sesn3 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	sesn3
Entrez Gene ID	406840
Full Name	sestrin 3
Synonyms	cb261,sb:cb261,wu:fb77c04,wu:fc41d03,wu:fd59d12,zgc:56722
General protein information	Preferred Names sestrin 3 Names sestrin-3
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_213519.2	NP_998684.2	sestrin-3

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	SESN3	XP_001091126.1
Rattus norvegicus (Norway rat)	Sesn3	NP_001101595.1
Danio rerio (zebrafish)	sesn3	NP_998684.1
Drosophila melanogaster (fruit fly)	Sesn	NP_001097438.1
Pan troglodytes (chimpanzee)	SESN3	XP_003313313.1
Canis lupus familiaris (dog)	SESN3	XP_542236.1
Bos taurus (cattle)	SESN3	XP_002693003.3
Gallus gallus (chicken)	SESN3	XP_004938903.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007169	XP_001688028.1
Caenorhabditis elegans (roundworm)	sesn-1	NP_490664.2
Homo sapiens (human)	SESN3	NP_653266.2
Mus musculus (house mouse)	Sesn3	NP_084537.2
Xenopus tropicalis (tropical clawed frog)	sesn3	NP_001184122.1

Gene Ontology
Bibliography

Related articles in PubMed

Tris(1,3-dichloro-2-propyl) Phosphate Exposure During the Early-Blastula Stage Alters the Normal Trajectory of Zebrafish Embryogenesis.
Dasgupta S, Cheng V, Vliet SMF, Mitchell CA, Volz DC
Environmental science & technology52(18)10820-10828(2018 09)

Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways.
Sánchez E, Azcona LJ, Paisán-Ruiz C
Molecular neurobiology55(8)6734-6754(2018 Aug)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O'Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffey AJ, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ, Petretto E
Nature communications66031(2015 Jan)

Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1.
Todd PK, Ackall FY, Hur J, Sharma K, Paulson HL, Dowling JJ
Disease models & mechanisms7(1)143-55(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following sesn3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the sesn3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa53201	NM_213519.2 Latest version!	Danio rerio sestrin 3 (sesn3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

sesn3 ( NM_213519.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_998684.2 Danio rerio sestrin 3 (sesn3), mRNA.

