| Gene Symbol | CD38 |
| Entrez Gene ID | 12494 |
| Full Name | CD38 antigen |
| Synonyms | ADPRC 1,Cd38-rs1,I-19 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(House mouse) |
| Genome | |
| Summary | This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]. |
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CD38 cDNA ORF clone, Mus musculus(House mouse)
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Gene
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Clones
gRNAs
The following CD38 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD38 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu23369 
Clone ID Related Accession (Same CDS sequence) NM_007646.5 , NM_007646.4 Accession Version NM_007646.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 915bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1423843200000 Organism Mus musculus(House mouse) Product ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Comment
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGGCTAACT ATGAATTTAG CCAGGTGTCT GGGGACAGAC CTGGCTGCCG CCTCTCTAGG
AAAGCCCAGA TCGGTCTCGG AGTGGGTCTC CTGGTCCTGA TCGCCTTGGT AGTAGGGATC
GTGGTCATAC TTCTGAGGCC GCGCTCACTC CTGGTGTGGA CTGGAGAGCC TACCACGAAG
CACTTTTCTG ACATCTTCCT GGGACGCTGC CTCATCTACA CTCAGATCCT CCGGCCGGAG
ATGAGAGATC AGAACTGCCA GGAGATACTG AGTACATTCA AAGGAGCATT TGTTTCCAAG
AACCCTTGCA ACATCACAAG AGAAGACTAC GCCCCACTTG TTAAATTGGT CACTCAAACC
ATACCATGTA ACAAGACTCT CTTTTGGAGC AAATCCAAAC ACCTGGCCCA TCAATATACT
TGGATCCAGG GAAAGATGTT CACCCTGGAG GACACCCTGC TGGGCTACAT TGCTGATGAT
CTCAGGTGGT GTGGAGACCC TAGTACTTCT GATATGAACT ATGTCTCTTG CCCACATTGG
AGTGAAAACT GTCCCAACAA CCCTATTACT GTGTTCTGGA AAGTGATTTC CCAAAAGTTT
GCAGAAGATG CCTGTGGTGT GGTCCAAGTG ATGCTCAATG GGTCCCTCCG TGAGCCATTT
TACAAAAACA GCACCTTTGG AAGTGTGGAA GTCTTTAGTT TGGACCCAAA TAAGGTTCAT
AAACTACAGG CCTGGGTGAT GCACGACATC GAAGGAGCTT CCAGTAACGC ATGTTCAAGC
TCCTCCTTAA ATGAGCTGAA GATGATTGTG CAGAAAAGGA ATATGATATT TGCCTGCGTG
GATAACTACA GGCCTGCCAG GTTTCTTCAG TGTGTGAAGA ACCCTGAGCA CCCATCGTGT
AGACTTAATA CGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_031672.2 Translation 
Target ORF information:
RefSeq Version NM_007646.4 Organism Mus musculus(House mouse) Definition Mus musculus CD38 antigen (Cd38), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_007646.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGGCTAACT ATGAATTTAG CCAGGTGTCT GGGGACAGAC CTGGCTGCCG CCTCTCTAGG
AAAGCCCAGA TCGGTCTCGG AGTGGGTCTC CTGGTCCTGA TCGCCTTGGT AGTAGGGATC
GTGGTCATAC TTCTGAGGCC GCGCTCACTC CTGGTGTGGA CTGGAGAGCC TACCACGAAG
CACTTTTCTG ACATCTTCCT GGGACGCTGC CTCATCTACA CTCAGATCCT CCGGCCGGAG
ATGAGAGATC AGAACTGCCA GGAGATACTG AGTACATTCA AAGGAGCATT TGTTTCCAAG
AACCCTTGCA ACATCACAAG AGAAGACTAC GCCCCACTTG TTAAATTGGT CACTCAAACC
ATACCATGTA ACAAGACTCT CTTTTGGAGC AAATCCAAAC ACCTGGCCCA TCAATATACT
TGGATCCAGG GAAAGATGTT CACCCTGGAG GACACCCTGC TGGGCTACAT TGCTGATGAT
CTCAGGTGGT GTGGAGACCC TAGTACTTCT GATATGAACT ATGTCTCTTG CCCACATTGG
AGTGAAAACT GTCCCAACAA CCCTATTACT GTGTTCTGGA AAGTGATTTC CCAAAAGTTT
GCAGAAGATG CCTGTGGTGT GGTCCAAGTG ATGCTCAATG GGTCCCTCCG TGAGCCATTT
TACAAAAACA GCACCTTTGG AAGTGTGGAA GTCTTTAGTT TGGACCCAAA TAAGGTTCAT
AAACTACAGG CCTGGGTGAT GCACGACATC GAAGGAGCTT CCAGTAACGC ATGTTCAAGC
TCCTCCTTAA ATGAGCTGAA GATGATTGTG CAGAAAAGGA ATATGATATT TGCCTGCGTG
GATAACTACA GGCCTGCCAG GTTTCTTCAG TGTGTGAAGA ACCCTGAGCA CCCATCGTGT
AGACTTAATA CGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu23369 Clone ID Related Accession (Same CDS sequence) NM_007646.5 , NM_007646.4 Accession Version NM_007646.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 915bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577462400000 Organism Mus musculus(house mouse) Product ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK150412.1, BC046312.1 and AK038439.1. On Sep 10, 2015 this sequence version replaced NM_007646.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK038439.1, AK153215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGGCTAACT ATGAATTTAG CCAGGTGTCT GGGGACAGAC CTGGCTGCCG CCTCTCTAGG
