| Gene Symbol | WFDC6 |
| Entrez Gene ID | 140870 |
| Full Name | WAP four-disulfide core domain 6 |
| Synonyms | C20orf171,HEL-S-295,WAP6,dJ461P17.11 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010]. |
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WFDC6 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following WFDC6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WFDC6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu29220 Clone ID Related Accession (Same CDS sequence) NM_080827.1 , NM_080827.2 Accession Version NM_080827.1 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 261bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1550160000000 Organism Homo sapiens(human) Product WAP four-disulfide core domain protein 6 precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF411861.1. ##Evidence-Data-START## Transcript exon combination :: AF411861.1, BC101604.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241ATGGGACTCT CAGGACTTCT GCCAATCCTG GTACCATTCA TCCTTTTGGG GGACATCCAG
GAACCTGGGC ACGCTGAAGG CATCCTTGGC AAGCCGTGTC CCAAAATCAA AGTGGAATGC
GAAGTGGAAG AAATAGACCA GTGTACCAAA CCCAGAGATT GCCCAGAAAA CATGAAGTGT
TGCCCGTTCA GCCGTGGAAA GAAATGTTTA GACTTCAGAA AGGTCAGCCT TACTTTATAC
CATAAGGAGG AGCTTGAATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_543017.1 CDS 89..349 Translation 
Target ORF information:
RefSeq Version NM_080827.1 Organism Homo sapiens(human) Definition Homo sapiens WAP four-disulfide core domain 6 (WFDC6), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_080827.1
ORF Insert Sequence:
1
61
121
181
241ATGGGACTCT CAGGACTTCT GCCAATCCTG GTACCATTCA TCCTTTTGGG GGACATCCAG
GAACCTGGGC ACGCTGAAGG CATCCTTGGC AAGCCGTGTC CCAAAATCAA AGTGGAATGC
GAAGTGGAAG AAATAGACCA GTGTACCAAA CCCAGAGATT GCCCAGAAAA CATGAAGTGT
TGCCCGTTCA GCCGTGGAAA GAAATGTTTA GACTTCAGAA AGGTCAGCCT TACTTTATAC
CATAAGGAGG AGCTTGAATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu29220 Clone ID Related Accession (Same CDS sequence) NM_080827.1 , NM_080827.2 Accession Version NM_080827.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 261bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1565193600000 Organism Homo sapiens(human) Product WAP four-disulfide core domain protein 6 precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF411861.1 and AL031663.2. On Jun 2, 2019 this sequence version replaced NM_080827.1. ##Evidence-Data-START## Transcript exon combination :: AF411861.1, GQ472217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241ATGGGACTCT CAGGACTTCT GCCAATCCTG GTACCATTCA TCCTTTTGGG GGACATCCAG
GAACCTGGGC ACGCTGAAGG CATCCTTGGC AAGCCGTGTC CCAAAATCAA AGTGGAATGC
GAAGTGGAAG AAATAGACCA GTGTACCAAA CCCAGAGATT GCCCAGAAAA CATGAAGTGT
TGCCCGTTCA GCCGTGGAAA GAAATGTTTA GACTTCAGAA AGGTCAGCCT TACTTTATAC
CATAAGGAGG AGCTTGAATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_543017.1 CDS 76..336 Translation
Target ORF information:
RefSeq Version NM_080827.2 Organism Homo sapiens(human) Definition Homo sapiens WAP four-disulfide core domain 6 (WFDC6), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_080827.2
ORF Insert Sequence:
1
61
121
181
241ATGGGACTCT CAGGACTTCT GCCAATCCTG GTACCATTCA TCCTTTTGGG GGACATCCAG
GAACCTGGGC ACGCTGAAGG CATCCTTGGC AAGCCGTGTC CCAAAATCAA AGTGGAATGC
GAAGTGGAAG AAATAGACCA GTGTACCAAA CCCAGAGATT GCCCAGAAAA CATGAAGTGT
TGCCCGTTCA GCCGTGGAAA GAAATGTTTA GACTTCAGAA AGGTCAGCCT TACTTTATAC
CATAAGGAGG AGCTTGAATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Reproduction and immunity-driven natural selection in the human WFDC locus.
Molecular biology and evolution30(4)938-50(2013 Apr)
Ferreira Z,Seixas S,Andrés AM,Kretzschmar WW,Mullikin JC,Cherukuri PF,Cruz P,Swanson WJ,,Clark AG,Green ED,Hurle B
The evolution of a genetic locus encoding small serine proteinase inhibitors.
Biochemical and biophysical research communications333(2)383-9(2005 Jul)
Clauss A,Lilja H,Lundwall A
A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.
The Biochemical journal368(Pt 1)233-42(2002 Nov)
Clauss A,Lilja H,Lundwall A
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