Price & Availability↑

CloneID	ODa53201
Clone ID Related Accession (Same CDS sequence)	NM_213519.2
Accession Version	NM_213519.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1401bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1549641600000
Organism	Danio rerio(zebrafish)
Product	sestrin-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR387932.20, AW128658.1, AW059325.1, AW128415.1 and AW019446.1. On Sep 4, 2015 this sequence version replaced NM_213519.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC045518.1, GDQH01001165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACGGAA CCGCAGGCAT CTGTAACCAC TGCCGAAACA CGATCAGAGA GAAGGAAAAA 
ATGTCAAGAC ACATATCAAC AGGACCAAGC TCATTTATTC CAGAAAACGA GATCATAGGA 
GCAATGCCTT TGAGTGATTC CACAGTGATG CTCTTGGATG AAGAGTTCAG CGGCCGCATG 
GACAACCTGA CACAAGTGAT GGGCCTCCAT CCGCATTACC TGCAAGCCTT CCTGCGCTGC 
CACTATTACC TCTTGAGGAT GGACGGCCCT CTTCCACTCC ACTACAGGCA TTATATCGCA 
ATAATGGCTG CAGCAAGGCA TCAGTGCTCC ACGCTAGTAT GTCACCATGT GCAAGAGTTT 
GAGCAGATTG GAGTCTGTTC TGATTGGCTG AGAGGTCTGG AGTTCTGCCC GCAACGGCTT 
CGCAACCTCA ACGAGATTAA TAAGATCCTC GCGCACAGAC CCTGGCTCAT CACCAAGCAA 
CATATACAAG CTCTTGTGAA GACTGGAGAA CACAGCTGGT CTCTGGCAGA GCTGGTTCAC 
GCGGTCGTAC TGTTGGCTCA CTTCCACGCC CTGGCTAGTT TTGTGTTTGG CAGCGGTGTC 
AACCCTGACC CTGAGGTCAC AGAAGTCAAC GGGGTCACAG GTGACCTTTG CCCTCCAGTC 
ATGAAGGGTT TATGCACCTG CCACCTAACA AACAGCAACC AAGCCAACGG GAACCCGAAC 
ACTGGGAGTG AGTTGGAAGC TCTGATGGAG CGAATGAAGC GACTGCTGGA GGAGAGAGAG 
GATGATGATG CGTCAGAGGA GGAGATGTTC ACTCGCTTCG AGAAAGAGAA GAAAGAGAGT 
CTCCTGGTGG TGTCTGCAGG GTTTGATGAG GAAGTGGTTC CTCCTTCGCC CGTGGCTCGG 
TTTGTAGACG ACCCATCGTT TGGATATCAA GATTTTGCAC GACACGGAGA AGACAATCCA 
CCGACATTTA AAGCACAAGA CTACTCGTGG GAGGATCACG GTTTCTCTTT GGTTAACCGG 
TTGTACTCTG ACATCGGGCA CCTGCTGGAT GATAAGTTCA GAACGGCCTG TGATTTGACG 
TATTATAACA TGGCCAGTCA TGAGGGTGTG GATACTAGTA TGCTGCGTAG GGCTCTCTTC 
AACTATGTCC ACTGCATGTA CGGGATACGA TATGACGATT ATGACTACGG TGAGGTGAAT 
CAGCTGTTGG AGCGCAGCCT GAAGGTTTAC ATTAAAACAG TGACGTGTTA TCCAGAGAGA 
ACCACCTGCC GCATGTATGA GAGCTACTGG CACCAGTTTA GACACTCCGA GAAGGTCCAT 
GTGAATTTGC TTCTAATGGA GGCCCGAATG CAGGCAGAGC TGCTCTATGC TTTGAGGGCC 
ATCACTCATT ATATGACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_998684.2
CDS	148..1548
Translation	MNGTAGICNHCRNTIREKEKMSRHISTGPSSFIPENEIIGAMPLSDSTVMLLDEEFSGRMDNLTQVMGLHPHYLQAFLRCHYYLLRMDGPLPLHYRHYIAIMAAARHQCSTLVCHHVQEFEQIGVCSDWLRGLEFCPQRLRNLNEINKILAHRPWLITKQHIQALVKTGEHSWSLAELVHAVVLLAHFHALASFVFGSGVNPDPEVTEVNGVTGDLCPPVMKGLCTCHLTNSNQANGNPNTGSELEALMERMKRLLEEREDDDASEEEMFTRFEKEKKESLLVVSAGFDEEVVPPSPVARFVDDPSFGYQDFARHGEDNPPTFKAQDYSWEDHGFSLVNRLYSDIGHLLDDKFRTACDLTYYNMASHEGVDTSMLRRALFNYVHCMYGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTCRMYESYWHQFRHSEKVHVNLLLMEARMQAELLYALRAITHYMT

Target ORF information:

RefSeq Version	NM_213519.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio sestrin 3 (sesn3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_213519.2

ORF Insert Sequence:

