTGAT GGTCCTGCCC 
AACAGCAGCA CACCCTCAGC CGACCTGGAG ACACAGCAGG CCACACATCG AGAGGCCTCC 
CCATCCACCC TCAATGACAA GAGCGGTTTG CACCTAGGGA AGCCCGGCCA CAGGTCCTAC 
GCGCTGTCCC CGCACACGGT CATTCAGACC ACACACAGCG CATCAGAGCC TCTCCCGGTG 
GGCCTACCAG CCACGGCCTT CTATGCTGGC GCTCAACCTC CTGTCATCGG CTATCTGAGT 
AGCCAGCAGC AAGCAATCAC CTATGCTGGT GGTCTGCCCC AGCACCTGGT GATCCCAGGT 
ACCCAGCCCC TGCTCATCCC AGTGGGCAGC CCTGACATGG ACACACCTGG GGCAGCCTCG 
GCCATAGTGA CGTCATCGCC CCAGTTTGCT GCAGTACCTC ACACGTTTGT CACCACCGCC 
CTGCCCAAGA GCGAGAACTT CAACCCAGAG GCTCTGGTCA CCCAGGCAGC CTACCCAGCC 
ATGGTGCAGG CCCAGATCCA CCTGCCGGTG GTACAGTCCG TGGCATCCCC TGCCGCGGCA 
TCACCCACGC TGCCGCCATA TTTCATGAAA GGCTCCATCA TCCAGCTGGC CAACGGGGAG 
CTGAAGAAGG TAGAGGATCT GAAGACAGAG GATTTCATCC AGAGTGCAGA GATTAGCAAT 
GACCTCAAGA TCGACTCCAG TACTGTGGAG AGGATCGAGG ACAGCCACAG CCCCGGTGTG 
GCGGTGATAC AATTTGCTGT TGGTGAACAC CGAGCCCAGG TCAGTGTCGA AGTTTTGGTA 
GAGTATCCTT TTTTTGTATT TGGACAGGGC TGGTCATCCT GCTGTCCCGA GCGGACCAGC 
CAGCTCTTTG ATCTGCCGTG TTCCAAACTC TCCGTTGGGG ACGTCTGCAT CTCGCTCACC 
CTCAAGAACC TGAAGAATGG CTCTGTTAAA AAGGGCCAGC CCGTGGACCC TGCCAGTGCC 
CTGCTGAAGC ACGCAAAGAC CGACAGCCTG GCTGGCAGCA GACACAGATA CGCCGAGCAG 
GAAAACGGAA TCAACCAGGG GAGCGCCCAG GTGCTCTCTG AGAACGGCGA ACTGAAGTTT 
CCAGAAAAAA TTGGATTGCC TGCAGCACCC TTCCTCACCA AAATAGAACC GAGCAAGCCC 
ACAGCCACGA GGAAGAGGAG GTGGTCGGCG CCGGAGACCC GTAAACTGGA GAAGTCGGAG 
GACGAGCCAC CTTTGACTCT TCCCAAGCCT TCGCTCATTC CTCAGGAGGT TAAGATCTGC 
ATCGAAGGCC GATCTAACGT GGGCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.
Nature genetics49(4)527-536(2017 Apr)
Lu HC,Tan Q,Rousseaux MW,Wang W,Kim JY,Richman R,Wan YW,Yeh SY,Patel JM,Liu X,Lin T,Lee Y,Fryer JD,Han J,Chahrour M,Finnell RH,Lei Y,Zurita-Jimenez ME,Ahimaz P,Anyane-Yeboa K,Van Maldergem L,Lehalle D,Jean-Marcais N,Mosca-Boidron AL,Thevenon J,Cousin MA,Bro DE,Lanpher BC,Klee EW,Alexander N,Bainbridge MN,Orr HT,Sillitoe RV,Ljungberg MC,Liu Z,Schaaf CP,Zoghbi HY

ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Developmental cell21(4)746-57(2011 Oct)
Lee Y,Fryer JD,Kang H,Crespo-Barreto J,Bowman AB,Gao Y,Kahle JJ,Hong JS,Kheradmand F,Orr HT,Finegold MJ,Zoghbi HY

Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
PLoS genetics6(7)e1001021(2010 Jul)
Crespo-Barreto J,Fryer JD,Shaw CA,Orr HT,Zoghbi HY

Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
The EMBO journal29(14)2446-60(2010 Jul)
Shiwaku H,Yoshimura N,Tamura T,Sone M,Ogishima S,Watase K,Tagawa K,Okazawa H

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.
Human molecular genetics18(9)1556-65(2009 May)
Parfitt DA,Michael GJ,Vermeulen EG,Prodromou NV,Webb TR,Gallo JM,Cheetham ME,Nicoll WS,Blatch GL,Chapple JP

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Atxn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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