USP17L18 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	USP17L18
Entrez Gene ID	100287364
Full Name	ubiquitin specific peptidase 17-like family member 18
General protein information	Preferred Names ubiquitin specific peptidase 17-like family member 18 Names ubiquitin carboxyl-terminal hydrolase 17-like protein 18
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256859.1	NP_001243788.1	ubiquitin carboxyl-terminal hydrolase 17-like protein 18

Pathways from BioSystems

Homologies

Homo sapiens (human)	USP17L25	NP_001229255.1
Homo sapiens (human)	USP17L5	NP_001229258.1
Homo sapiens (human)	USP17L10	NP_001243781.1
Homo sapiens (human)	USP17L15	NP_001243823.1
Homo sapiens (human)	USP17L28	NP_001229260.1
Homo sapiens (human)	USP17L11	NP_001243783.1
Homo sapiens (human)	USP17L19	NP_001243789.1
Homo sapiens (human)	USP17L30	NP_001243796.1
Homo sapiens (human)	USP17L24	NP_001229256.1
Homo sapiens (human)	USP17L26	NP_001229257.1
Homo sapiens (human)	USP17L27	NP_001229259.1
Homo sapiens (human)	USP17L18	NP_001243788.1
Homo sapiens (human)	USP17L20	NP_001243790.1
Homo sapiens (human)	USP17L21	NP_001243791.1
Homo sapiens (human)	USP17L22	NP_001243792.1
Homo sapiens (human)	USP17L13	NP_001243784.1
Homo sapiens (human)	USP17L17	NP_001243786.1
Homo sapiens (human)	USP17L29	NP_001229261.1
Homo sapiens (human)	USP17L12	NP_001243782.1

Gene Ontology
Bibliography

Related articles in PubMed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.
Ramakrishna S, Suresh B, Lee EJ, Lee HJ, Ahn WS, Baek KH
The Journal of biological chemistry286(12)10505-14(2011 Mar)

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
de la Vega M, Kelvin AA, Dunican DJ, McFarlane C, Burrows JF, Jaworski J, Stevenson NJ, Dib K, Rappoport JZ, Scott CJ, Long A, Johnston JA
Nature communications2259(2011 Mar)

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.
Ramakrishna S, Suresh B, Kang IC, Baek KH
Hybridoma (2005)29(4)311-9(2010 Aug)

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.
McFarlane C, Kelvin AA, de la Vega M, Govender U, Scott CJ, Burrows JF, Johnston JA
Cancer research70(8)3329-39(2010 Apr)

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.
Burrows JF, Scott CJ, Johnston JA
BMC genomics11250(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following USP17L18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the USP17L18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu01276	NM_001256859.1 Latest version!	Homo sapiens ubiquitin specific peptidase 17 like family member 18 (USP17L18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

USP17L18 ( NM_001256859.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243788.1 Homo sapiens ubiquitin specific peptidase 17 like family member 18 (USP17L18), mRNA.