ATGAACGGAA CCGCAGGCAT CTGTAACCAC TGCCGAAACA CGATCAGAGA GAAGGAAAAA 
ATGTCAAGAC ACATATCAAC AGGACCAAGC TCATTTATTC CAGAAAACGA GATCATAGGA 
GCAATGCCTT TGAGTGATTC CACAGTGATG CTCTTGGATG AAGAGTTCAG CGGCCGCATG 
GACAACCTGA CACAAGTGAT GGGCCTCCAT CCGCATTACC TGCAAGCCTT CCTGCGCTGC 
CACTATTACC TCTTGAGGAT GGACGGCCCT CTTCCACTCC ACTACAGGCA TTATATCGCA 
ATAATGGCTG CAGCAAGGCA TCAGTGCTCC ACGCTAGTAT GTCACCATGT GCAAGAGTTT 
GAGCAGATTG GAGTCTGTTC TGATTGGCTG AGAGGTCTGG AGTTCTGCCC GCAACGGCTT 
CGCAACCTCA ACGAGATTAA TAAGATCCTC GCGCACAGAC CCTGGCTCAT CACCAAGCAA 
CATATACAAG CTCTTGTGAA GACTGGAGAA CACAGCTGGT CTCTGGCAGA GCTGGTTCAC 
GCGGTCGTAC TGTTGGCTCA CTTCCACGCC CTGGCTAGTT TTGTGTTTGG CAGCGGTGTC 
AACCCTGACC CTGAGGTCAC AGAAGTCAAC GGGGTCACAG GTGACCTTTG CCCTCCAGTC 
ATGAAGGGTT TATGCACCTG CCACCTAACA AACAGCAACC AAGCCAACGG GAACCCGAAC 
ACTGGGAGTG AGTTGGAAGC TCTGATGGAG CGAATGAAGC GACTGCTGGA GGAGAGAGAG 
GATGATGATG CGTCAGAGGA GGAGATGTTC ACTCGCTTCG AGAAAGAGAA GAAAGAGAGT 
CTCCTGGTGG TGTCTGCAGG GTTTGATGAG GAAGTGGTTC CTCCTTCGCC CGTGGCTCGG 
TTTGTAGACG ACCCATCGTT TGGATATCAA GATTTTGCAC GACACGGAGA AGACAATCCA 
CCGACATTTA AAGCACAAGA CTACTCGTGG GAGGATCACG GTTTCTCTTT GGTTAACCGG 
TTGTACTCTG ACATCGGGCA CCTGCTGGAT GATAAGTTCA GAACGGCCTG TGATTTGACG 
TATTATAACA TGGCCAGTCA TGAGGGTGTG GATACTAGTA TGCTGCGTAG GGCTCTCTTC 
AACTATGTCC ACTGCATGTA CGGGATACGA TATGACGATT ATGACTACGG TGAGGTGAAT 
CAGCTGTTGG AGCGCAGCCT GAAGGTTTAC ATTAAAACAG TGACGTGTTA TCCAGAGAGA 
ACCACCTGCC GCATGTATGA GAGCTACTGG CACCAGTTTA GACACTCCGA GAAGGTCCAT 
GTGAATTTGC TTCTAATGGA GGCCCGAATG CAGGCAGAGC TGCTCTATGC TTTGAGGGCC 
ATCACTCATT ATATGACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tris(1,3-dichloro-2-propyl) Phosphate Exposure During the Early-Blastula Stage Alters the Normal Trajectory of Zebrafish Embryogenesis.
Environmental science & technology52(18)10820-10828(2018 09)
Dasgupta S,Cheng V,Vliet SMF,Mitchell CA,Volz DC

Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways.
Molecular neurobiology55(8)6734-6754(2018 Aug)
Sánchez E,Azcona LJ,Paisán-Ruiz C

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Nature communications66031(2015 Jan)
Johnson MR,Behmoaras J,Bottolo L,Krishnan ML,Pernhorst K,Santoscoy PLM,Rossetti T,Speed D,Srivastava PK,Chadeau-Hyam M,Hajji N,Dabrowska A,Rotival M,Razzaghi B,Kovac S,Wanisch K,Grillo FW,Slaviero A,Langley SR,Shkura K,Roncon P,De T,Mattheisen M,Niehusmann P,O'Brien TJ,Petrovski S,von Lehe M,Hoffmann P,Eriksson J,Coffey AJ,Cichon S,Walker M,Simonato M,Danis B,Mazzuferi M,Foerch P,Schoch S,De Paola V,Kaminski RM,Cunliffe VT,Becker AJ,Petretto E

Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1.
Disease models & mechanisms7(1)143-55(2014 Jan)
Todd PK,Ackall FY,Hur J,Sharma K,Paulson HL,Dowling JJ

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sesn3 cDNA ORF clone, Danio rerio(zebrafish)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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