AAAGCCCAGA TCGGTCTCGG AGTGGGTCTC CTGGTCCTGA TCGCCTTGGT AGTAGGGATC
GTGGTCATAC TTCTGAGGCC GCGCTCACTC CTGGTGTGGA CTGGAGAGCC TACCACGAAG
CACTTTTCTG ACATCTTCCT GGGACGCTGC CTCATCTACA CTCAGATCCT CCGGCCGGAG
ATGAGAGATC AGAACTGCCA GGAGATACTG AGTACATTCA AAGGAGCATT TGTTTCCAAG
AACCCTTGCA ACATCACAAG AGAAGACTAC GCCCCACTTG TTAAATTGGT CACTCAAACC
ATACCATGTA ACAAGACTCT CTTTTGGAGC AAATCCAAAC ACCTGGCCCA TCAATATACT
TGGATCCAGG GAAAGATGTT CACCCTGGAG GACACCCTGC TGGGCTACAT TGCTGATGAT
CTCAGGTGGT GTGGAGACCC TAGTACTTCT GATATGAACT ATGTCTCTTG CCCACATTGG
AGTGAAAACT GTCCCAACAA CCCTATTACT GTGTTCTGGA AAGTGATTTC CCAAAAGTTT
GCAGAAGATG CCTGTGGTGT GGTCCAAGTG ATGCTCAATG GGTCCCTCCG TGAGCCATTT
TACAAAAACA GCACCTTTGG AAGTGTGGAA GTCTTTAGTT TGGACCCAAA TAAGGTTCAT
AAACTACAGG CCTGGGTGAT GCACGACATC GAAGGAGCTT CCAGTAACGC ATGTTCAAGC
TCCTCCTTAA ATGAGCTGAA GATGATTGTG CAGAAAAGGA ATATGATATT TGCCTGCGTG
GATAACTACA GGCCTGCCAG GTTTCTTCAG TGTGTGAAGA ACCCTGAGCA CCCATCGTGT
AGACTTAATA CGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_031672.2 CDS 68..982 Translation
Target ORF information:
RefSeq Version NM_007646.5 Organism Mus musculus(house mouse) Definition Mus musculus CD38 antigen (Cd38), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_007646.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGGCTAACT ATGAATTTAG CCAGGTGTCT GGGGACAGAC CTGGCTGCCG CCTCTCTAGG
AAAGCCCAGA TCGGTCTCGG AGTGGGTCTC CTGGTCCTGA TCGCCTTGGT AGTAGGGATC
GTGGTCATAC TTCTGAGGCC GCGCTCACTC CTGGTGTGGA CTGGAGAGCC TACCACGAAG
CACTTTTCTG ACATCTTCCT GGGACGCTGC CTCATCTACA CTCAGATCCT CCGGCCGGAG
ATGAGAGATC AGAACTGCCA GGAGATACTG AGTACATTCA AAGGAGCATT TGTTTCCAAG
AACCCTTGCA ACATCACAAG AGAAGACTAC GCCCCACTTG TTAAATTGGT CACTCAAACC
ATACCATGTA ACAAGACTCT CTTTTGGAGC AAATCCAAAC ACCTGGCCCA TCAATATACT
TGGATCCAGG GAAAGATGTT CACCCTGGAG GACACCCTGC TGGGCTACAT TGCTGATGAT
CTCAGGTGGT GTGGAGACCC TAGTACTTCT GATATGAACT ATGTCTCTTG CCCACATTGG
AGTGAAAACT GTCCCAACAA CCCTATTACT GTGTTCTGGA AAGTGATTTC CCAAAAGTTT
GCAGAAGATG CCTGTGGTGT GGTCCAAGTG ATGCTCAATG GGTCCCTCCG TGAGCCATTT
TACAAAAACA GCACCTTTGG AAGTGTGGAA GTCTTTAGTT TGGACCCAAA TAAGGTTCAT
AAACTACAGG CCTGGGTGAT GCACGACATC GAAGGAGCTT CCAGTAACGC ATGTTCAAGC
TCCTCCTTAA ATGAGCTGAA GATGATTGTG CAGAAAAGGA ATATGATATT TGCCTGCGTG
GATAACTACA GGCCTGCCAG GTTTCTTCAG TGTGTGAAGA ACCCTGAGCA CCCATCGTGT
AGACTTAATA CGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
CD38 Deficiency Downregulates the Onset and Pathogenesis of Collagen-Induced Arthritis through the NF-
Journal of immunology research20197026067(2019)
Du Y,Dai Q,Zhang H,Li Q,Song K,Fu Y,Min W,Liu Z,Li R
Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries.
The American journal of pathology188(12)2948-2959(2018 12)
Yuan X,Bhat OM,Meng N,Lohner H,Li PL
Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities.
Structure (London, England : 1993)20(9)1585-95(2012 Sep)
Hara-Yokoyama M,Kukimoto-Niino M,Terasawa K,Harumiya S,Podyma-Inoue KA,Hino N,Sakamoto K,Itoh S,Hashii N,Hiruta Y,Kawasaki N,Mishima-Tsumagari C,Kaitsu Y,Matsumoto T,Wakiyama M,Shirouzu M,Kasama T,Takayanagi H,Utsunomiya-Tate N,Takatsu K,Katada T,Hirabayashi Y,Yokoyama S,Yanagishita M
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
The Biochemical journal362(Pt 1)125-30(2002 Feb)
Chini EN,Chini CC,Kato I,Takasawa S,Okamoto H
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo.
Nature medicine7(11)1209-16(2001 Nov)
Partida-Sánchez S,Cockayne DA,Monard S,Jacobson EL,Oppenheimer N,Garvy B,Kusser K,Goodrich S,Howard M,Harmsen A,Randall TD,Lund FE
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