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CloneID	OHu01276
Clone ID Related Accession (Same CDS sequence)	NM_001256859.1
Accession Version	NM_001256859.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1593bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1561737600000
Organism	Homo sapiens(human)
Product	ubiquitin carboxyl-terminal hydrolase 17-like protein 18
Comment	Comment: INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from AC108519.4. On Mar 3, 2012 this sequence version replaced XM_002342435.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000504209.1/ ENSP00000423503.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGGACG ACTCACTCTA CTTGGGAGGT GAGTGGCAGT TCAACCACTT TTCAAAACTC 
ACATCTTCTC GGCCCGATGC AGCTTTTGCT GAAATCCAGC GGACTTCTCT CCCTGAGAAG 
TCACCACTCT CATGTGAGAC CCGTGTCGAC CTCTGTGATG ATTTGGCTCC TGTGGCAAGA 
CAGCTTGCTC CCAGGGAGAA GCTTCCTCTG AGTAGCAGGA GACCTGCTGC GGTGGGGGCT 
GGGCTCCAGA ATATGGGAAA TACCTGCTAC GTGAACGCTT CCTTGCAGTG CCTGACATAC 
ACACCGCCCC TTGCCAACTA CATGCTGTCC CGGGAGCACT CTCAAACGTG TCATCGTCAC 
AAGGGCTGTA TGCTCTGTAC GATGCAAGCT CACATCACAC GGGCCCTCCA CAATCCTGGC 
CACGTCATCC AGCCCTCACA GGCATTGGCT GCTGGCTTCC ATAGAGGCAA GCAGGAAGAT 
GCCCATGAAT TTCTCATGTT CACTGTGGAT GCCATGAAAA AGGCATGCCT TCCCGGGCAC 
AAGCAGGTGG ATCATCACTC TAAGGACACC ACCCTCATCC ACCAAATATT TGGAGGCTAC 
TGGAGATCTC AAATCAAGTG TCTCCACTGC CACGGCATTT CAGACACTTT TGACCCTTAC 
CTGGACATCG CCCTGGATAT CCAGGCAGCT CAGAGTGTCC AGCAAGCTTT GGAACAGTTG 
GTGAAGCCCG AAGAACTCAA TGGAGAGAAT GCCTATCATT GTGGTGTTTG TCTCCAGAGG 
GCGCCGGCCT CCAAGACGTT AACTTTACAC ACCTCTGCCA AGGTCCTCAT CCTTGTATTG 
AAGAGATTCT CCGATGTCAC AGGCAACAAG ATTGCCAAGA ATGTGCAATA TCCTGAGTGC 
CTTGACATGC AGCCATACAT GTCTCAGACG AACACAGGAC CTCTCGTCTA TGTCCTCTAT 
GCTGTGCTGG TCCACGCTGG GTGGAGTTGT CACAACGGAC ATTACTTCTC TTATGTCAAA 
GCTCAAGAAG GCCAGTGGTA TAAAATGGAT GATGCCGAGG TCACCGCCTC TAGCATCACT 
TCTGTCCTGA GTCAACAGGC CTACGTCCTC TTTTACATCC AGAAGAGTGA ATGGGAAAGA 
CACAGTGAGA GTGTGTCAAG AGGCAGGGAA CCAAGAGCCC TTGGCGCAGA AGACACAGAC 
AGGCGAGCAA AGCAAGGAGA GCTCAAGAGA GACCACCCCT GCCTCCAGGC CCCCGAGTTG 
GACGAGCACT TGGTGGAAAG AGCCACTCAG GAAAGCACCT TAGACCACTG GAAATTCCTT 
CAAGAGCAAA ACAAAACGAA GCCTGAGTTC AACGTCAGAA AAGTCGAAGG TACCCTGCCT 
CCCGACGTAC TTGTGATTCA TCAATCAAAA TACAAGTGTG GGATGAAGAA CCATCATCCT 
GAACAGCAAA GCTCCCTGCT AAACCTCTCT TCGACGACCC CGACACATCA GGAGTCCATG 
AACACTGGCA CACTCGCTTC CCTGCGAGGG AGGGCCAGGA GATCCAAAGG GAAGAACAAA 
CACAGCAAGA GGGCTCTGCT TGTGTGCCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243788.1
CDS	1..1593
Translation	MEDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGNKIAKNVQYPECLDMQPYMSQTNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRAKQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLSSTTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ

Target ORF information:

RefSeq Version	NM_001256859.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin specific peptidase 17 like family member 18 (USP17L18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256859.1

ORF Insert Sequence:

ATGGAGGACG ACTCACTCTA CTTGGGAGGT GAGTGGCAGT TCAACCACTT TTCAAAACTC 
ACATCTTCTC GGCCCGATGC AGCTTTTGCT GAAATCCAGC GGACTTCTCT CCCTGAGAAG 
TCACCACTCT CATGTGAGAC CCGTGTCGAC CTCTGTGATG ATTTGGCTCC TGTGGCAAGA 
CAGCTTGCTC CCAGGGAGAA GCTTCCTCTG AGTAGCAGGA GACCTGCTGC GGTGGGGGCT 
GGGCTCCAGA ATATGGGAAA TACCTGCTAC GTGAACGCTT CCTTGCAGTG CCTGACATAC 
ACACCGCCCC TTGCCAACTA CATGCTGTCC CGGGAGCACT CTCAAACGTG TCATCGTCAC 
AAGGGCTGTA TGCTCTGTAC GATGCAAGCT CACATCACAC GGGCCCTCCA CAATCCTGGC 
CACGTCATCC AGCCCTCACA GGCATTGGCT GCTGGCTTCC ATAGAGGCAA GCAGGAAGAT 
GCCCATGAAT TTCTCATGTT CACTGTGGAT GCCATGAAAA AGGCATGCCT TCCCGGGCAC 
AAGCAGGTGG ATCATCACTC TAAGGACACC ACCCTCATCC ACCAAATATT TGGAGGCTAC 
TGGAGATCTC AAATCAAGTG TCTCCACTGC CACGGCATTT CAGACACTTT TGACCCTTAC 
CTGGACATCG CCCTGGATAT CCAGGCAGCT CAGAGTGTCC AGCAAGCTTT GGAACAGTTG 
GTGAAGCCCG AAGAACTCAA TGGAGAGAAT GCCTATCATT GTGGTGTTTG TCTCCAGAGG 
GCGCCGGCCT CCAAGACGTT AACTTTACAC ACCTCTGCCA AGGTCCTCAT CCTTGTATTG 
AAGAGATTCT CCGATGTCAC AGGCAACAAG ATTGCCAAGA ATGTGCAATA TCCTGAGTGC 
CTTGACATGC AGCCATACAT GTCTCAGACG AACACAGGAC CTCTCGTCTA TGTCCTCTAT 
GCTGTGCTGG TCCACGCTGG GTGGAGTTGT CACAACGGAC ATTACTTCTC TTATGTCAAA 
GCTCAAGAAG GCCAGTGGTA TAAAATGGAT GATGCCGAGG TCACCGCCTC TAGCATCACT 
TCTGTCCTGA GTCAACAGGC CTACGTCCTC TTTTACATCC AGAAGAGTGA ATGGGAAAGA 
CACAGTGAGA GTGTGTCAAG AGGCAGGGAA CCAAGAGCCC TTGGCGCAGA AGACACAGAC 
AGGCGAGCAA AGCAAGGAGA GCTCAAGAGA GACCACCCCT GCCTCCAGGC CCCCGAGTTG 
GACGAGCACT TGGTGGAAAG AGCCACTCAG GAAAGCACCT TAGACCACTG GAAATTCCTT 
CAAGAGCAAA ACAAAACGAA GCCTGAGTTC AACGTCAGAA AAGTCGAAGG TACCCTGCCT 
CCCGACGTAC TTGTGATTCA TCAATCAAAA TACAAGTGTG GGATGAAGAA CCATCATCCT 
GAACAGCAAA GCTCCCTGCT AAACCTCTCT TCGACGACCC CGACACATCA GGAGTCCATG 
AACACTGGCA CACTCGCTTC CCTGCGAGGG AGGGCCAGGA GATCCAAAGG GAAGAACAAA 
CACAGCAAGA GGGCTCTGCT TGTGTGCCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.
The Journal of biological chemistry286(12)10505-14(2011 Mar)
Ramakrishna S,Suresh B,Lee EJ,Lee HJ,Ahn WS,Baek KH

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
Nature communications2259(2011 Mar)
de la Vega M,Kelvin AA,Dunican DJ,McFarlane C,Burrows JF,Jaworski J,Stevenson NJ,Dib K,Rappoport JZ,Scott CJ,Long A,Johnston JA

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.
Hybridoma (2005)29(4)311-9(2010 Aug)
Ramakrishna S,Suresh B,Kang IC,Baek KH

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.
Cancer research70(8)3329-39(2010 Apr)
McFarlane C,Kelvin AA,de la Vega M,Govender U,Scott CJ,Burrows JF,Johnston JA

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.
BMC genomics11250(2010 Apr)
Burrows JF,Scott CJ,Johnston JA